Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites

Neuronal dendrites must relay synaptic inputs over long distances, but the mechanisms by which activity-evoked intracellular signals propagate over macroscopic distances remain unclear. Here, we discovered a system of periodically arranged endoplasmic reticulum-plasma membrane (ER-PM) junctions tili...

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Veröffentlicht in:	Cell 2024-12
Hauptverfasser:	Benedetti, Lorena, Fan, Ruolin, Weigel, Aubrey V., Moore, Andrew S., Houlihan, Patrick R., Kittisopikul, Mark, Park, Grace, Petruncio, Alyson, Hubbard, Philip M., Pang, Song, Xu, C. Shan, Hess, Harald F., Saalfeld, Stephan, Rangaraju, Vidhya, Clapham, David E., De Camilli, Pietro, Ryan, Timothy A., Lippincott-Schwartz, Jennifer
Format:	Artikel
Sprache:	eng
Schlagworte:	Ca2+/calmodulin-dependent protein kinase II CaMKII Drosophila melanogaster endoplasmic reticulum ER-PM junctions hippocampal neurons Junctophilin ryanodine receptors RyRs VGCC voltage-gated calcium channels volume electron microscopy
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