Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy

Tissue inflammation is often broadly associated with cellular damage, yet sterile inflammation also plays critical roles in beneficial tissue remodeling. In the central nervous system, this is observed through a predominantly innate immune response in retinal vascular diseases such as age-related ma...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-12, Vol.121 (52), p.e2411640121
Hauptverfasser:	Hata, Masayuki, Hata, Maki, Dejda, Agnieszka, Pilon, Frédérique, Diaz-Marin, Roberto, Fournier, Frédérik, Joyal, Jean-Sebastien, Cagnone, Gael, Ochi, Yotaro, Crespo-Garcia, Sergio, Wilson, Ariel M, Sapieha, Przemyslaw
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - pharmacology Adrenal Cortex Hormones - therapeutic use Age Age related diseases Angiogenesis Animals Anti-inflammatory agents Blood vessels Central nervous system Chemokine receptors Corticoids Corticosteroids CX3C Chemokine Receptor 1 - genetics CX3C Chemokine Receptor 1 - metabolism Damage Dexamethasone Dexamethasone - pharmacology Diabetes mellitus Disease Models, Animal Eye diseases Homeostasis Immune response Immune system Immunity, Innate - drug effects Immunosuppressive agents Inflammation Inflammation - drug therapy Inflammation - pathology Innate immunity Lysozyme Macular degeneration Mice Mice, Inbred C57BL Microglia Microglia - drug effects Microglia - metabolism Microglia - pathology Muramidase - metabolism Myeloid cells Myeloid Cells - drug effects Myeloid Cells - metabolism Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Oxygen - metabolism Population genetics Regression models Retina - drug effects Retina - metabolism Retina - pathology Retinal Neovascularization - drug therapy Retinal Neovascularization - metabolism Retinal Neovascularization - pathology Retinal Vessels - drug effects Retinal Vessels - metabolism Retinal Vessels - pathology Retinopathy Steroids Vascular diseases Vascular Remodeling - drug effects Vascularization
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