Associations of sarcopenia and malnutrition with 30-day in-hospital morbidity and mortality after cardiac surgery
Sarcopenia and malnutrition often occur simultaneously in adults with cardiovascular diseases. Our objective was to determine the associations of preoperative sarcopenia and malnutrition with major adverse cardiac and cerebral events (MACCE) after cardiac surgery. We retrospectively analysed 154 con...
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| Veröffentlicht in: | European journal of cardio-thoracic surgery 2024-12, Vol.67 (1) |
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| container_title | European journal of cardio-thoracic surgery |
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| creator | Abe, Takahiro Inao, Tasuku Shingu, Yasushige Yamada, Akira Takada, Shingo Fukushima, Arata Oyama-Manabe, Noriko Yokota, Isao Wakasa, Satoru Kinugawa, Shintaro Yokota, Takashi |
| description | Sarcopenia and malnutrition often occur simultaneously in adults with cardiovascular diseases. Our objective was to determine the associations of preoperative sarcopenia and malnutrition with major adverse cardiac and cerebral events (MACCE) after cardiac surgery.
We retrospectively analysed 154 consecutive patients who underwent elective cardiac surgery between January 2015 and June 2018 at two institutions in Japan. Sarcopenia and nutritional status were preoperatively assessed by bilateral psoas muscle volume index (PMVI) using CT scans and the prognostic nutritional index (PNI), respectively.
The median age in the total cohort was 69 years, and 43% were women. Within 30 days after surgery, 20 patients developed in-hospital MACCE and seven patients died of any cause. Low PMVI ( |
| doi_str_mv | 10.1093/ejcts/ezae456 |
| format | Article |
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We retrospectively analysed 154 consecutive patients who underwent elective cardiac surgery between January 2015 and June 2018 at two institutions in Japan. Sarcopenia and nutritional status were preoperatively assessed by bilateral psoas muscle volume index (PMVI) using CT scans and the prognostic nutritional index (PNI), respectively.
The median age in the total cohort was 69 years, and 43% were women. Within 30 days after surgery, 20 patients developed in-hospital MACCE and seven patients died of any cause. Low PMVI (<72.25 cm3/m2) and low PNI (<48.15) were each independent predictors of postoperative MACCE occurrence with odds ratios (95% confidence interval) of 3.58 (1.22-10.53) and 3.73 (1.25-11.09) when adjusted for age and sex, and 3.25 (1.07-9.87) and 3.27 (1.08-9.89) when adjusted for preoperative left ventricular ejection fraction, angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker, and anticoagulant. In addition, the combination of low PMVI and low PNI conferred the highest risk of in-hospital MACCE among the four groups (i.e. the low PMVI, low PNI, low PMVI + low PNI and neither low PMVI nor low PNI groups).
Preoperative low PMVI and low PNI were respectively associated with 30-day in-hospital MACCE occurrence after cardiac surgery. Notably, coexistence of these reductions further enhanced the risk of postoperative MACCE.</description><identifier>ISSN: 1010-7940</identifier><identifier>ISSN: 1873-734X</identifier><identifier>EISSN: 1873-734X</identifier><identifier>DOI: 10.1093/ejcts/ezae456</identifier><identifier>PMID: 39689034</identifier><language>eng</language><publisher>Germany</publisher><subject>Aged ; Cardiac Surgical Procedures - adverse effects ; Cardiac Surgical Procedures - mortality ; Female ; Hospital Mortality ; Humans ; Japan - epidemiology ; Male ; Malnutrition - complications ; Malnutrition - epidemiology ; Malnutrition - mortality ; Middle Aged ; Nutritional Status ; Postoperative Complications - epidemiology ; Postoperative Complications - mortality ; Retrospective Studies ; Risk Factors ; Sarcopenia - complications ; Sarcopenia - epidemiology ; Sarcopenia - mortality</subject><ispartof>European journal of cardio-thoracic surgery, 2024-12, Vol.67 (1)</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c179t-9c26fb474d59b4ecc658d9601ce846e85e36518978467faf4337284453e26b1a3</cites><orcidid>0000-0001-5470-6648 ; 0000-0002-3587-1629 ; 0000-0003-2559-0054 ; 0000-0002-0394-0095 ; 0000-0002-2141-8145 ; 0000-0001-8471-5166 ; 0000-0002-4149-2799 ; 0000-0001-6254-2225 ; 0000-0002-7781-9482</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39689034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abe, Takahiro</creatorcontrib><creatorcontrib>Inao, Tasuku</creatorcontrib><creatorcontrib>Shingu, Yasushige</creatorcontrib><creatorcontrib>Yamada, Akira</creatorcontrib><creatorcontrib>Takada, Shingo</creatorcontrib><creatorcontrib>Fukushima, Arata</creatorcontrib><creatorcontrib>Oyama-Manabe, Noriko</creatorcontrib><creatorcontrib>Yokota, Isao</creatorcontrib><creatorcontrib>Wakasa, Satoru</creatorcontrib><creatorcontrib>Kinugawa, Shintaro</creatorcontrib><creatorcontrib>Yokota, Takashi</creatorcontrib><title>Associations of sarcopenia and malnutrition with 30-day in-hospital morbidity and mortality after cardiac surgery</title><title>European journal of cardio-thoracic surgery</title><addtitle>Eur J Cardiothorac Surg</addtitle><description>Sarcopenia and malnutrition often occur simultaneously in adults with cardiovascular diseases. Our objective was to determine the associations of preoperative sarcopenia and malnutrition with major adverse cardiac and cerebral events (MACCE) after cardiac surgery.
