Parasympathetic Dysfunction Prevails in GBA1-Associated Parkinson's Disease
The role played by sympathetic and parasympathetic autonomic branches in patients with Parkinson's disease carrying variants in the GBA1 gene (GBA-PD) is still elusive. To characterize cardiovascular autonomic function in GBA-PD and I-PD patients with early and mid-stage disease. These assessme...
Gespeichert in:
Veröffentlicht in: | Movement disorders clinical practice (Hoboken, N.J.) N.J.), 2024-12 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | |
container_start_page | |
container_title | Movement disorders clinical practice (Hoboken, N.J.) |
container_volume | |
creator | De Santis, Tiziana Cocco, Antoniangela Castiglioni, Paolo Ferrarin, Maurizio Mineri, Rossana Morenghi, Emanuela Avenali, Micol Albanese, Alberto |
description | The role played by sympathetic and parasympathetic autonomic branches in patients with Parkinson's disease carrying variants in the GBA1 gene (GBA-PD) is still elusive.
To characterize cardiovascular autonomic function in GBA-PD and I-PD patients with early and mid-stage disease.
These assessments were performed: cardiovascular autonomic tests, analysis of heart rate and blood pressure variability, cardiac noradrenergic imaging. The frequency and severity of autonomic symptoms were comparatively assessed with the SCOPA-AUT questionnaire.
Compared to the I-PD cohort, GBA-PD patients displayed an increased burden of autonomic symptoms. Autonomic tests revealed worse parasympathetic scores in GBA-PD while sympathetic indexes and the degree of cardiac sympathetic binding were comparable in the two groups. Heart rate variability indexes also revealed lower vagal modulation in the GBA-PD group.
The cardiovascular autonomic profile in GBA PD is characterized by a prominent cardiovagal dysfunction compared to I-PD. |
doi_str_mv | 10.1002/mdc3.14314 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3147485637</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3147485637</sourcerecordid><originalsourceid>FETCH-LOGICAL-c176t-b9df62112aab432b680bbda35fb4fca5e085b945aa6eceeda4482c530d3ad3873</originalsourceid><addsrcrecordid>eNpNkEtPwkAUhSdGIwTZ-ANMdxqT4rz6WiIoGklkoevmzsxtHO0De1sT_r0gaFyds_jOWXyMnQs-EZzLm8pZNRFaCX3EhlIpHopYZMf_-oCNid4550JGMZfilA1UlnCtlByypxW0QJtqDd0bdt4G8w0VfW0739TBqsUv8CUFvg4Wt1MRToka66FDF2x3H76mpr6kYO4JgfCMnRRQEo4POWKv93cvs4dw-bx4nE2XoRVJ3IUmc0UshZAARitp4pQb40BFhdGFhQh5GplMRwAxWkQHWqfSRoo7BU6liRqxq_3vum0-e6QurzxZLEuosekp37pIdBrFaode71HbNkQtFvm69RW0m1zwfOcv3_nLf_xt4YvDb28qdH_ory31DWeSaxA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3147485637</pqid></control><display><type>article</type><title>Parasympathetic Dysfunction Prevails in GBA1-Associated Parkinson's Disease</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>De Santis, Tiziana ; Cocco, Antoniangela ; Castiglioni, Paolo ; Ferrarin, Maurizio ; Mineri, Rossana ; Morenghi, Emanuela ; Avenali, Micol ; Albanese, Alberto</creator><creatorcontrib>De Santis, Tiziana ; Cocco, Antoniangela ; Castiglioni, Paolo ; Ferrarin, Maurizio ; Mineri, Rossana ; Morenghi, Emanuela ; Avenali, Micol ; Albanese, Alberto</creatorcontrib><description>The role played by sympathetic and parasympathetic autonomic branches in patients with Parkinson's disease carrying variants in the GBA1 gene (GBA-PD) is still elusive.
To characterize cardiovascular autonomic function in GBA-PD and I-PD patients with early and mid-stage disease.
These assessments were performed: cardiovascular autonomic tests, analysis of heart rate and blood pressure variability, cardiac noradrenergic imaging. The frequency and severity of autonomic symptoms were comparatively assessed with the SCOPA-AUT questionnaire.
