Motor pool selectivity of neuromuscular degeneration in type I spinal muscular atrophy is conserved between human and mouse

Spinal muscular atrophy (SMA) is caused by low levels of the survival motor neuron (SMN) protein. Even though SMN is ubiquitously expressed, the disease selectively affects motor neurons, leading to progressive muscle weakness. Even among motor neurons, certain motor units appear more clinically res...

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Veröffentlicht in:	Human molecular genetics 2024-12
Hauptverfasser:	Lee, Justin C, Chung, Wendy K, Pisapia, David J, Henderson, Christopher E
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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