Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates

Despite their pivotal role, the evolutionary origins of vertebrate digestive systems remain enigmatic. We explored the cellular characteristics of the amphioxus ( ) digestive tract, a model for the presumed primitive chordate digestive system, using bulk tissue companioned with single-cell RNA seque...

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Veröffentlicht in:	Science advances 2024-12, Vol.10 (51), p.eadq0702
Hauptverfasser:	Dai, Yichen, Pan, Rongrong, Pan, Qi, Wu, Xiaotong, Cai, Zexin, Fu, Yongheng, Shi, Chenggang, Sheng, Yuyu, Li, Jingjing, Lin, Zhe, Liu, Gaoming, Zhu, Pingfen, Li, Meng, Li, Guang, Zhou, Xuming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Endocrine Cells - cytology Endocrine Cells - metabolism Gastrointestinal Tract - cytology Gastrointestinal Tract - metabolism Gene Expression Profiling Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Insulin - genetics Insulin - metabolism Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Lancelets - genetics Lancelets - metabolism Single-Cell Analysis - methods
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