Compared to the I-PD cohort, GBA-PD patients displayed an increased burden of autonomic symptoms. Autonomic tests revealed worse parasympathetic scores in GBA-PD while sympathetic indexes and the degree of cardiac sympathetic binding were comparable in the two groups. Heart rate variability indexes also revealed lower vagal modulation in the GBA-PD group.
The cardiovascular autonomic profile in GBA PD is characterized by a prominent cardiovagal dysfunction compared to I-PD.</description><identifier>ISSN: 2330-1619</identifier><identifier>EISSN: 2330-1619</identifier><identifier>DOI: 10.1002/mdc3.14314</identifier><identifier>PMID: 39704332</identifier><language>eng</language><publisher>United States</publisher><ispartof>Movement disorders clinical practice (Hoboken, N.J.), 2024-12</ispartof><rights>2024 International Parkinson and Movement Disorder Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c176t-b9df62112aab432b680bbda35fb4fca5e085b945aa6eceeda4482c530d3ad3873</cites><orcidid>0000-0001-7591-7428 ; 0000-0002-5864-0006</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39704332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Santis, Tiziana</creatorcontrib><creatorcontrib>Cocco, Antoniangela</creatorcontrib><creatorcontrib>Castiglioni, Paolo</creatorcontrib><creatorcontrib>Ferrarin, Maurizio</creatorcontrib><creatorcontrib>Mineri, Rossana</creatorcontrib><creatorcontrib>Morenghi, Emanuela</creatorcontrib><creatorcontrib>Avenali, Micol</creatorcontrib><creatorcontrib>Albanese, Alberto</creatorcontrib><title>Parasympathetic Dysfunction Prevails in GBA1-Associated Parkinson's Disease</title><title>Movement disorders clinical practice (Hoboken, N.J.)</title><addtitle>Mov Disord Clin Pract</addtitle><description>The role played by sympathetic and parasympathetic autonomic branches in patients with Parkinson's disease carrying variants in the GBA1 gene (GBA-PD) is still elusive.
To characterize cardiovascular autonomic function in GBA-PD and I-PD patients with early and mid-stage disease.
These assessments were performed: cardiovascular autonomic tests, analysis of heart rate and blood pressure variability, cardiac noradrenergic imaging. The frequency and severity of autonomic symptoms were comparatively assessed with the SCOPA-AUT questionnaire.
Compared to the I-PD cohort, GBA-PD patients displayed an increased burden of autonomic symptoms. Autonomic tests revealed worse parasympathetic scores in GBA-PD while sympathetic indexes and the degree of cardiac sympathetic binding were comparable in the two groups. Heart rate variability indexes also revealed lower vagal modulation in the GBA-PD group.
The cardiovascular autonomic profile in GBA PD is characterized by a prominent cardiovagal dysfunction compared to I-PD.</description><issn>2330-1619</issn><issn>2330-1619</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpNkEtPwkAUhSdGIwTZ-ANMdxqT4rz6WiIoGklkoevmzsxtHO0De1sT_r0gaFyds_jOWXyMnQs-EZzLm8pZNRFaCX3EhlIpHopYZMf_-oCNid4550JGMZfilA1UlnCtlByypxW0QJtqDd0bdt4G8w0VfW0739TBqsUv8CUFvg4Wt1MRToka66FDF2x3H76mpr6kYO4JgfCMnRRQEo4POWKv93cvs4dw-bx4nE2XoRVJ3IUmc0UshZAARitp4pQb40BFhdGFhQh5GplMRwAxWkQHWqfSRoo7BU6liRqxq_3vum0-e6QurzxZLEuosekp37pIdBrFaode71HbNkQtFvm69RW0m1zwfOcv3_nLf_xt4YvDb28qdH_ory31DWeSaxA</recordid><startdate>20241220</startdate><enddate>20241220</enddate><creator>De Santis, Tiziana</creator><creator>Cocco, Antoniangela</creator><creator>Castiglioni, Paolo</creator><creator>Ferrarin, Maurizio</creator><creator>Mineri, Rossana</creator><creator>Morenghi, Emanuela</creator><creator>Avenali, Micol</creator><creator>Albanese, Alberto</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7591-7428</orcidid><orcidid>https://orcid.org/0000-0002-5864-0006</orcidid></search><sort><creationdate>20241220</creationdate><title>Parasympathetic