De novo interleukin-10 production primed by Lactobacillus sakei CVL-001 amplifies the immunomodulatory abilities of mesenchymal stem cells to alleviate colitis

Mesenchymal stem cells (MSCs) hold therapeutic promise for treating inflammatory bowel disease (IBD) owing to their immunomodulatory properties. Currently, pre-conditioning strategies with several beneficial agents have been applied to enhance the efficacy of MSCs in treating IBDs. Probiotics are in...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2025-01, Vol.182, p.117745, Article 117745
Hauptverfasser:	Nguyen, Phuong Thao, Seo, Yoojin, Ahn, Ji-Su, Oh, Su-Jeong, Park, Hee-Jeong, Yu, Jeong Hyun, Kim, Seong Hui, Lee, Yunji, Yang, Ji Won, Cho, Jaejin, Kang, Min-Jung, Park, Jong-Hwan, Kim, Hyung-Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation - drug effects Colitis - chemically induced Colitis - immunology Colitis - microbiology Colitis - therapy Dextran Sulfate Disease Models, Animal Humans Immunomodulation Inflammatory Bowel Disease Interleukin-10 - metabolism Lactobacillus sakei CVL-001 Latilactobacillus sakei Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Male Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stem Cells Mesenchymal Stem Cells - immunology Mesenchymal Stem Cells - metabolism Mice Mice, Inbred C57BL Probiotics - pharmacology Regeneration
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