Hyperbaric oxygen therapy prevents epithelial atrophy in distal tubules and TGF-β1 overexpression in diabetic rat kidneys
Diabetic nephropathy (DN) is one of the most relevant and prevalent microvascular complications associated with Diabetes Mellitus. In recent years, hyperbaric oxygen therapy (HBO) has been used to mitigate tissue damage caused by hypoxia, thereby attenuating inflammatory processes. This study aimed...
Gespeichert in:
| Veröffentlicht in: | Journal of molecular histology 2025-02, Vol.56 (1), p.46, Article 46 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 46 |
| container_title | Journal of molecular histology |
| container_volume | 56 |
| creator | Gomes, Judielson Ribeiro de Moraes, Marcus Vinícius Silva, Flávio Santos da da Silva, Isadora Luísa Gomes de Araújo Júnior, Raimundo Fernandes de Paula Medeiros, Karina Paula Abreu, Bento João da Silva Farias, Naisandra Silva |
| description | Diabetic nephropathy (DN) is one of the most relevant and prevalent microvascular complications associated with Diabetes Mellitus. In recent years, hyperbaric oxygen therapy (HBO) has been used to mitigate tissue damage caused by hypoxia, thereby attenuating inflammatory processes. This study aimed to explore morphological aspects associated with DN in rats subjected to HBO. Forty-eight Wistar rats were divided into the following groups: C (normoglycemic animals),
n
= 12; C + HBO (normoglycemic animals submitted to HBO),
n
= 12; D (diabetic animals)
n
= 12; D + HBO (diabetic animals submitted to HBO),
n
= 12. The C + HBO and D + HBO groups were daily treated with HBO at 2.5 atmospheres absolute pressure (ATA) for 60 min, 5 days a week, for 5 weeks. Kidneys were collected for assessment of structural changes in the tissue parenchyma, assessment of renal fibrosis and renal protein expression of tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1). Our results showed that group D had hyperglycemia and weight loss, and that there was also an increase in the renal corpuscle, Bowman’s space, and distal tubular epithelium, as well as accumulation of collagen. HBO administration effectively prevented glomerular hypertrophy and attenuated the expression of TNF-α and TGF-β1. It also positively affected renal tubules, inhibiting the development of tubular atrophy. These findings suggest that HBO was effective in attenuating the initial alterations observed in DN.
Graphical Abstract |
| doi_str_mv | 10.1007/s10735-024-10330-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3147130295</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3147130295</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2071-a315e72720ba501c246ef62e7e7a75ae709aa5b7639c7d31e006e998338da8673</originalsourceid><addsrcrecordid>eNp9kc1O3TAQRq2qVaHAC3SBLHXTTWBs39jxEiF-KiGxoWtrkswF01wn2Akifaw-SJ-phlCQWLCyNT7fN5YOY18FHAgAc5gEGFUWIFeFAKWgEB_Ytii1KaSqzMeXu7Fb7EtKtwCy0iv7mW0pq20JCrbZ7_N5oFhj9A3vH-ZrCny8oYjDzIdI9xTGxGnwedZ57DiOsR9uZu4Db30a82Sc6qmjxDG0_OrstPj7R_D-niI95HxKvg8LjDWNeUfEkf_ybaA57bJPa-wS7T2fO-zn6cnV8XlxcXn24_joomgkGFGgEiUZaSTUWIJo5ErTWksyZNCUSAYsYlkbrWxjWiUIQJO1lVJVi5U2aod9X3qH2N9NlEa38amhrsNA_ZScEisjFEhbZvTbG_S2n2LIv3uktNa5W2ZKLlQT-5Qird0Q_Qbj7AS4RzNuMeOyGfdkxokc2n-unuoNtS-R_yoyoBYg5adwTfF19zu1_wCiwpou</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3146660062</pqid></control><display><type>article</type><title>Hyperbaric oxygen therapy prevents epithelial atrophy in distal tubules and TGF-β1 overexpression in diabetic rat kidneys</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Gomes, Judielson Ribeiro ; de Moraes, Marcus Vinícius ; Silva, Flávio Santos da ; da Silva, Isadora Luísa Gomes ; de Araújo Júnior, Raimundo Fernandes ; de Paula Medeiros, Karina Paula ; Abreu, Bento João ; da Silva Farias, Naisandra Silva</creator><creatorcontrib>Gomes, Judielson Ribeiro ; de Moraes, Marcus Vinícius ; Silva, Flávio