Exosomal miR-146a-5p derived from bone marrow mesenchymal stromal cells regulate Th1/Th2 balance and alleviates immune thrombocytopenia in pregnancy

Immune thrombocytopenia (ITP) is a common hematological disorder. Our previous study has found that exosomal miR-146a-5p derived from bone marrow mesenchymal stromal cells (BMSCs) regulate Th17/Treg balance to alleviate ITP. This work further investigated the role of miR-146a-5p in ITP with pregnanc...

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Veröffentlicht in:	Human cell : official journal of Human Cell Research Society 2024-12, Vol.38 (1), p.31, Article 31
Hauptverfasser:	Rong, Yanyan, Lu, Wei, Huang, Xianbao, Ji, Dexiang, Tang, Dehong, Huang, Ruibin, Zhou, Wenhua, Chen, Guoan, He, Yue
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomedical and Life Sciences Bone marrow CD4 antigen Cell Biology Cell proliferation Cells, Cultured Disease Models, Animal Exosomes Exosomes - metabolism Female Gynecology Helper cells Hematological diseases Humans Idiopathic thrombocytopenic purpura Life Sciences Lymphocytes T Mesenchymal Stem Cells Mice MicroRNAs - genetics MicroRNAs - physiology NF-kappa B - metabolism NF-κB protein Oncology Peripheral blood Pregnancy Pregnancy Complications, Hematologic - genetics Pregnancy Complications, Hematologic - therapy Purpura, Thrombocytopenic, Idiopathic - genetics Purpura, Thrombocytopenic, Idiopathic - immunology Purpura, Thrombocytopenic, Idiopathic - therapy Reproductive Medicine Research Article Signal transduction Signal Transduction - genetics Stem Cells Stromal cells Surgery Th1 Cells - immunology Th1-Th2 Balance Th2 Cells - immunology Thrombocytopenia γ-Interferon
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