The Voltage-Gated Potassium Channel Shal (K v 4) Contributes to Active Hearing in Drosophila
The full complement of ion channels which influence insect auditory mechanotransduction and the mechanisms by which their influence is exerted remain unclear. (K 4), a family member encoding voltage-gated potassium channels in , has been shown to localize to dendrites in some neuron types, suggestin...
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| creator | Gregory, Eli S Xu, YiFeng Y J Lee, Tai-Ting Joiner, Mei-Ling A Kamikouchi, Azusa Su, Matthew P Eberl, Daniel F |
| description | The full complement of ion channels which influence insect auditory mechanotransduction and the mechanisms by which their influence is exerted remain unclear.
(K
4), a
family member encoding voltage-gated potassium channels in
, has been shown to localize to dendrites in some neuron types, suggesting the potential role of
in
hearing, including mechanotransduction. A GFP trap was used to visualize the localization of the
channel in Johnston's organ neurons responsible for hearing in the antenna.
protein was localized strongly to the cell body and inner dendritic segment of sensory neurons. It was also detectable in the sensory cilium, suggesting its involvement not only in general auditory function but specifically in mechanotransduction. Electrophysiological recordings to assess neural responses to auditory stimuli in mutant
flies revealed significant decreases in auditory responses. Laser Doppler vibrometer recordings indicated abnormal antennal free fluctuation frequencies in mutant lines, indicating an effect on active antennal tuning, and thus active transduction mechanisms. This suggests that
participates in coordinating energy-dependent antennal movements in
that are essential for tuning the antenna to courtship song frequencies. |
| doi_str_mv | 10.1523/ENEURO.0083-24.2024 |
| format | Article |
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(K
4), a
family member encoding voltage-gated potassium channels in
, has been shown to localize to dendrites in some neuron types, suggesting the potential role of
in
hearing, including mechanotransduction. A GFP trap was used to visualize the localization of the
channel in Johnston's organ neurons responsible for hearing in the antenna.
protein was localized strongly to the cell body and inner dendritic segment of sensory neurons. It was also detectable in the sensory cilium, suggesting its involvement not only in general auditory function but specifically in mechanotransduction. Electrophysiological recordings to assess neural responses to auditory stimuli in mutant
flies revealed significant decreases in auditory responses. Laser Doppler vibrometer recordings indicated abnormal antennal free fluctuation frequencies in mutant lines, indicating an effect on active antennal tuning, and thus active transduction mechanisms. This suggests that
participates in coordinating energy-dependent antennal movements in
that are essential for tuning the antenna to courtship song frequencies.</description><identifier>ISSN: 2373-2822</identifier><identifier>EISSN: 2373-2822</identifier><identifier>DOI: 10.1523/ENEURO.0083-24.2024</identifier><identifier>PMID: 39689967</identifier><language>eng</language><publisher>United States: Society for Neuroscience</publisher><subject>Acoustic Stimulation ; Animals ; Animals, Genetically Modified ; Arthropod Antennae - physiology ; Drosophila melanogaster - physiology ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Female ; Hearing - physiology ; Male ; Mechanotransduction, Cellular - physiology ; Mutation ; New Research ; Sensory Receptor Cells - metabolism ; Sensory Receptor Cells - physiology ; Shal Potassium Channels - genetics ; Shal Potassium Channels - metabolism</subject><ispartof>eNeuro, 2025-01, Vol.12 (1), p.ENEURO.0083-24.2024</ispartof><rights>Copyright © 2025 Gregory et al.</rights><rights>Copyright © 2025 Gregory et al. 2025</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1564-addb87e67ac56f7bd22f6c5caa31266f043d66002465822f99f75a67ee0bcfff3</cites><orcidid>0000-0002-0550-0050 ; 0000-0002-6186-211X ; 0000-0003-1552-6892 ; 0000-0002-4109-4678 ; 0009-0008-5032-7147 ; 0000-0001-9982-9895 ; 0000-0002-7775-7349</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728854/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728854/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39689967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gregory, Eli S</creatorcontrib><creatorcontrib>Xu, YiFeng Y J</creatorcontrib><creatorcontrib>Lee, Tai-Ting</creatorcontrib><creatorcontrib>Joiner, Mei-Ling A</creatorcontrib><creatorcontrib>Kamikouchi, Azusa</creatorcontrib><creatorcontrib>Su, Matthew P</creatorcontrib><creatorcontrib>Eberl, Daniel F</creatorcontrib><title>The Voltage-Gated Potassium Channel Shal (K v 4) Contributes to Active Hearing in Drosophila</title><title>eNeuro</title><addtitle>eNeuro</addtitle><description>The full complement of ion channels which influence insect auditory mechanotransduction and the mechanisms by which their influence is exerted remain unclear.
