Sex-specific mechanisms of cerebral microvascular BKCa dysfunction in a mouse model of Alzheimer's disease

Cerebrovascular dysfunction occurs in Alzheimer's disease (AD), impairing hemodynamic regulation. Large conductance Ca2+-activated K+ channels (BKCa) regulate cerebrovascular reactivity and are impaired in AD. BKCa activity depends on intracellular Ca2+ (Ca2+ sparks) and nitro-oxidative post-tr...

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Veröffentlicht in:	Alzheimer's & dementia 2024-12
Hauptverfasser:	Silva, Josiane F, Polk, Felipe D, Martin, Paige E, Thai, Stephenie H, Savu, Andrea, Gonzales, Matthew, Kath, Allison M, Gee, Michael T, Pires, Paulo W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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