Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study
Acute and chronic pancreatitis (CP) are inflammatory conditions of the pancreas that cause local and systemic complications. The epidemiology of these conditions are not well-known in India. We describe the protocol and procedures of a multicentre study for delineating the epidemiology of pancreatit...
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| Veröffentlicht in: | BMJ open gastroenterology 2024-12, Vol.11 (1), p.e001562 |
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| creator | Krishnan, Anand Pillai, Divya Amarchand, Ritvik Agarwal, Ashish Ahuja, Vineet Baloni, Vineeta Basu, Subhra Samujjwal Bhardwaj, Pankaj Choudhury, Bikash Chowdhury, Sudipta Dhar Dabar, Deepti Das, Soumi Deshmukh, Pradeep Devadas, Krishnadas Dhali, Gopal Krishna Gunjan, Deepak Gupta, Anmol Jain, Saransh Kedia, Saurabh Kumar, Rakesh Kumar, Sanjeev Makharia, Govind K Monga, Nitika Rungta, Sumit Saraya, Anoop Sarkar, Rajib Shalimar Sharma, Brij Singh, Shivendra Sujatha, Chintha Wadhwa, Nitya Garg, Pramod Kumar |
| description | Acute and chronic pancreatitis (CP) are inflammatory conditions of the pancreas that cause local and systemic complications. The epidemiology of these conditions are not well-known in India.
We describe the protocol and procedures of a multicentre study for delineating the epidemiology of pancreatitis in India. We plan to cover 110 000 people across 10 geographically distributed sites in 10 states of India to estimate the burden and risk factors of CP. Trained investigators will make house visits and screen for abdominal pain requiring hospitalisation or pre-diagnosed CP. The screened positive participants will be reviewed by a gastroenterologist to confirm the diagnosis of CP based on radiological imaging. For each case, four controls will be selected and data on risk factors for CP (tobacco, alcohol, family history, metabolic causes) and blood for genetic markers will be collected. Information on the cost of treatment and quality of life will be collected from patients with CP. For estimating incidence of acute pancreatitis (AP), hospital-based sentinel surveillance will be conducted in 10 districts across these 10 states. All hospitals in the district will be contacted to provide a line list of admissions due to acute abdomen including AP for 2 years. The spread of acute abdomen cases will be used to define the catchment area and estimate the denominator population. The line-listed cases with AP living in the catchment area will form the numerator to calculate the incidence. The study will provide critical information for planning pancreatitis-related services in the country.
The institutional ethics committee (IECs) at all the participating sites have given their approval for the study. All the participants whose data will be collected will be included after written informed consent. The results may be presented at national or international conferences and will be reported in peer-reviewed publications. |
| doi_str_mv | 10.1136/bmjgast-2024-001562 |
| format | Article |
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We describe the protocol and procedures of a multicentre study for delineating the epidemiology of pancreatitis in India. We plan to cover 110 000 people across 10 geographically distributed sites in 10 states of India to estimate the burden and risk factors of CP. Trained investigators will make house visits and screen for abdominal pain requiring hospitalisation or pre-diagnosed CP. The screened positive participants will be reviewed by a gastroenterologist to confirm the diagnosis of CP based on radiological imaging. For each case, four controls will be selected and data on risk factors for CP (tobacco, alcohol, family history, metabolic causes) and blood for genetic markers will be collected. Information on the cost of treatment and quality of life will be collected from patients with CP. For estimating incidence of acute pancreatitis (AP), hospital-based sentinel surveillance will be conducted in 10 districts across these 10 states. All hospitals in the district will be contacted to provide a line list of admissions due to acute abdomen including AP for 2 years. The spread of acute abdomen cases will be used to define the catchment area and estimate the denominator population. The line-listed cases with AP living in the catchment area will form the numerator to calculate the incidence. The study will provide critical information for planning pancreatitis-related services in the country.
