Analysis of Tribological and Cytotoxicity Assays of a Biocompatible Mg–Zn–Ca–Pr Alloy
This work covers a Mg–Zn–Ca–Pr alloy fabricated by a novel method of mechanical alloying and spark plasma sintering (SPS). Currently, magnesium alloys used as biomaterials are mostly commercial alloys without consideration of cytotoxicity from the perspective of biosafety. So far, the tribological a...
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| Veröffentlicht in: | ACS applied materials & interfaces 2025-01, Vol.17 (1), p.269-281 |
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| creator | Lesz, Sabina Popis, Julia Grzegorczyk, Barbara Drygała, Aleksandra Hrapkowicz, Bartłomiej Pakieła, Wojciech Ozimina, Dariusz Lisoń-Kubica, Julia Gołombek, Klaudiusz Garbiec, Dariusz Basiaga, Marcin |
| description | This work covers a Mg–Zn–Ca–Pr alloy fabricated by a novel method of mechanical alloying and spark plasma sintering (SPS). Currently, magnesium alloys used as biomaterials are mostly commercial alloys without consideration of cytotoxicity from the perspective of biosafety. So far, the tribological and cytotoxic properties of Mg–Zn–Ca–Pr alloys have not been investigated. Hence, in the article, the tribological properties, considering wear rate, wear resistance, coefficient of friction, and the roughness of the sintered Mg–Zn–Ca–Pr alloy, are investigated. Cytotoxicity assays have also been carried out. The ball-on-a-disc method is used in the tribological test. Samples before sintering by the SPS method are milled at varying times of 13, 20, and 70 h. Results show that increasing the milling time affects tribology and cytotoxic tests. The longer the milling time, the lower the cell survival rate. The conducted tests reveal cell survival of 90, 82, and 61% for 13, 20, and 70 h, respectively. A reduction of cell viability by over 30% is considered a cytotoxic effect, which was observed only in the 70 h milling-time samples. |
| doi_str_mv | 10.1021/acsami.4c13285 |
| format | Article |
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Currently, magnesium alloys used as biomaterials are mostly commercial alloys without consideration of cytotoxicity from the perspective of biosafety. So far, the tribological and cytotoxic properties of Mg–Zn–Ca–Pr alloys have not been investigated. Hence, in the article, the tribological properties, considering wear rate, wear resistance, coefficient of friction, and the roughness of the sintered Mg–Zn–Ca–Pr alloy, are investigated. Cytotoxicity assays have also been carried out. The ball-on-a-disc method is used in the tribological test. Samples before sintering by the SPS method are milled at varying times of 13, 20, and 70 h. Results show that increasing the milling time affects tribology and cytotoxic tests. The longer the milling time, the lower the cell survival rate. The conducted tests reveal cell survival of 90, 82, and 61% for 13, 20, and 70 h, respectively. A reduction of cell viability by over 30% is considered a cytotoxic effect, which was observed only in the 70 h milling-time samples.</description><identifier>ISSN: 1944-8244</identifier><identifier>ISSN: 1944-8252</identifier><identifier>EISSN: 1944-8252</identifier><identifier>DOI: 10.1021/acsami.4c13285</identifier><identifier>PMID: 39694474</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Alloys - chemistry ; Alloys - pharmacology ; Alloys - toxicity ; Animals ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Biological and Medical Applications of Materials and Interfaces ; Calcium - chemistry ; Cell Line ; Cell Survival - drug effects ; Humans ; Magnesium - chemistry ; Magnesium - toxicity ; Materials Testing ; Mice ; Zinc - chemistry</subject><ispartof>ACS applied materials & interfaces, 2025-01, Vol.17 (1), p.269-281</ispartof><rights>2024 The Authors. 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Mater. Interfaces</addtitle><description>This work covers a Mg–Zn–Ca–Pr alloy fabricated by a novel method of mechanical alloying and spark plasma sintering (SPS). Currently, magnesium alloys used as biomaterials are mostly commercial alloys without consideration of cytotoxicity from the perspective of biosafety. So far, the tribological and cytotoxic properties of Mg–Zn–Ca–Pr alloys have not been investigated. Hence, in the article, the tribological properties, considering wear rate, wear resistance, coefficient of friction, and the roughness of the sintered Mg–Zn–Ca–Pr alloy, are investigated. Cytotoxicity assays have also been carried out. The ball-on-a-disc method is used in the tribological test. Samples before sintering by the SPS method are milled at varying times of 13, 20, and 70 h. Results show that increasing the milling time affects tribology and cytotoxic tests. The longer the milling time, the lower the cell survival rate. The conducted tests reveal cell survival of 90, 82, and 61% for 13, 20, and 70 h, respectively. A reduction of cell viability by over 30% is considered a cytotoxic effect, which was observed only in the 70 h milling-time samples.