Santos da ; da Silva, Isadora Luísa Gomes ; de Araújo Júnior, Raimundo Fernandes ; de Paula Medeiros, Karina Paula ; Abreu, Bento João ; da Silva Farias, Naisandra Silva</creatorcontrib><description>Diabetic nephropathy (DN) is one of the most relevant and prevalent microvascular complications associated with Diabetes Mellitus. In recent years, hyperbaric oxygen therapy (HBO) has been used to mitigate tissue damage caused by hypoxia, thereby attenuating inflammatory processes. This study aimed to explore morphological aspects associated with DN in rats subjected to HBO. Forty-eight Wistar rats were divided into the following groups: C (normoglycemic animals),
n
= 12; C + HBO (normoglycemic animals submitted to HBO),
n
= 12; D (diabetic animals)
n
= 12; D + HBO (diabetic animals submitted to HBO),
n
= 12. The C + HBO and D + HBO groups were daily treated with HBO at 2.5 atmospheres absolute pressure (ATA) for 60 min, 5 days a week, for 5 weeks. Kidneys were collected for assessment of structural changes in the tissue parenchyma, assessment of renal fibrosis and renal protein expression of tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1). Our results showed that group D had hyperglycemia and weight loss, and that there was also an increase in the renal corpuscle, Bowman’s space, and distal tubular epithelium, as well as accumulation of collagen. HBO administration effectively prevented glomerular hypertrophy and attenuated the expression of TNF-α and TGF-β1. It also positively affected renal tubules, inhibiting the development of tubular atrophy. These findings suggest that HBO was effective in attenuating the initial alterations observed in DN.
Graphical Abstract</description><identifier>ISSN: 1567-2379</identifier><identifier>ISSN: 1567-2387</identifier><identifier>EISSN: 1567-2387</identifier><identifier>DOI: 10.1007/s10735-024-10330-1</identifier><identifier>PMID: 39695030</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animals ; Atrophy ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Developmental Biology ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - therapy ; Diabetic Nephropathies - metabolism ; Diabetic Nephropathies - pathology ; Diabetic Nephropathies - therapy ; Distal tubules ; Epithelium ; Fibrosis ; Hyperbaric oxygen therapy ; Hyperbaric Oxygenation - methods ; Hyperglycemia ; Hypertrophy ; Hypoxia ; Kidney - metabolism ; Kidney - pathology ; Kidney Tubules - metabolism ; Kidney Tubules - pathology ; Kidneys ; Life Sciences ; Male ; Microvasculature ; Nephropathy ; Original Paper ; Oxygen therapy ; Parenchyma ; Rats ; Rats, Wistar ; Renal tubules ; Transforming Growth Factor beta1 - metabolism ; Transforming growth factor-a ; Transforming growth factor-b1 ; Tumor Necrosis Factor-alpha - metabolism ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Journal of molecular histology, 2025-02, Vol.56 (1), p.46, Article 46</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2024 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature B.V.</rights><rights>Copyright Springer Nature B.V. Feb 2025</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2071-a315e72720ba501c246ef62e7e7a75ae709aa5b7639c7d31e006e998338da8673</cites><orcidid>0000-0001-7567-0605 ; 0000-0002-7817-3433 ; 0009-0009-8422-6712 ; 0000-0002-7784-0740 ; 0000-0001-8010-806X ; 0000-0003-0828-109X ; 0000-0002-7019-0482</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10735-024-10330-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10735-024-10330-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39695030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gomes, Judielson Ribeiro</creatorcontrib><creatorcontrib>de Moraes, Marcus Vinícius</creatorcontrib><creatorcontrib>Silva, Flávio Santos da</creatorcontrib><creatorcontrib>da Silva, Isadora Luísa Gomes</creatorcontrib><creatorcontrib>de