The institutional ethics committee (IECs) at all the participating sites have given their approval for the study. All the participants whose data will be collected will be included after written informed consent. The results may be presented at national or international conferences and will be reported in peer-reviewed publications.</description><identifier>ISSN: 2054-4774</identifier><identifier>EISSN: 2054-4774</identifier><identifier>DOI: 10.1136/bmjgast-2024-001562</identifier><identifier>PMID: 39694625</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Abdomen ; Acute Disease ; Diabetes ; Epidemiology ; Female ; Health risk assessment ; Hospitalization - statistics & numerical data ; Hospitals ; Humans ; Incidence ; India - epidemiology ; Male ; Multicenter Studies as Topic ; Pain ; Pancreatitis ; Pancreatitis - epidemiology ; Pancreatitis, Chronic - epidemiology ; Population-based studies ; Quality of Life ; Research Design ; Risk Factors ; Sample size ; Sentinel Surveillance</subject><ispartof>BMJ open gastroenterology, 2024-12, Vol.11 (1), p.e001562</ispartof><rights>Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2024 Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-9173-7811 ; 0000-0002-0609-3135</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39694625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krishnan, Anand</creatorcontrib><creatorcontrib>Pillai, Divya</creatorcontrib><creatorcontrib>Amarchand, Ritvik</creatorcontrib><creatorcontrib>Agarwal, Ashish</creatorcontrib><creatorcontrib>Ahuja, Vineet</creatorcontrib><creatorcontrib>Baloni, Vineeta</creatorcontrib><creatorcontrib>Basu, Subhra Samujjwal</creatorcontrib><creatorcontrib>Bhardwaj, Pankaj</creatorcontrib><creatorcontrib>Choudhury, Bikash</creatorcontrib><creatorcontrib>Chowdhury, Sudipta Dhar</creatorcontrib><creatorcontrib>Dabar, Deepti</creatorcontrib><creatorcontrib>Das, Soumi</creatorcontrib><creatorcontrib>Deshmukh, Pradeep</creatorcontrib><creatorcontrib>Devadas, Krishnadas</creatorcontrib><creatorcontrib>Dhali, Gopal Krishna</creatorcontrib><creatorcontrib>Gunjan, Deepak</creatorcontrib><creatorcontrib>Gupta, Anmol</creatorcontrib><creatorcontrib>Jain, Saransh</creatorcontrib><creatorcontrib>Kedia, Saurabh</creatorcontrib><creatorcontrib>Kumar, Rakesh</creatorcontrib><creatorcontrib>Kumar, Sanjeev</creatorcontrib><creatorcontrib>Makharia, Govind K</creatorcontrib><creatorcontrib>Monga, Nitika</creatorcontrib><creatorcontrib>Rungta, Sumit</creatorcontrib><creatorcontrib>Saraya, Anoop</creatorcontrib><creatorcontrib>Sarkar, Rajib</creatorcontrib><creatorcontrib>Shalimar</creatorcontrib><creatorcontrib>Sharma, Brij</creatorcontrib><creatorcontrib>Singh, Shivendra</creatorcontrib><creatorcontrib>Sujatha, Chintha</creatorcontrib><creatorcontrib>Wadhwa, Nitya</creatorcontrib><creatorcontrib>Garg, Pramod Kumar</creatorcontrib><title>Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study</title><title>BMJ open gastroenterology</title><addtitle>BMJ Open Gastroenterol</addtitle><description>Acute and chronic pancreatitis (CP) are inflammatory conditions of the pancreas that cause local and systemic complications. The epidemiology of these conditions are not well-known in India.
We describe the protocol and procedures of a multicentre study for delineating the epidemiology of pancreatitis in India. We plan to cover 110 000 people across 10 geographically distributed sites in 10 states of India to estimate the burden and risk factors of CP. Trained investigators will make house visits and screen for abdominal pain requiring hospitalisation or pre-diagnosed CP. The screened positive participants will be reviewed by a gastroenterologist to confirm the diagnosis of CP based on radiological imaging. For each case, four controls will be selected and data on risk factors for CP (tobacco, alcohol, family history, metabolic causes) and blood for genetic markers will be collected. Information on the cost of treatment and quality of life will be collected from patients with CP. For estimating incidence of acute pancreatitis (AP), hospital-based sentinel surveillance will be conducted in 10 districts across these 10 states. All hospitals in the district will be contacted to provide a line list of admissions due to acute abdomen including AP for 2 years. The spread of acute abdomen cases will be used to define the catchment area and estimate the denominator population. The line-listed cases with AP living in the catchment area will form the numerator to calculate the incidence. The study will provide critical information for planning pancreatitis-related services in the country.
