Age differences in organophosphorus nerve agent-induced seizure, blood brain barrier integrity, and neurodegeneration in midazolam-treated rats

Exposure to organophosphorus nerve agents irreversibly inhibits acetylcholinesterase and may lead to cholinergic crisis and seizures. Although benzodiazepines are the standard of care after nerve agent-induced status epilepticus, when treatment is delayed for up to 30 min or more, refractory status...

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Veröffentlicht in:	Experimental neurology 2025-03, Vol.385, p.115122, Article 115122
Hauptverfasser:	Nguyen, Donna A., Niquet, Jerome, Marrero-Rosado, Brenda, Schultz, Caroline R., Stone, Michael F., de Araujo Furtado, Marcio, Biney, Abiel K., Lumley, Lucille A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Benzodiazepines Blood brain barrier Developmental toxicity Midazolam Neurodegeneration Organophosphorus nerve agent Refractory status epilepticus Sex Soman
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