The increase in the expression of circRNAs may contributes to a poor prognosis in acute myeloid leukemia: A systematic review and meta-analysis
The primary methods for defining the prognostic risk of AML patients are cytogenetic and molecular analysis at the time of diagnosis. However, the prognosis of intermediate-risk patients is still not well assessed for biomarkers. The main objective of this meta-analysis is to evaluate the relationsh...
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| Veröffentlicht in: | Leukemia research 2025-01, Vol.148, p.107639, Article 107639 |
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| creator | Li, Meng Zhang, Shiming Wei, Junfan Liu, Mengfei Zhang, Bohao Li, Shen Xiao, Yue Yu, Yuandong Song, Ruipeng |
| description | The primary methods for defining the prognostic risk of AML patients are cytogenetic and molecular analysis at the time of diagnosis. However, the prognosis of intermediate-risk patients is still not well assessed for biomarkers. The main objective of this meta-analysis is to evaluate the relationship between circRNAs and AML prognosis, to provide a theoretical basis for finding effective prognostic indicators in intermediate-risk patients, and to provide an important scientific basis for the development or revision of WHO practice guidelines and ELN risk classification, and to highlight the importance of continuing to focus on and evaluate the prognostic impact of circRNAs on AML in future studies.
We performed a comprehensive literature search across PubMed, the Cochrane Library, and Web of Science databases for studies published up to September 15, 2024. Articles were selected based on inclusion criteria. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of studies. The outcome measure of overall survival (OS) was used, and hazard ratios (HR) and 95 % confidence intervals (CI) were pooled to estimate the relationship between circRNA expression and prognosis in AML using STATA 17.0 software.
A total of 13 studies involving 1401 AML patients were included. The studies showed a significantly increased hazard ratio (HR) of upregulated CircRNA expression for OS (HR=1.87, 95 % CI=1.51–2.32, P |
| doi_str_mv | 10.1016/j.leukres.2024.107639 |
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We performed a comprehensive literature search across PubMed, the Cochrane Library, and Web of Science databases for studies published up to September 15, 2024. Articles were selected based on inclusion criteria. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of studies. The outcome measure of overall survival (OS) was used, and hazard ratios (HR) and 95 % confidence intervals (CI) were pooled to estimate the relationship between circRNA expression and prognosis in AML using STATA 17.0 software.
A total of 13 studies involving 1401 AML patients were included. The studies showed a significantly increased hazard ratio (HR) of upregulated CircRNA expression for OS (HR=1.87, 95 % CI=1.51–2.32, P < 0.001). The results of subgroups analysis showed a significant increase in the hazard ratio (HR) for upregulation of CircRNA expression in EFS and circ_0012152（HR= 1.66, 95 % CI= 1.19–2.32, P < 0.005 and HR= 2.26,95 % CI= 1.27–4.00, P < 0.005), respectively. No significant heterogeneity or publication bias was detected.
Upregulated circRNA expression is significantly associated with poor prognosis in AML patients and may serve as a prognostic marker for AML.
•This study evaluated the relationship between circRNAs and AML prognosis.•Provide evidence for finding new prognostic indicators for intermediate-risk patients.•To provide a scientific basis for the development and revision of AML classification guidelines by the World Health Organization and the European Leukemia Network.•This study demonstrates that circRNAs expressed up-regulated in AML are associated with poor prognosis in AML patients.</description><identifier>ISSN: 0145-2126</identifier><identifier>ISSN: 1873-5835</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/j.leukres.2024.107639</identifier><identifier>PMID: 39708434</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acute myeloid leukemia ; Biomarkers, Tumor - genetics ; CircRNA ; Humans ; Leukemia, Myeloid, Acute - diagnosis ; Leukemia, Myeloid, Acute - genetics ; Leukemia, Myeloid, Acute - mortality ; Leukemia, Myeloid, Acute - pathology ; Meta-analysis ; Prognosis ; RNA, Circular - genetics</subject><ispartof>Leukemia research, 2025-01, Vol.148, p.107639, Article 107639</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1941-185d396f15410395ecf7cf4859462d6484e76f3eb1097e20cb8aba75335df0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0145212624002054$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39708434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Meng</creatorcontrib><creatorcontrib>Zhang, Shiming</creatorcontrib><creatorcontrib>Wei, Junfan</creatorcontrib><creatorcontrib>Liu, Mengfei</creatorcontrib><creatorcontrib>Zhang, Bohao</creatorcontrib><creatorcontrib>Li, Shen</creatorcontrib><creatorcontrib>Xiao, Yue</creatorcontrib><creatorcontrib>Yu, Yuandong</creatorcontrib><creatorcontrib>Song, Ruipeng</creatorcontrib><title>The increase in the expression of circRNAs may contributes to a poor prognosis in acute myeloid leukemia: A systematic review and meta-analysis</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>The primary methods for defining the prognostic risk of AML patients are cytogenetic and molecular analysis at the time of diagnosis. However, the prognosis of intermediate-risk patients is still not well assessed for biomarkers. The main objective of this meta-analysis is to evaluate the relationship between circRNAs and AML prognosis, to provide a theoretical basis for finding effective prognostic indicators in intermediate-risk patients, and to provide an important scientific basis for the development or revision of WHO practice guidelines and ELN risk classification, and to highlight the importance of continuing to focus on and evaluate the prognostic impact of circRNAs on AML in future studies.