</description><subject>Alloys - chemistry</subject><subject>Alloys - pharmacology</subject><subject>Alloys - toxicity</subject><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biological and Medical Applications of Materials and Interfaces</subject><subject>Calcium - chemistry</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Humans</subject><subject>Magnesium - chemistry</subject><subject>Magnesium - toxicity</subject><subject>Materials Testing</subject><subject>Mice</subject><subject>Zinc - chemistry</subject><issn>1944-8244</issn><issn>1944-8252</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kT1PwzAQhi0E4qOwMqKMCKnFdpzUnVCp-JKKYCgLDNbZcYqRExc7RWTjP_AP-SUYWioYWM6W7rn3TnoQ2ie4RzAlx6ACVKbHFEkpz9bQNhkw1uU0o-urP2NbaCeEJ4zzlOJsE22lgzy2-mwbPQxrsG0wIXFlMvFGOuumRoFNoC6SUdu4xr0aZZo2GYYA7TcHyalxylUzaIy0Ormefry939exjCCWW58MrXXtLtoowQa9t3w76O78bDK67I5vLq5Gw3EXaJ80XVWQPudlRlLIOadEKSlLxRmBQiosmSy0kjRTOFccdJ6yjGVcyxITVtAcZNpBJ4vc2VxWulC6bjxYMfOmAt8KB0b87dTmUUzdiyBxcZoRHBMOlwnePc91aERlgtLWQq3dPIiUsD6hA54PItpboMq7ELwuV3sIFl9KxEKJWCqJAwe_r1vhPw4icLQA4qB4cnMfjYT_0j4BhJ6big</recordid><startdate>20250108</startdate><enddate>20250108</enddate><creator>Lesz, Sabina</creator><creator>Popis, Julia</creator><creator>Grzegorczyk, Barbara</creator><creator>Drygała, Aleksandra</creator><creator>Hrapkowicz, Bartłomiej</creator><creator>Pakieła, Wojciech</creator><creator>Ozimina, Dariusz</creator><creator>Lisoń-Kubica, Julia</creator><creator>Gołombek, Klaudiusz</creator><creator>Garbiec, Dariusz</creator><creator>Basiaga, Marcin</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3443-6537</orcidid><orcidid>https://orcid.org/0000-0002-2703-2059</orcidid><orcidid>https://orcid.org/0000-0003-2813-7853</orcidid><orcidid>https://orcid.org/0000-0001-5978-3861</orcidid><orcidid>https://orcid.org/0000-0002-8773-5645</orcidid></search><sort><creationdate>20250108</creationdate><title>Analysis of Tribological and Cytotoxicity Assays of a Biocompatible Mg–Zn–Ca–Pr Alloy</title><author>Lesz, Sabina ; Popis, Julia ; Grzegorczyk, Barbara ; Drygała, Aleksandra ; Hrapkowicz, Bartłomiej ; Pakieła, Wojciech ; Ozimina, Dariusz ; Lisoń-Kubica, Julia ; Gołombek, Klaudiusz ; Garbiec, Dariusz ; Basiaga, Marcin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a271t-cd1788f513a68821ccbbfc841adbc0b4bdecb25c06c8ae6345458ebf014d26ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Alloys - chemistry</topic><topic>Alloys - pharmacology</topic><topic>Alloys - toxicity</topic><topic>Animals</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Biological and Medical Applications of Materials and Interfaces</topic><topic>Calcium - chemistry</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Humans</topic><topic>Magnesium - chemistry</topic><topic>Magnesium - toxicity</topic><topic>Materials Testing</topic><topic>Mice</topic><topic>Zinc - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lesz, Sabina</creatorcontrib><creatorcontrib>Popis, Julia</creatorcontrib><creatorcontrib>Grzegorczyk, Barbara</creatorcontrib><creatorcontrib>Drygała, Aleksandra</creatorcontrib><creatorcontrib>Hrapkowicz, Bartłomiej</creatorcontrib><creatorcontrib>Pakieła, Wojciech</creatorcontrib><creatorcontrib>Ozimina, Dariusz</creatorcontrib><creatorcontrib>Lisoń-Kubica, Julia</creatorcontrib><creatorcontrib>Gołombek, Klaudiusz</creatorcontrib><creatorcontrib>Garbiec, Dariusz</creatorcontrib><creatorcontrib>Basiaga, Marcin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lesz, Sabina</au><au>Popis, Julia</au><au>Grzegorczyk, Barbara</au><au>Drygała, Aleksandra</au><au>Hrapkowicz, Bartłomiej</au><au>Pakieła, Wojciech</au><au>Ozimina, Dariusz</au><au>Lisoń-Kubica, Julia</au><au>Gołombek, Klaudiusz</au><au>Garbiec, Dariusz</au><au>Basiaga, Marcin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of Tribological and Cytotoxicity Assays of a Biocompatible Mg–Zn–Ca–Pr Alloy</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. 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Samples before sintering by the SPS method are milled at varying times of 13, 20, and 70 h. Results show that increasing the milling time affects tribology and cytotoxic tests. The longer the milling time, the lower the cell survival rate. The conducted tests reveal cell survival of 90, 82, and 61% for 13, 20, and 70 h, respectively. A reduction of cell viability by over 30% is considered a cytotoxic effect, which was observed only in the 70 h milling-time samples.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>39694474</pmid><doi>10.1021/acsami.4c13285</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-3443-6537</orcidid><orcidid>https://orcid.org/0000-0002-2703-2059</orcidid><orcidid>https://orcid.org/0000-0003-2813-7853</orcidid><orcidid>https://orcid.org/0000-0001-5978-3861</orcidid><orcidid>https://orcid.org/0000-0002-8773-5645</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alloys - chemistry Alloys - pharmacology Alloys - toxicity Animals Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biological and Medical Applications of Materials and Interfaces Calcium - chemistry Cell Line Cell Survival - drug effects Humans Magnesium - chemistry Magnesium - toxicity Materials Testing Mice Zinc - chemistry |
| title | Analysis of Tribological and Cytotoxicity Assays of a Biocompatible Mg–Zn–Ca–Pr Alloy |
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