Low-inflammatory lipid nanoparticle-based mRNA vaccine elicits protective immunity against H5N1 influenza virus with reduced adverse reactions

Messenger RNA vaccines based on lipid nanoparticles (mRNA-LNPs) are promising vaccine modalities. However, mRNA-LNP vaccines frequently cause adverse reactions such as swelling and fever in humans, partly due to the inflammatory nature of LNP. Modification of the ionizable lipids used in LNPs is one...

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Veröffentlicht in:	Molecular therapy 2024-12
Hauptverfasser:	Kawai, Atsushi, Shimizu, Taro, Tanaka, Hiroki, Shichinohe, Shintaro, Anindita, Jessica, Hirose, Mika, Kawahara, Eigo, Senpuku, Kota, Shimooka, Makoto, Quynh Mai, Le Thi, Suzuki, Ryo, Nogimori, Takuto, Yamamoto, Takuya, Hirai, Toshiro, Kato, Takayuki, Watanabe, Tokiko, Akita, Hidetaka, Yoshioka, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse reaction cross-protection high-pathogenicity avian influenza virus ionizable lipid lipid nanoparticle mRNA vaccine
Online-Zugang:	Volltext
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