Dysfunction Prevails in GBA1-Associated Parkinson's Disease</title><author>De Santis, Tiziana ; Cocco, Antoniangela ; Castiglioni, Paolo ; Ferrarin, Maurizio ; Mineri, Rossana ; Morenghi, Emanuela ; Avenali, Micol ; Albanese, Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c176t-b9df62112aab432b680bbda35fb4fca5e085b945aa6eceeda4482c530d3ad3873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Santis, Tiziana</creatorcontrib><creatorcontrib>Cocco, Antoniangela</creatorcontrib><creatorcontrib>Castiglioni, Paolo</creatorcontrib><creatorcontrib>Ferrarin, Maurizio</creatorcontrib><creatorcontrib>Mineri, Rossana</creatorcontrib><creatorcontrib>Morenghi, Emanuela</creatorcontrib><creatorcontrib>Avenali, Micol</creatorcontrib><creatorcontrib>Albanese, Alberto</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Movement disorders clinical practice (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Santis, Tiziana</au><au>Cocco, Antoniangela</au><au>Castiglioni, Paolo</au><au>Ferrarin, Maurizio</au><au>Mineri, Rossana</au><au>Morenghi, Emanuela</au><au>Avenali, Micol</au><au>Albanese, Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parasympathetic Dysfunction Prevails in GBA1-Associated Parkinson's Disease</atitle><jtitle>Movement disorders clinical practice (Hoboken, N.J.)</jtitle><addtitle>Mov Disord Clin Pract</addtitle><date>2024-12-20</date><risdate>2024</risdate><issn>2330-1619</issn><eissn>2330-1619</eissn><abstract>The role played by sympathetic and parasympathetic autonomic branches in patients with Parkinson's disease carrying variants in the GBA1 gene (GBA-PD) is still elusive.
To characterize cardiovascular autonomic function in GBA-PD and I-PD patients with early and mid-stage disease.
These assessments were performed: cardiovascular autonomic tests, analysis of heart rate and blood pressure variability, cardiac noradrenergic imaging. The frequency and severity of autonomic symptoms were comparatively assessed with the SCOPA-AUT questionnaire.
Compared to the I-PD cohort, GBA-PD patients displayed an increased burden of autonomic symptoms. Autonomic tests revealed worse parasympathetic scores in GBA-PD while sympathetic indexes and the degree of cardiac sympathetic binding were comparable in the two groups. Heart rate variability indexes also revealed lower vagal modulation in the GBA-PD group.
The cardiovascular autonomic profile in GBA PD is characterized by a prominent cardiovagal dysfunction compared to I-PD.</abstract><cop>United States</cop><pmid>39704332</pmid><doi>10.1002/mdc3.14314</doi><orcidid>https://orcid.org/0000-0001-7591-7428</orcidid><orcidid>https://orcid.org/0000-0002-5864-0006</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2330-1619 |
ispartof | Movement disorders clinical practice (Hoboken, N.J.), 2024-12 |
issn | 2330-1619 2330-1619 |
language | eng |
recordid | cdi_proquest_miscellaneous_3147485637 |
source | Wiley Online Library Journals Frontfile Complete |
title | Parasympathetic Dysfunction Prevails in GBA1-Associated Parkinson's Disease |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T06%3A28%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Parasympathetic%20Dysfunction%20Prevails%20in%20GBA1-Associated%20Parkinson's%20Disease&rft.jtitle=Movement%20disorders%20clinical%20practice%20(Hoboken,%20N.J.)&rft.au=De%20Santis,%20Tiziana&rft.date=2024-12-20&rft.issn=2330-1619&rft.eissn=2330-1619&rft_id=info:doi/10.1002/mdc3.14314&rft_dat=%3Cproquest_cross%3E3147485637%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3147485637&rft_id=info:pmid/39704332&rfr_iscdi=true |