Procognitive and neurotrophic benefits of α5-GABA-A receptor positive allosteric modulation in a β-amyloid deposition mouse model of Alzheimer’s disease pathology

Reduced somatostatin (SST) and SST-expressing GABAergic neurons are well-replicated findings in Alzheimer’s disease (AD) and are associated with cognitive deficits. SST cells inhibit pyramidal cell dendrites through α5-GABA-A receptors (α5-GABAA-R). α5-GABAAR positive allosteric modulation (α5-PAM)...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Neurobiology of aging 2025-03, Vol.147, p.49-59
Hauptverfasser:	Bernardo, Ashley M., Marcotte, Michael, Wong, Kayla, Sharmin, Dishary, Pandey, Kamal P., Cook, James M., Sibille, Etienne L., Prevot, Thomas D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Cognition GABA Neurotrophic effect Positive allosteric modulator
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!