Araújo Júnior, Raimundo Fernandes</creatorcontrib><creatorcontrib>de Paula Medeiros, Karina Paula</creatorcontrib><creatorcontrib>Abreu, Bento João</creatorcontrib><creatorcontrib>da Silva Farias, Naisandra Silva</creatorcontrib><title>Hyperbaric oxygen therapy prevents epithelial atrophy in distal tubules and TGF-β1 overexpression in diabetic rat kidneys</title><title>Journal of molecular histology</title><addtitle>J Mol Histol</addtitle><addtitle>J Mol Histol</addtitle><description>Diabetic nephropathy (DN) is one of the most relevant and prevalent microvascular complications associated with Diabetes Mellitus. In recent years, hyperbaric oxygen therapy (HBO) has been used to mitigate tissue damage caused by hypoxia, thereby attenuating inflammatory processes. This study aimed to explore morphological aspects associated with DN in rats subjected to HBO. Forty-eight Wistar rats were divided into the following groups: C (normoglycemic animals),
n
= 12; C + HBO (normoglycemic animals submitted to HBO),
n
= 12; D (diabetic animals)
n
= 12; D + HBO (diabetic animals submitted to HBO),
n
= 12. The C + HBO and D + HBO groups were daily treated with HBO at 2.5 atmospheres absolute pressure (ATA) for 60 min, 5 days a week, for 5 weeks. Kidneys were collected for assessment of structural changes in the tissue parenchyma, assessment of renal fibrosis and renal protein expression of tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1). Our results showed that group D had hyperglycemia and weight loss, and that there was also an increase in the renal corpuscle, Bowman’s space, and distal tubular epithelium, as well as accumulation of collagen. HBO administration effectively prevented glomerular hypertrophy and attenuated the expression of TNF-α and TGF-β1. It also positively affected renal tubules, inhibiting the development of tubular atrophy. These findings suggest that HBO was effective in attenuating the initial alterations observed in DN.
Graphical Abstract</description><subject>Animals</subject><subject>Atrophy</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Developmental Biology</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Experimental - therapy</subject><subject>Diabetic Nephropathies - metabolism</subject><subject>Diabetic Nephropathies - pathology</subject><subject>Diabetic Nephropathies - therapy</subject><subject>Distal tubules</subject><subject>Epithelium</subject><subject>Fibrosis</subject><subject>Hyperbaric oxygen therapy</subject><subject>Hyperbaric Oxygenation - methods</subject><subject>Hyperglycemia</subject><subject>Hypertrophy</subject><subject>Hypoxia</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidney Tubules - metabolism</subject><subject>Kidney Tubules - pathology</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Microvasculature</subject><subject>Nephropathy</subject><subject>Original Paper</subject><subject>Oxygen therapy</subject><subject>Parenchyma</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Renal tubules</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><subject>Transforming growth factor-a</subject><subject>Transforming growth factor-b1</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><issn>1567-2379</issn><issn>1567-2387</issn><issn>1567-2387</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1O3TAQRq2qVaHAC3SBLHXTTWBs39jxEiF-KiGxoWtrkswF01wn2Akifaw-SJ-phlCQWLCyNT7fN5YOY18FHAgAc5gEGFUWIFeFAKWgEB_Ytii1KaSqzMeXu7Fb7EtKtwCy0iv7mW0pq20JCrbZ7_N5oFhj9A3vH-ZrCny8oYjDzIdI9xTGxGnwedZ57DiOsR9uZu4Db30a82Sc6qmjxDG0_OrstPj7R_D-niI95HxKvg8LjDWNeUfEkf_ybaA57bJPa-wS7T2fO-zn6cnV8XlxcXn24_joomgkGFGgEiUZaSTUWIJo5ErTWksyZNCUSAYsYlkbrWxjWiUIQJO1lVJVi5U2aod9X3qH2N9NlEa38amhrsNA_ZScEisjFEhbZvTbG_S2n2LIv3uktNa5W2ZKLlQT-5Qird0Q_Qbj7AS4RzNuMeOyGfdkxokc2n-unuoNtS-R_yoyoBYg5adwTfF19zu1_wCiwpou</recordid><startdate>20250201</startdate><enddate>20250201</enddate><creator>Gomes, Judielson