A Novel Circular Delta‐XBB.1.5 RBD Dimeric Protein Subunit Vaccine Mediated by Split Intein Elicits an Immune Response and Protection Against Multiple SARS‐CoV‐2 Variants in Mice

ABSTRACT SARS‐CoV‐2 continues to mutate, leading to breakthrough infections. The development of new vaccine strategies to combat various strains is crucial. Protein cyclization can enhance thermal stability and may improve immunogenicity. Here, we designed a cyclic tandem dimeric receptor‐binding do...

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Veröffentlicht in:	Journal of medical virology 2024-12, Vol.96 (12), p.e70134-n/a
Hauptverfasser:	Li, Kangyin, Wu, Yan, Zhang, Hongqing, Chen, Shaohong, Wu, Bihao, Li, Tingting, Li, Entao, Luo, Feiyang, Jin, Aishun, Zhang, Bo, Zhang, Yanan, Gong, Rui, Zhang, Huajun, Chiu, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology circular protein COVID-19 COVID-19 - immunology COVID-19 - prevention & control COVID-19 Vaccines - immunology Dimers Epitopes Female Humans Immune response Immune response (cell-mediated) Immune system Immunity, Cellular Immunization Immunogenicity intein Inteins Mice Mice, Inbred BALB C Neutralizing Proteins RBD SARS-CoV-2 - genetics SARS-CoV-2 - immunology SARS‐CoV‐2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology subunit protein vaccine Thermal stability Vaccines Vaccines, Subunit - administration & dosage Vaccines, Subunit - genetics Vaccines, Subunit - immunology
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