Neddylation drives myofibrillogenesis in the developing heart

Neddylation is a highly conserved post‐translational modification that plays critical roles in various cellular processes through the modulation of cullins and non‐cullin substrates. While neddylation is known to be essential for embryonic development, tumor growth, and organogenesis of different ti...

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Veröffentlicht in:	The FASEB journal 2024-12, Vol.38 (24), p.e70260-n/a
Hauptverfasser:	Littlejohn, Rodney, Zambrano‐Carrasco, Josue, Zou, Jianqiu, Lu, Yi, Liu, Elise, Kim, Il‐man, Jiao, Kai, Weintraub, Neal L., Zhou, Jiliang, Li, Jie, Su, Huabo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cardiac development Cell Proliferation Female Gene Expression Regulation, Developmental Heart - embryology Heart - growth & development Mice Mice, Knockout Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology myofibril assembly Myofibrils - metabolism Myofibrils - pathology NAE1 NEDD8 Protein - genetics NEDD8 Protein - metabolism Neddylation Organogenesis Protein Processing, Post-Translational Ubiquitin-Activating Enzymes - genetics Ubiquitin-Activating Enzymes - metabolism
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