Ribeiro</creator><creator>de Moraes, Marcus Vinícius</creator><creator>Silva, Flávio Santos da</creator><creator>da Silva, Isadora Luísa Gomes</creator><creator>de Araújo Júnior, Raimundo Fernandes</creator><creator>de Paula Medeiros, Karina Paula</creator><creator>Abreu, Bento João</creator><creator>da Silva Farias, Naisandra Silva</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7567-0605</orcidid><orcidid>https://orcid.org/0000-0002-7817-3433</orcidid><orcidid>https://orcid.org/0009-0009-8422-6712</orcidid><orcidid>https://orcid.org/0000-0002-7784-0740</orcidid><orcidid>https://orcid.org/0000-0001-8010-806X</orcidid><orcidid>https://orcid.org/0000-0003-0828-109X</orcidid><orcidid>https://orcid.org/0000-0002-7019-0482</orcidid></search><sort><creationdate>20250201</creationdate><title>Hyperbaric oxygen therapy prevents epithelial atrophy in distal tubules and TGF-β1 overexpression in diabetic rat kidneys</title><author>Gomes, Judielson Ribeiro ; de Moraes, Marcus Vinícius ; Silva, Flávio Santos da ; da Silva, Isadora Luísa Gomes ; de Araújo Júnior, Raimundo Fernandes ; de Paula Medeiros, Karina Paula ; Abreu, Bento João ; da Silva Farias, Naisandra Silva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2071-a315e72720ba501c246ef62e7e7a75ae709aa5b7639c7d31e006e998338da8673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Animals</topic><topic>Atrophy</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Developmental Biology</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Experimental - therapy</topic><topic>Diabetic Nephropathies - metabolism</topic><topic>Diabetic Nephropathies - pathology</topic><topic>Diabetic Nephropathies - therapy</topic><topic>Distal tubules</topic><topic>Epithelium</topic><topic>Fibrosis</topic><topic>Hyperbaric oxygen therapy</topic><topic>Hyperbaric Oxygenation - methods</topic><topic>Hyperglycemia</topic><topic>Hypertrophy</topic><topic>Hypoxia</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Kidney Tubules - metabolism</topic><topic>Kidney Tubules - pathology</topic><topic>Kidneys</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Microvasculature</topic><topic>Nephropathy</topic><topic>Original Paper</topic><topic>Oxygen therapy</topic><topic>Parenchyma</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Renal tubules</topic><topic>Transforming Growth Factor beta1 - metabolism</topic><topic>Transforming growth factor-a</topic><topic>Transforming growth factor-b1</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gomes, Judielson Ribeiro</creatorcontrib><creatorcontrib>de Moraes, Marcus Vinícius</creatorcontrib><creatorcontrib>Silva, Flávio Santos da</creatorcontrib><creatorcontrib>da Silva, Isadora Luísa Gomes</creatorcontrib><creatorcontrib>de Araújo Júnior, Raimundo Fernandes</creatorcontrib><creatorcontrib>de Paula Medeiros, Karina Paula</creatorcontrib><creatorcontrib>Abreu, Bento João</creatorcontrib><creatorcontrib>da Silva Farias, Naisandra Silva</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular histology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomes, Judielson Ribeiro</au><au>de Moraes, Marcus Vinícius</au><au>Silva, Flávio Santos da</au><au>da Silva, Isadora Luísa Gomes</au><au>de Araújo Júnior, Raimundo Fernandes</au><au>de Paula Medeiros, Karina Paula</au><au>Abreu, Bento João</au><au>da Silva Farias, Naisandra Silva</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperbaric oxygen therapy prevents epithelial atrophy in distal tubules and TGF-β1 overexpression in diabetic rat kidneys</atitle><jtitle>Journal of molecular histology</jtitle><stitle>J Mol Histol</stitle><addtitle>J Mol Histol</addtitle><date>2025-02-01</date><risdate>2025</risdate><volume>56</volume><issue>1</issue><spage>46</spage><pages>46-</pages><artnum>46</artnum><issn>1567-2379</issn><issn>1567-2387</issn><eissn>1567-2387</eissn><abstract>Diabetic nephropathy (DN) is one of the most relevant and prevalent microvascular complications associated with Diabetes Mellitus. In recent years, hyperbaric oxygen therapy (HBO) has been used to mitigate tissue damage caused by hypoxia, thereby attenuating inflammatory processes. This study aimed to explore morphological aspects associated with DN in rats subjected to HBO. Forty-eight Wistar rats were divided into the following groups: C (normoglycemic animals),