(K
4), a
family member encoding voltage-gated potassium channels in
, has been shown to localize to dendrites in some neuron types, suggesting the potential role of
in
hearing, including mechanotransduction. A GFP trap was used to visualize the localization of the
channel in Johnston's organ neurons responsible for hearing in the antenna.
protein was localized strongly to the cell body and inner dendritic segment of sensory neurons. It was also detectable in the sensory cilium, suggesting its involvement not only in general auditory function but specifically in mechanotransduction. Electrophysiological recordings to assess neural responses to auditory stimuli in mutant
flies revealed significant decreases in auditory responses. Laser Doppler vibrometer recordings indicated abnormal antennal free fluctuation frequencies in mutant lines, indicating an effect on active antennal tuning, and thus active transduction mechanisms. This suggests that
participates in coordinating energy-dependent antennal movements in
that are essential for tuning the antenna to courtship song frequencies.</description><subject>Acoustic Stimulation</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Arthropod Antennae - physiology</subject><subject>Drosophila melanogaster - physiology</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Female</subject><subject>Hearing - physiology</subject><subject>Male</subject><subject>Mechanotransduction, Cellular - physiology</subject><subject>Mutation</subject><subject>New Research</subject><subject>Sensory Receptor Cells - metabolism</subject><subject>Sensory Receptor Cells - physiology</subject><subject>Shal Potassium Channels - genetics</subject><subject>Shal Potassium Channels - metabolism</subject><issn>2373-2822</issn><issn>2373-2822</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1P3DAQhi1EBYjyCyohH-GQrb9iJyeEtgtURYBa6AnJmjjjjVE23sbJSvz7ZrUU0dPMaGbemVcPIV84m_FcyK-Lu8XTz_sZY4XMhJoJJtQeORLSTGUhxP6H_JCcpPTCGONaGF7wA3IoS12UpTZH5PmxQfo7tgMsMbuGAWv6EAdIKYwrOm-g67Clvxpo6dkPuqHqnM5jN_ShGgdMdIj00g1hg_QGoQ_dkoaOfutjiusmtPCZfPLQJjx5i8fk6WrxOL_Jbu-vv88vbzPHc60yqOuqMKgNuFx7U9VCeO1yByC50NozJWut2WRR55MfX5be5KANIquc914ek4ud7nqsVlg7nD6E1q77sIL-1UYI9v9OFxq7jBvLuRFFkatJ4exNoY9_RkyDXYXksG2hwzgmK7nSpSq4kdOo3I26yWfq0b_f4cxu2dgdG7tlY4WyWzbT1unHF993_pGQfwEXuYrU</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Gregory, Eli S</creator><creator>Xu, YiFeng Y J</creator><creator>Lee, Tai-Ting</creator><creator>Joiner, Mei-Ling A</creator><creator>Kamikouchi, Azusa</creator><creator>Su, Matthew P</creator><creator>Eberl, Daniel F</creator><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0550-0050</orcidid><orcidid>https://orcid.org/0000-0002-6186-211X</orcidid><orcidid>https://orcid.org/0000-0003-1552-6892</orcidid><orcidid>https://orcid.org/0000-0002-4109-4678</orcidid><orcidid>https://orcid.org/0009-0008-5032-7147</orcidid><orcidid>https://orcid.org/0000-0001-9982-9895</orcidid><orcidid>https://orcid.org/0000-0002-7775-7349</orcidid></search><sort><creationdate>202501</creationdate><title>The Voltage-Gated Potassium Channel Shal (K v 4) Contributes to Active Hearing in Drosophila</title><author>Gregory, Eli S ; 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(K
4), a
family member encoding voltage-gated potassium channels in
, has been shown to localize to dendrites in some neuron types, suggesting the potential role of
in
hearing, including mechanotransduction. A GFP trap was used to visualize the localization of the
channel in Johnston's organ neurons responsible for hearing in the antenna.
protein was localized strongly to the cell body and inner dendritic segment of sensory neurons. It was also detectable in the sensory cilium, suggesting its involvement not only in general auditory function but specifically in mechanotransduction. Electrophysiological recordings to assess neural responses to auditory stimuli in mutant
flies revealed significant decreases in auditory responses. Laser Doppler vibrometer recordings indicated abnormal antennal free fluctuation frequencies in mutant lines, indicating an effect on active antennal tuning, and thus active transduction mechanisms. This suggests that
participates in coordinating energy-dependent antennal movements in
that are essential for tuning the antenna to courtship song frequencies.</abstract><cop>United States</cop><pub>Society for Neuroscience</pub><pmid>39689967</pmid><doi>10.1523/ENEURO.0083-24.2024</doi><orcidid>https://orcid.org/0000-0002-0550-0050</orcidid><orcidid>https://orcid.org/0000-0002-6186-211X</orcidid><orcidid>https://orcid.org/0000-0003-1552-6892</orcidid><orcidid>https://orcid.org/0000-0002-4109-4678</orcidid><orcidid>https://orcid.org/0009-0008-5032-7147</orcidid><orcidid>https://orcid.org/0000-0001-9982-9895</orcidid><orcidid>https://orcid.org/0000-0002-7775-7349</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acoustic Stimulation Animals Animals, Genetically Modified Arthropod Antennae - physiology Drosophila melanogaster - physiology Drosophila Proteins - genetics Drosophila Proteins - metabolism Female Hearing - physiology Male Mechanotransduction, Cellular - physiology Mutation New Research Sensory Receptor Cells - metabolism Sensory Receptor Cells - physiology Shal Potassium Channels - genetics Shal Potassium Channels - metabolism |
| title | The Voltage-Gated Potassium Channel Shal (K v 4) Contributes to Active Hearing in Drosophila |
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