Transferrin Protein Corona-Targeted Codelivery of Tirapazamine and IR820 Facilitates Efficient PDT-Induced Hypoxic Chemotherapy on 4T1 Breast Cancer

Protein corona (PC) formation confers novel biological properties to the original nanomaterial, impeding its uptake and targeting efficacy in cells and tissues. Although many studies discussing PC formation have focused on inert proteins that may inhibit the function of nanomaterials, some functiona...

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Veröffentlicht in:	ACS applied materials & interfaces 2025-01, Vol.17 (1), p.1892-1910
Hauptverfasser:	Jin, Mingji, Wu, Hao, Jin, Wenyu, Zeng, Bowen, Liu, Yanhong, Wang, Nuoya, Wang, Shuangqing, Chen, Liqing, Gao, Zhonggao, Huang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Female Functional Nanostructured Materials (including low-D carbon) Humans Indocyanine Green - analogs & derivatives Indocyanine Green - chemistry Indocyanine Green - pharmacology Liposomes - chemistry Mice Mice, Inbred BALB C Nanoparticles - chemistry Photochemotherapy Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Protein Corona - chemistry Silicon Dioxide - chemistry Tirapazamine - chemistry Tirapazamine - pharmacology Transferrin - chemistry
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