The institutional ethics committee (IECs) at all the participating sites have given their approval for the study. All the participants whose data will be collected will be included after written informed consent. The results may be presented at national or international conferences and will be reported in peer-reviewed publications.</description><subject>Abdomen</subject><subject>Acute Disease</subject><subject>Diabetes</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Incidence</subject><subject>India - epidemiology</subject><subject>Male</subject><subject>Multicenter Studies as Topic</subject><subject>Pain</subject><subject>Pancreatitis</subject><subject>Pancreatitis - epidemiology</subject><subject>Pancreatitis, Chronic - epidemiology</subject><subject>Population-based studies</subject><subject>Quality of Life</subject><subject>Research Design</subject><subject>Risk Factors</subject><subject>Sample size</subject><subject>Sentinel Surveillance</subject><issn>2054-4774</issn><issn>2054-4774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0E9LwzAYBvAgihtzn0CQgJd5qOZ_Om8ypg4G7rB7SdNky2iT2qSHfXvrnCCe3veFHw8PLwC3GD1iTMVT2Rx2KqaMIMIyhDAX5AKMCeIsY1Kyyz_7CExjPKBvRBkh-TUY0bmYM0H4GOyXratM40IddkcYLNT7LninofIVVLpPBrbK686o5JKL0Hm48pVTcLbcrBYvm-x0PTzDtgsp6FBDGzqoYNPXyWnjU2dgTH11vAFXVtXRTM9zAravy-3iPVt_vA1B66zNGc-EsJzkWOWitCafE8VxyY20WgqiNcoJpZVSlc6xtNySinBrjWREaipyoySdgNlP7NDnszcxFY2L2tS18ib0saCYSUwRpXig9__oIfSdH8qdlERcyvmg7s6qLxtTFW3nGtUdi98X0i90nXS4</recordid><startdate>20241218</startdate><enddate>20241218</enddate><creator>Krishnan, Anand</creator><creator>Pillai, Divya</creator><creator>Amarchand, Ritvik</creator><creator>Agarwal, Ashish</creator><creator>Ahuja, Vineet</creator><creator>Baloni, Vineeta</creator><creator>Basu, Subhra Samujjwal</creator><creator>Bhardwaj, Pankaj</creator><creator>Choudhury, Bikash</creator><creator>Chowdhury, Sudipta Dhar</creator><creator>Dabar, Deepti</creator><creator>Das, Soumi</creator><creator>Deshmukh, Pradeep</creator><creator>Devadas, Krishnadas</creator><creator>Dhali, Gopal Krishna</creator><creator>Gunjan, Deepak</creator><creator>Gupta, Anmol</creator><creator>Jain, Saransh</creator><creator>Kedia, Saurabh</creator><creator>Kumar, Rakesh</creator><creator>Kumar, Sanjeev</creator><creator>Makharia, Govind K</creator><creator>Monga, Nitika</creator><creator>Rungta, Sumit</creator><creator>Saraya, Anoop</creator><creator>Sarkar, Rajib</creator><creator>Shalimar</creator><creator>Sharma, Brij</creator><creator>Singh, Shivendra</creator><creator>Sujatha, Chintha</creator><creator>Wadhwa, Nitya</creator><creator>Garg, Pramod Kumar</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9173-7811</orcidid><orcidid>https://orcid.org/0000-0002-0609-3135</orcidid></search><sort><creationdate>20241218</creationdate><title>Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study</title><author>Krishnan, Anand ; Pillai, Divya ; Amarchand, Ritvik ; Agarwal, Ashish ; Ahuja, Vineet ; Baloni, Vineeta ; Basu, Subhra Samujjwal ; Bhardwaj, Pankaj ; Choudhury, Bikash ; Chowdhury, Sudipta Dhar ; Dabar, Deepti ; Das, Soumi ; Deshmukh, Pradeep ; Devadas, Krishnadas ; Dhali, Gopal Krishna ; Gunjan, Deepak ; Gupta, Anmol ; Jain, Saransh ; Kedia, Saurabh ; Kumar, Rakesh ; Kumar, Sanjeev ; Makharia, Govind K ; Monga, Nitika ; Rungta, Sumit ; Saraya, Anoop ; Sarkar, Rajib ; Shalimar ; Sharma, Brij ; Singh, Shivendra ; Sujatha, Chintha ; Wadhwa, Nitya ; Garg, Pramod Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p845-66f5281a86bfe892a51b5e7fc762cc08233daadc817f5f2d25ffe7427c368ea73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abdomen</topic><topic>Acute Disease</topic><topic>Diabetes</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Hospitalization - 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Academic</collection><jtitle>BMJ open gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krishnan, Anand</au><au>Pillai, Divya</au><au>Amarchand, Ritvik</au><au>Agarwal, Ashish</au><au>Ahuja, Vineet</au><au>Baloni, Vineeta</au><au>Basu, Subhra