Blockage of polycystin-2 alleviates myocardial ischemia/reperfusion injury by inhibiting autophagy through the Ca2+/Akt/Beclin 1 pathway

Autophagy is a well-conserved self-protection process that plays an important role in cardiovascular diseases. Excessive autophagy during myocardial ischemia/reperfusion injury (MIRI) induces calcium overload and the overactivation of an autophagic response, thereby aggravating cardiomyocyte damage....

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochimica et biophysica acta. Molecular cell research 2025-02, Vol.1872 (2), p.119892, Article 119892
Hauptverfasser:	Qin, Xiao-dan, Liang, Jian-feng, Gan, Lin-yu, Peng, Ke-shan, Huang, Xue-hong, Li, Xiao-ting, Chen, Jin-li, Li, Wan, Zhang, Lei, Jian, Jie, Lu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Calcium Cardiovascular disease Myocardial ischemia/reperfusion injury Polycystin-2
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!