Transient receptor potential vanilloid 4 gene-deficiency attenuates the inhibitory effect of 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid on vascular permeability in mice
We investigated whether an anti-inflammatory lipid metabolite named 5,6-DiHETE reduces vascular permeability by inhibiting TRPV4 channels in vivo. In wild-type (WT) mice, histamine-induced dye extravasation was reduced by pre-administration of 5,6-DiHETE. In TRPV4-deficient mice, extravasation and h...
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| Veröffentlicht in: | Journal of pharmacological sciences 2025-01, Vol.157 (1), p.35-38 |
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| creator | Inoue, Kotoha Takenouchi, Shinya Kida, Misato Kashio, Makiko Tominaga, Makoto Murata, Takahisa |
| description | We investigated whether an anti-inflammatory lipid metabolite named 5,6-DiHETE reduces vascular permeability by inhibiting TRPV4 channels in vivo. In wild-type (WT) mice, histamine-induced dye extravasation was reduced by pre-administration of 5,6-DiHETE. In TRPV4-deficient mice, extravasation and histamine-induced edema were already reduced, and 5,6-DiHETE had no additional effect. In isolated WT aortas, 5,6-DiHETE attenuated acetylcholine-induced relaxation, but this effect was absent in TRPV4-deficient aortas. These findings suggest that 5,6-DiHETE reduces vascular permeability by inhibiting TRPV4 activity. |
| doi_str_mv | 10.1016/j.jphs.2024.11.005 |
| format | Article |
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In wild-type (WT) mice, histamine-induced dye extravasation was reduced by pre-administration of 5,6-DiHETE. In TRPV4-deficient mice, extravasation and histamine-induced edema were already reduced, and 5,6-DiHETE had no additional effect. In isolated WT aortas, 5,6-DiHETE attenuated acetylcholine-induced relaxation, but this effect was absent in TRPV4-deficient aortas. These findings suggest that 5,6-DiHETE reduces vascular permeability by inhibiting TRPV4 activity.</description><identifier>ISSN: 1347-8613</identifier><identifier>ISSN: 1347-8648</identifier><identifier>EISSN: 1347-8648</identifier><identifier>DOI: 10.1016/j.jphs.2024.11.005</identifier><identifier>PMID: 39706643</identifier><language>eng</language><publisher>Japan: Elsevier B.V</publisher><subject>5,6-DiHETE ; Animals ; Anti-Inflammatory Agents - pharmacology ; Aorta - drug effects ; Aorta - metabolism ; Arachidonic Acids - pharmacology ; Capillary Permeability - drug effects ; Edema - drug therapy ; Edema - genetics ; Histamine - metabolism ; Histamine - pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; TRPV Cation Channels - deficiency ; TRPV Cation Channels - genetics ; TRPV Cation Channels - metabolism ; TRPV4 ; Vascular permeability</subject><ispartof>Journal of pharmacological sciences, 2025-01, Vol.157 (1), p.35-38</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. 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These findings suggest that 5,6-DiHETE reduces vascular permeability by inhibiting TRPV4 activity.</description><subject>5,6-DiHETE</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Aorta - drug effects</subject><subject>Aorta - metabolism</subject><subject>Arachidonic Acids - pharmacology</subject><subject>Capillary Permeability - drug effects</subject><subject>Edema - drug therapy</subject><subject>Edema - genetics</subject><subject>Histamine - metabolism</subject><subject>Histamine - pharmacology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>TRPV Cation Channels - deficiency</subject><subject>TRPV Cation Channels - genetics</subject><subject>TRPV Cation Channels - metabolism</subject><subject>TRPV4</subject><subject>Vascular