Enhanced Oral Bioavailability and Biodistribution of Voriconazole through Zein-Pectin-Hyaluronic Acid Nanoparticles

Nanotechnology-based drug delivery systems offer a solution to the pharmacokinetic limitations of voriconazole (VRC), including saturable metabolism and low oral bioavailability. This study developed zein/pectin/hyaluronic acid nanoparticles (ZPHA-VRC NPs) to improve VRC’s pharmacokinetics and biodi...

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Veröffentlicht in:	ACS applied materials & interfaces 2025-01, Vol.17 (1), p.513-523
Hauptverfasser:	Fin, Margani Taise, Diedrich, Camila, Machado, Christiane Schineider, da Silva, Letícia Marina, Tartari, Ana Paula Santos, Zittlau, Isabella Camargo, Peczek, Samila Horst, Mainardes, Rubiana Mara
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antifungal Agents - administration & dosage Antifungal Agents - chemistry Antifungal Agents - pharmacokinetics Biological and Medical Applications of Materials and Interfaces Biological Availability Drug Carriers - chemistry Hyaluronic Acid - chemistry Hyaluronic Acid - pharmacokinetics Male Nanoparticles - chemistry Pectins - chemistry Rats Rats, Sprague-Dawley Tissue Distribution Voriconazole - administration & dosage Voriconazole - chemistry Voriconazole - pharmacokinetics Zein - chemistry Zein - pharmacokinetics
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