Plasma metabolomic signatures after oral administration of ritonavir in COVID-19 treatment via chemometrics-assisted UPLC/Q-TOF/MS/MS

Understanding the pharmacodynamics of ritonavir through metabolomics offers insights into its side effects and helps in the development of safer therapies. This study aimed to investigate the effects of ritonavir treatment on the metabolic profiles of rabbits via a metabolomics approach, with the ob...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2025-03, Vol.255, p.116638, Article 116638
Hauptverfasser:	Demirkaya Miloglu, Fatma, Bayrak, Burak, Yuksel, Busra, Demir, Sema Nur, Gundogdu, Gulsah, Kadioglu, Yucel, Abd El-Aty, A.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biomarkers - blood Chromatography, High Pressure Liquid - methods COVID-19 COVID-19 Drug Treatment Male Metabolic Networks and Pathways - drug effects Metabolome - drug effects Metabolomics Metabolomics - methods Multivariate data analysis Pathway analysis Principal Component Analysis Rabbits Ritonavir Ritonavir - administration & dosage Ritonavir - pharmacology Tandem Mass Spectrometry - methods UPLC/Q-TOF/MS/MS
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