Multi-omics approaches reveal that diffuse midline gliomas present altered DNA replication and are susceptible to replication stress therapy

The fatal diffuse midline gliomas (DMG) are characterized by an undruggable H3K27M mutation in H3.1 or H3.3. K27M impairs normal development by stalling differentiation. The identification of targetable pathways remains very poorly explored. Toward this goal, we undertake a multi-omics approach to e...

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Veröffentlicht in:	Genome Biology (Online Edition) 2024-12, Vol.25 (1), p.319-19
Hauptverfasser:	Hains, Anastasia E, Chetal, Kashish, Nakatani, Tsunetoshi, Marques, Joana G, Ettinger, Andreas, Junior, Carlos A O Biagi, Gonzalez-Sandoval, Adriana, Pillai, Renjitha, Filbin, Mariella G, Torres-Padilla, Maria-Elena, Sadreyev, Ruslan I, Van Rechem, Capucine
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Anopheles Brain Neoplasms - genetics Brain Neoplasms - pathology Cancer Cell cycle Cell Cycle - genetics Cell Line, Tumor Diffuse midline gliomas H3 K27-altered DNA DNA Replication Gene expression Gene Expression Regulation, Neoplastic Genes Genetic aspects Genomes Genomics Glioma - genetics Glioma - pathology Gliomas H3K27M Histones - metabolism Humans Multiomics Mutation Replication stress Replication timing Transcriptome
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