Pivotal Role of the Intracellular Microenvironment in the High Photodynamic Activity of Cationic Phthalocyanines

To investigate the influence of phthalocyanine aggregation on their photodynamic activity, a series of six cationic water-soluble zinc(II) phthalocyanines bearing from four to sixteen 4-((diethylmethylammonium)methyl)phenoxy substituents was synthesized. Depending on their structure, the phthaloc...

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Veröffentlicht in:	Journal of medicinal chemistry 2025-01, Vol.68 (1), p.658-673
Hauptverfasser:	Bunin, Dmitry A., Akasov, Roman A., Martynov, Alexander G., Stepanova, Maria P., Monich, Svetlana V., Tsivadze, Aslan Yu, Gorbunova, Yulia G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cations - chemistry Cell Line, Tumor Humans Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Isoindoles - chemistry Isoindoles - pharmacology MCF-7 Cells Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Photochemotherapy Photosensitizing Agents - chemical synthesis Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Structure-Activity Relationship
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