Computer modeling of bevacizumab drug distribution after intravitreal injection in rabbit and human eyes

Age-related macular degeneration (AMD) is a progressive eye disease that causes loss of central vision and has no cure. Wet AMD is the late neovascular form treated with vascular endothelial growth factor (VEGF) inhibitors. VEGF is the critical driver of wet AMD. One common off-label anti-VEGF drug...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2024-12
Hauptverfasser:	Chowdhury, Jabia M., Chacin Ruiz, Eduardo A., Ohr, Matthew P., Swindle-Reilly, Katelyn E., Ford Versypt, Ashlee N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody drug Distribution Drug transport Dynamic simulation Elimination In silico modeling Mathematical model Mechanistic modeling Pharmacokinetics
Online-Zugang:	Volltext
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