Samujjwal</au><au>Bhardwaj, Pankaj</au><au>Choudhury, Bikash</au><au>Chowdhury, Sudipta Dhar</au><au>Dabar, Deepti</au><au>Das, Soumi</au><au>Deshmukh, Pradeep</au><au>Devadas, Krishnadas</au><au>Dhali, Gopal Krishna</au><au>Gunjan, Deepak</au><au>Gupta, Anmol</au><au>Jain, Saransh</au><au>Kedia, Saurabh</au><au>Kumar, Rakesh</au><au>Kumar, Sanjeev</au><au>Makharia, Govind K</au><au>Monga, Nitika</au><au>Rungta, Sumit</au><au>Saraya, Anoop</au><au>Sarkar, Rajib</au><au>Shalimar</au><au>Sharma, Brij</au><au>Singh, Shivendra</au><au>Sujatha, Chintha</au><au>Wadhwa, Nitya</au><au>Garg, Pramod Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study</atitle><jtitle>BMJ open gastroenterology</jtitle><addtitle>BMJ Open Gastroenterol</addtitle><date>2024-12-18</date><risdate>2024</risdate><volume>11</volume><issue>1</issue><spage>e001562</spage><pages>e001562-</pages><issn>2054-4774</issn><eissn>2054-4774</eissn><abstract>Acute and chronic pancreatitis (CP) are inflammatory conditions of the pancreas that cause local and systemic complications. The epidemiology of these conditions are not well-known in India.
We describe the protocol and procedures of a multicentre study for delineating the epidemiology of pancreatitis in India. We plan to cover 110 000 people across 10 geographically distributed sites in 10 states of India to estimate the burden and risk factors of CP. Trained investigators will make house visits and screen for abdominal pain requiring hospitalisation or pre-diagnosed CP. The screened positive participants will be reviewed by a gastroenterologist to confirm the diagnosis of CP based on radiological imaging. For each case, four controls will be selected and data on risk factors for CP (tobacco, alcohol, family history, metabolic causes) and blood for genetic markers will be collected. Information on the cost of treatment and quality of life will be collected from patients with CP. For estimating incidence of acute pancreatitis (AP), hospital-based sentinel surveillance will be conducted in 10 districts across these 10 states. All hospitals in the district will be contacted to provide a line list of admissions due to acute abdomen including AP for 2 years. The spread of acute abdomen cases will be used to define the catchment area and estimate the denominator population. The line-listed cases with AP living in the catchment area will form the numerator to calculate the incidence. The study will provide critical information for planning pancreatitis-related services in the country.
The institutional ethics committee (IECs) at all the participating sites have given their approval for the study. All the participants whose data will be collected will be included after written informed consent. The results may be presented at national or international conferences and will be reported in peer-reviewed publications.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>39694625</pmid><doi>10.1136/bmjgast-2024-001562</doi><orcidid>https://orcid.org/0000-0002-9173-7811</orcidid><orcidid>https://orcid.org/0000-0002-0609-3135</orcidid></addata></record> |
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| ispartof | BMJ open gastroenterology, 2024-12, Vol.11 (1), p.e001562 |
| issn | 2054-4774 2054-4774 |
| language | eng |
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| source | BMJ Open Access Journals; MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Abdomen Acute Disease Diabetes Epidemiology Female Health risk assessment Hospitalization - statistics & numerical data Hospitals Humans Incidence India - epidemiology Male Multicenter Studies as Topic Pain Pancreatitis Pancreatitis - epidemiology Pancreatitis, Chronic - epidemiology Population-based studies Quality of Life Research Design Risk Factors Sample size Sentinel Surveillance |
| title | Epidemiology of chronic and acute pancreatitis in India (EPICAP-India): protocol for a multicentre study |
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