Implications of the choroid plexus in Niemann-Pick disease Type C neuropathogenesis

•Choroid plexus enlargement was observed in patients with NPC.•Choroid plexus enlargement was associated with the severity of neurodegeneration, neuropsychiatric symptoms, and circulatory markers.•Choroid plexus and thalamic volumes have predictive power to differentiate patients with NPC from other...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2025-02, Vol.124, p.376-384
Hauptverfasser:	van Gool, Raquel, Cay, Mariesa, Ren, Boyu, Brodeur, Kailey, Golden, Emma, Goodlett, Benjamin, Yang, Edward, Reilly, Tom, Hastings, Caroline, Berry-Kravis, Elizabeth M., Lee, Pui Y., Di Biase, Maria, Cropley, Vanessa, Pantelis, Christos, Velakoulis, Dennis, Shinn, Ann K., Al-Hertani, Walla, Walterfang, Mark, Upadhyay, Jaymin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biomarkers Bipolar Disorder Bipolar Disorder - metabolism Bipolar Disorder - pathology Blood Plasma Choroid Plexus Choroid Plexus - metabolism Choroid Plexus - pathology Female Humans Magnetic Resonance Imaging Magnetic Resonance Imaging - methods Male Middle Aged Neuroimaging - methods Neuropsychiatric Symptoms Niemann Pick Disease Type C Niemann-Pick Disease, Type C - metabolism Niemann-Pick Disease, Type C - pathology Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - metabolism Schizophrenia - pathology Thalamus Young Adult
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