Parasympathetic Dysfunction Prevails in GBA1-Associated Parkinson's Disease

The role played by sympathetic and parasympathetic autonomic branches in patients with Parkinson's disease carrying variants in the GBA1 gene (GBA-PD) is still elusive. To characterize cardiovascular autonomic function in GBA-PD and I-PD patients with early and mid-stage disease. These assessme...

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Veröffentlicht in:Movement disorders clinical practice (Hoboken, N.J.) N.J.), 2024-12
Hauptverfasser: De Santis, Tiziana, Cocco, Antoniangela, Castiglioni, Paolo, Ferrarin, Maurizio, Mineri, Rossana, Morenghi, Emanuela, Avenali, Micol, Albanese, Alberto
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container_title Movement disorders clinical practice (Hoboken, N.J.)
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creator De Santis, Tiziana
Cocco, Antoniangela
Castiglioni, Paolo
Ferrarin, Maurizio
Mineri, Rossana
Morenghi, Emanuela
Avenali, Micol
Albanese, Alberto
description The role played by sympathetic and parasympathetic autonomic branches in patients with Parkinson's disease carrying variants in the GBA1 gene (GBA-PD) is still elusive. To characterize cardiovascular autonomic function in GBA-PD and I-PD patients with early and mid-stage disease. These assessments were performed: cardiovascular autonomic tests, analysis of heart rate and blood pressure variability, cardiac noradrenergic imaging. The frequency and severity of autonomic symptoms were comparatively assessed with the SCOPA-AUT questionnaire. Compared to the I-PD cohort, GBA-PD patients displayed an increased burden of autonomic symptoms. Autonomic tests revealed worse parasympathetic scores in GBA-PD while sympathetic indexes and the degree of cardiac sympathetic binding were comparable in the two groups. Heart rate variability indexes also revealed lower vagal modulation in the GBA-PD group. The cardiovascular autonomic profile in GBA PD is characterized by a prominent cardiovagal dysfunction compared to I-PD.
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title Parasympathetic Dysfunction Prevails in GBA1-Associated Parkinson's Disease
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