Identification of Cysteine Metabolism Regulator (CymR)-Derived Pentapeptides as Nanomolar Inhibitors of Staphylococcus aureus O‑Acetyl‑l‑serine Sulfhydrylase (CysK)

The pathway of bacterial cysteine biosynthesis is gaining traction for the development of antibiotic adjuvants. Bacterial cysteine biosynthesis is generally facilitated by two enzymes possessing O-acetyl-l-serine sulfhydrylases (OASS), CysK and CysM. In Staphylococcus aureus, there exists a single O...

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Veröffentlicht in:	ACS infectious diseases 2025-01, Vol.11 (1), p.238-248
Hauptverfasser:	Pederick, Jordan L., Vandborg, Bethiney C., George, Amir, Bovermann, Hannah, Boyd, Jeffrey M., Freundlich, Joel S., Bruning, John B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Crystallography, X-Ray Cysteine - chemistry Cysteine - metabolism Cysteine Synthase - antagonists & inhibitors Cysteine Synthase - chemistry Cysteine Synthase - genetics Cysteine Synthase - metabolism Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Models, Molecular Staphylococcus aureus - drug effects Staphylococcus aureus - enzymology
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