n
= 12; C + HBO (normoglycemic animals submitted to HBO),
n
= 12; D (diabetic animals)
n
= 12; D + HBO (diabetic animals submitted to HBO),
n
= 12. The C + HBO and D + HBO groups were daily treated with HBO at 2.5 atmospheres absolute pressure (ATA) for 60 min, 5 days a week, for 5 weeks. Kidneys were collected for assessment of structural changes in the tissue parenchyma, assessment of renal fibrosis and renal protein expression of tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1). Our results showed that group D had hyperglycemia and weight loss, and that there was also an increase in the renal corpuscle, Bowman’s space, and distal tubular epithelium, as well as accumulation of collagen. HBO administration effectively prevented glomerular hypertrophy and attenuated the expression of TNF-α and TGF-β1. It also positively affected renal tubules, inhibiting the development of tubular atrophy. These findings suggest that HBO was effective in attenuating the initial alterations observed in DN.
Graphical Abstract</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>39695030</pmid><doi>10.1007/s10735-024-10330-1</doi><orcidid>https://orcid.org/0000-0001-7567-0605</orcidid><orcidid>https://orcid.org/0000-0002-7817-3433</orcidid><orcidid>https://orcid.org/0009-0009-8422-6712</orcidid><orcidid>https://orcid.org/0000-0002-7784-0740</orcidid><orcidid>https://orcid.org/0000-0001-8010-806X</orcidid><orcidid>https://orcid.org/0000-0003-0828-109X</orcidid><orcidid>https://orcid.org/0000-0002-7019-0482</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1567-2379 |
| ispartof | Journal of molecular histology, 2025-02, Vol.56 (1), p.46, Article 46 |
| issn | 1567-2379 1567-2387 1567-2387 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3147130295 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Atrophy Biomedical and Life Sciences Biomedicine Cell Biology Developmental Biology Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - therapy Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic Nephropathies - therapy Distal tubules Epithelium Fibrosis Hyperbaric oxygen therapy Hyperbaric Oxygenation - methods Hyperglycemia Hypertrophy Hypoxia Kidney - metabolism Kidney - pathology Kidney Tubules - metabolism Kidney Tubules - pathology Kidneys Life Sciences Male Microvasculature Nephropathy Original Paper Oxygen therapy Parenchyma Rats Rats, Wistar Renal tubules Transforming Growth Factor beta1 - metabolism Transforming growth factor-a Transforming growth factor-b1 Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Hyperbaric oxygen therapy prevents epithelial atrophy in distal tubules and TGF-β1 overexpression in diabetic rat kidneys |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T16%3A00%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hyperbaric%20oxygen%20therapy%20prevents%20epithelial%20atrophy%20in%20distal%20tubules%20and%20TGF-%CE%B21%20overexpression%20in%20diabetic%20rat%20kidneys&rft.jtitle=Journal%20of%20molecular%20histology&rft.au=Gomes,%20Judielson%20Ribeiro&rft.date=2025-02-01&rft.volume=56&rft.issue=1&rft.spage=46&rft.pages=46-&rft.artnum=46&rft.issn=1567-2379&rft.eissn=1567-2387&rft_id=info:doi/10.1007/s10735-024-10330-1&rft_dat=%3Cproquest_cross%3E3147130295%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3146660062&rft_id=info:pmid/39695030&rfr_iscdi=true |