We performed a comprehensive literature search across PubMed, the Cochrane Library, and Web of Science databases for studies published up to September 15, 2024. Articles were selected based on inclusion criteria. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of studies. The outcome measure of overall survival (OS) was used, and hazard ratios (HR) and 95 % confidence intervals (CI) were pooled to estimate the relationship between circRNA expression and prognosis in AML using STATA 17.0 software.
A total of 13 studies involving 1401 AML patients were included. The studies showed a significantly increased hazard ratio (HR) of upregulated CircRNA expression for OS (HR=1.87, 95 % CI=1.51–2.32, P < 0.001). The results of subgroups analysis showed a significant increase in the hazard ratio (HR) for upregulation of CircRNA expression in EFS and circ_0012152（HR= 1.66, 95 % CI= 1.19–2.32, P < 0.005 and HR= 2.26,95 % CI= 1.27–4.00, P < 0.005), respectively. No significant heterogeneity or publication bias was detected.
Upregulated circRNA expression is significantly associated with poor prognosis in AML patients and may serve as a prognostic marker for AML.
•This study evaluated the relationship between circRNAs and AML prognosis.•Provide evidence for finding new prognostic indicators for intermediate-risk patients.•To provide a scientific basis for the development and revision of AML classification guidelines by the World Health Organization and the European Leukemia Network.•This study demonstrates that circRNAs expressed up-regulated in AML are associated with poor prognosis in AML patients.</description><subject>Acute myeloid leukemia</subject><subject>Biomarkers, Tumor - genetics</subject><subject>CircRNA</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - diagnosis</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Leukemia, Myeloid, Acute - mortality</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>Meta-analysis</subject><subject>Prognosis</subject><subject>RNA, Circular - genetics</subject><issn>0145-2126</issn><issn>1873-5835</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctu1DAUtRCITls-AeQlmwx2bMcxGzSqoCBVVKpmbzn2DXhI4sF2CvmK_jKOZmDL6r7OPfdxEHpNyZYS2rw7bAeYf0RI25rUvORkw9QztKGtZJVomXiONoRyUdW0bi7QZUoHQohQVL1EF0xJ0nLGN-hp_x2wn2wEk1YH5xLD72MhTj5MOPTY-mgfvu4SHs2CbZhy9N2cIeEcsMHHECI-xvBtCsmnlcHYUsXjAkPwDq9bwujNe7zDaUkZRpO9xREePfzCZnJ4hGwqM5lhKQTX6EVvhgSvzvYK7T993N98ru7ub7_c7O4qSxWnFW2FY6rpqeCUMCXA9tL2vBWKN7VreMtBNj2DjhIloSa2a01npGBMuJ44doXenmjL5j9nSFmPPlkYBjNBmJNmlEslRSt5gYoT1MaQUoReH6MfTVw0JXqVQh_0WQq9SqFPUpS-N-cRczeC-9f19_cF8OEEgHJn-UbUyXqYLDgfwWbtgv_PiD-8GJ7o</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Li, Meng</creator><creator>Zhang, Shiming</creator><creator>Wei, Junfan</creator><creator>Liu, Mengfei</creator><creator>Zhang, Bohao</creator><creator>Li, Shen</creator><creator>Xiao, Yue</creator><creator>Yu, Yuandong</creator><creator>Song, Ruipeng</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202501</creationdate><title>The increase in the expression of circRNAs may contributes to a poor prognosis in acute myeloid leukemia: A systematic review and meta-analysis</title><author>Li, Meng ; Zhang, Shiming ; Wei, Junfan ; Liu, Mengfei ; Zhang, Bohao ; Li, Shen ; Xiao, Yue ; Yu, Yuandong ; Song, Ruipeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1941-185d396f15410395ecf7cf4859462d6484e76f3eb1097e20cb8aba75335df0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Acute myeloid leukemia</topic><topic>Biomarkers, Tumor - genetics</topic><topic>CircRNA</topic><topic>Humans</topic><topic>Leukemia, Myeloid, Acute - diagnosis</topic><topic>Leukemia, Myeloid, Acute - genetics</topic><topic>Leukemia, Myeloid, Acute - mortality</topic><topic>Leukemia, Myeloid, Acute - pathology</topic><topic>Meta-analysis</topic><topic>Prognosis</topic><topic>RNA, Circular - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Meng</creatorcontrib><creatorcontrib>Zhang, Shiming</creatorcontrib><creatorcontrib>Wei, Junfan</creatorcontrib><creatorcontrib>Liu, Mengfei</creatorcontrib><creatorcontrib>Zhang, Bohao</creatorcontrib><creatorcontrib>Li, Shen</creatorcontrib><creatorcontrib>Xiao, Yue</creatorcontrib><creatorcontrib>Yu, Yuandong</creatorcontrib><creatorcontrib>Song, Ruipeng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Meng</au><au>Zhang, Shiming</au><au>Wei, Junfan</au><au>Liu, Mengfei</au><au>Zhang, Bohao</au><au>Li, Shen</au><au>Xiao, Yue</au><au>Yu, Yuandong</au><au>Song, Ruipeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The increase in the expression of circRNAs may contributes to a poor prognosis in acute myeloid leukemia: A systematic review and meta-analysis</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>2025-01</date><risdate>2025</risdate><volume>148</volume><spage>107639</spage><pages>107639-</pages><artnum>107639</artnum><issn>0145-2126</issn><issn>1873-5835</issn><eissn>1873-5835</eissn><abstract>The primary methods for defining the prognostic risk of AML patients are cytogenetic and molecular analysis at the time of diagnosis. However, the prognosis of intermediate-risk patients is still not well assessed for biomarkers. The main objective of this meta-analysis is to evaluate the relationship between circRNAs and AML prognosis, to provide a theoretical basis for finding effective prognostic indicators in intermediate-risk patients, and to provide an important scientific basis for the development or revision of WHO practice guidelines and ELN risk classification, and to highlight the importance of continuing to focus on and evaluate the prognostic impact of circRNAs on AML in future studies.
We performed a comprehensive literature search across PubMed, the Cochrane Library, and Web of Science databases for studies published up to September 15, 2024. Articles were selected based on inclusion criteria. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of studies. The outcome measure of overall survival (OS) was used, and hazard ratios (HR) and 95 % confidence intervals (CI) were pooled to estimate the relationship between circRNA expression and prognosis in AML using STATA 17.0 software.
A total of 13 studies involving 1401 AML patients were included. The studies showed a significantly increased hazard ratio (HR) of upregulated CircRNA expression for OS (HR=1.87, 95 % CI=1.51–2.32, P < 0.001). The results of subgroups analysis showed a significant increase in the hazard ratio (HR) for upregulation of CircRNA expression in EFS and circ_0012152（HR= 1.66, 95 % CI= 1.19–2.32, P < 0.005 and HR= 2.26,95 % CI= 1.27–4.00, P < 0.005), respectively. No significant heterogeneity or publication bias was detected.
Upregulated circRNA expression is significantly associated with poor prognosis in AML patients and may serve as a prognostic marker for AML.
•This study evaluated the relationship between circRNAs and AML prognosis.•Provide evidence for finding new prognostic indicators for intermediate-risk patients.•To provide a scientific basis for the development and revision of AML classification guidelines by the World Health Organization and the European Leukemia Network.•This study demonstrates that circRNAs expressed up-regulated in AML are associated with poor prognosis in AML patients.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39708434</pmid><doi>10.1016/j.leukres.2024.107639</doi></addata></record> |
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| subjects | Acute myeloid leukemia Biomarkers, Tumor - genetics CircRNA Humans Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - pathology Meta-analysis Prognosis RNA, Circular - genetics |
| title | The increase in the expression of circRNAs may contributes to a poor prognosis in acute myeloid leukemia: A systematic review and meta-analysis |
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