permeability</subject><issn>1347-8613</issn><issn>1347-8648</issn><issn>1347-8648</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhSMEoj_wAiyQlyya4L-JHYkNqoAiVWJTNt1YHvuauaMkHmynIm_FI-JhSpcsrmxL3znH9mmaN4x2jLL-_b7bH3a545TLjrGO0s2z5pwJqVrdS_38ac_EWXOR855SrqvuZXMmBkX7Xorz5vddsnNGmAtJ4OBQYiKHWOoZ7Uge7IzjGNETSX7ADK2HgK7SbiW2VGqxBTIpOyA473CLVb4SCAFcITGQzVXfetytPsVfa6vvrxirI-uo-xbQxVz1JVmYIzpiXQ2Kc03NbhltvQikCewWRyxrDSATOnjVvAh2zPD6cb1svn_-dHd9095--_L1-uNt67hmpd0MHrTqB8-5cEFpGBgMgoKkDILgW6WdHqRw1g_SKwvCC-s1H6xTYROCFJfNu5PvIcWfC-RiJswOxtHOEJdsBJNqUELwI8pPqEsx5wTBHBJONq2GUXNsyuzNsSlzbMowZmpTVfT20X_ZTuCfJP-qqcCHEwD1lQ8IyeS_Pw8ea1PF-Ij_8_8DipGn5A</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Inoue, Kotoha</creator><creator>Takenouchi, Shinya</creator><creator>Kida, Misato</creator><creator>Kashio, Makiko</creator><creator>Tominaga, Makoto</creator><creator>Murata, Takahisa</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3328-0796</orcidid></search><sort><creationdate>202501</creationdate><title>Transient receptor potential vanilloid 4 gene-deficiency attenuates the inhibitory effect of 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid on vascular permeability in mice</title><author>Inoue, Kotoha ; Takenouchi, Shinya ; Kida, Misato ; Kashio, Makiko ; Tominaga, Makoto ; Murata, Takahisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-59de8769d223cf78e91e930e401ef32b78c8943cad94d7ae3d3ad829ac7f5ff43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>5,6-DiHETE</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Aorta - drug effects</topic><topic>Aorta - metabolism</topic><topic>Arachidonic Acids - pharmacology</topic><topic>Capillary Permeability - drug effects</topic><topic>Edema - drug therapy</topic><topic>Edema - genetics</topic><topic>Histamine - metabolism</topic><topic>Histamine - pharmacology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>TRPV Cation Channels - deficiency</topic><topic>TRPV Cation Channels - genetics</topic><topic>TRPV Cation Channels - metabolism</topic><topic>TRPV4</topic><topic>Vascular permeability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inoue, Kotoha</creatorcontrib><creatorcontrib>Takenouchi, Shinya</creatorcontrib><creatorcontrib>Kida, Misato</creatorcontrib><creatorcontrib>Kashio, Makiko</creatorcontrib><creatorcontrib>Tominaga, Makoto</creatorcontrib><creatorcontrib>Murata, Takahisa</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inoue, Kotoha</au><au>Takenouchi, Shinya</au><au>Kida, Misato</au><au>Kashio, Makiko</au><au>Tominaga, Makoto</au><au>Murata, Takahisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transient receptor potential vanilloid 4 gene-deficiency attenuates the inhibitory effect of 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid on vascular permeability in mice</atitle><jtitle>Journal of pharmacological sciences</jtitle><addtitle>J Pharmacol Sci</addtitle><date>2025-01</date><risdate>2025</risdate><volume>157</volume><issue>1</issue><spage>35</spage><epage>38</epage><pages>35-38</pages><issn>1347-8613</issn><issn>1347-8648</issn><eissn>1347-8648</eissn><abstract>We investigated whether an anti-inflammatory lipid metabolite named 5,6-DiHETE reduces vascular permeability by inhibiting TRPV4 channels in vivo. 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| identifier | ISSN: 1347-8613 |
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| subjects | 5,6-DiHETE Animals Anti-Inflammatory Agents - pharmacology Aorta - drug effects Aorta - metabolism Arachidonic Acids - pharmacology Capillary Permeability - drug effects Edema - drug therapy Edema - genetics Histamine - metabolism Histamine - pharmacology Male Mice Mice, Inbred C57BL TRPV Cation Channels - deficiency TRPV Cation Channels - genetics TRPV Cation Channels - metabolism TRPV4 Vascular permeability |
| title | Transient receptor potential vanilloid 4 gene-deficiency attenuates the inhibitory effect of 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid on vascular permeability in mice |
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