We retrospectively analysed 154 consecutive patients who underwent elective cardiac surgery between January 2015 and June 2018 at two institutions in Japan. Sarcopenia and nutritional status were preoperatively assessed by bilateral psoas muscle volume index (PMVI) using CT scans and the prognostic nutritional index (PNI), respectively.
The median age in the total cohort was 69 years, and 43% were women. Within 30 days after surgery, 20 patients developed in-hospital MACCE and seven patients died of any cause. Low PMVI (<72.25 cm3/m2) and low PNI (<48.15) were each independent predictors of postoperative MACCE occurrence with odds ratios (95% confidence interval) of 3.58 (1.22-10.53) and 3.73 (1.25-11.09) when adjusted for age and sex, and 3.25 (1.07-9.87) and 3.27 (1.08-9.89) when adjusted for preoperative left ventricular ejection fraction, angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker, and anticoagulant. In addition, the combination of low PMVI and low PNI conferred the highest risk of in-hospital MACCE among the four groups (i.e. the low PMVI, low PNI, low PMVI + low PNI and neither low PMVI nor low PNI groups).
Preoperative low PMVI and low PNI were respectively associated with 30-day in-hospital MACCE occurrence after cardiac surgery. Notably, coexistence of these reductions further enhanced the risk of postoperative MACCE.</description><subject>Aged</subject><subject>Cardiac Surgical Procedures - adverse effects</subject><subject>Cardiac Surgical Procedures - mortality</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Malnutrition - complications</subject><subject>Malnutrition - epidemiology</subject><subject>Malnutrition - mortality</subject><subject>Middle Aged</subject><subject>Nutritional Status</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - mortality</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sarcopenia - complications</subject><subject>Sarcopenia - epidemiology</subject><subject>Sarcopenia - mortality</subject><issn>1010-7940</issn><issn>1873-734X</issn><issn>1873-734X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kL1PwzAQxS0EoqUwsiKPLKF27NjxWFV8SZVYQGKLHOdCXSVxaztC4a8n_YDp7t2994YfQreUPFCi2Bw2JoY5_GjgmThDU5pLlkjGP8_HnVCSSMXJBF2FsCGECJbKSzRhSuSKMD5Fu0UIzlgdresCdjUO2hu3hc5qrLsKt7rp-ujt_o-_bVxjRpJKD9h2ydqFrY26wa3zpa1sHI4R58fjQdURPDbaV1YbHHr_BX64Rhe1bgLcnOYMfTw9vi9fktXb8-tysUoMlSomyqSiLrnkVaZKDsaILK-UINRAzgXkGTCR0VzJUcla15wxmeacZwxSUVLNZuj-2Lv1btdDiEVrg4Gm0R24PhSMcqHGlKKjNTlajXcheKiLrbet9kNBSbGnXBwoFyfKo__uVN2XLVT_7j-s7BcET3v6</recordid><startdate>20241226</startdate><enddate>20241226</enddate><creator>Abe, Takahiro</creator><creator>Inao, Tasuku</creator><creator>Shingu, Yasushige</creator><creator>Yamada, Akira</creator><creator>Takada, Shingo</creator><creator>Fukushima, Arata</creator><creator>Oyama-Manabe, Noriko</creator><creator>Yokota, Isao</creator><creator>Wakasa, Satoru</creator><creator>Kinugawa, Shintaro</creator><creator>Yokota, Takashi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5470-6648</orcidid><orcidid>https://orcid.org/0000-0002-3587-1629</orcidid><orcidid>https://orcid.org/0000-0003-2559-0054</orcidid><orcidid>https://orcid.org/0000-0002-0394-0095</orcidid><orcidid>https://orcid.org/0000-0002-2141-8145</orcidid><orcidid>https://orcid.org/0000-0001-8471-5166</orcidid><orcidid>https://orcid.org/0000-0002-4149-2799</orcidid><orcidid>https://orcid.org/0000-0001-6254-2225</orcidid><orcidid>https://orcid.org/0000-0002-7781-9482</orcidid></search><sort><creationdate>20241226</creationdate><title>Associations of sarcopenia and malnutrition with 30-day in-hospital morbidity and mortality after cardiac surgery</title><author>Abe, Takahiro ; Inao, Tasuku ; Shingu, Yasushige ; Yamada, Akira ; Takada, Shingo ; Fukushima, Arata ; Oyama-Manabe, Noriko ; Yokota, Isao ; Wakasa, Satoru ; Kinugawa, Shintaro ; Yokota, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c179t-9c26fb474d59b4ecc658d9601ce846e85e36518978467faf4337284453e26b1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Cardiac Surgical Procedures - adverse effects</topic><topic>Cardiac Surgical Procedures - mortality</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Malnutrition - complications</topic><topic>Malnutrition - epidemiology</topic><topic>Malnutrition - mortality</topic><topic>Middle Aged</topic><topic>Nutritional Status</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - mortality</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sarcopenia - complications</topic><topic>Sarcopenia - epidemiology</topic><topic>Sarcopenia - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abe, Takahiro</creatorcontrib><creatorcontrib>Inao, Tasuku</creatorcontrib><creatorcontrib>Shingu, Yasushige</creatorcontrib><creatorcontrib>Yamada, Akira</creatorcontrib><creatorcontrib>Takada, Shingo</creatorcontrib><creatorcontrib>Fukushima, Arata</creatorcontrib><creatorcontrib>Oyama-Manabe, Noriko</creatorcontrib><creatorcontrib>Yokota, Isao</creatorcontrib><creatorcontrib>Wakasa, Satoru</creatorcontrib><creatorcontrib>Kinugawa, Shintaro</creatorcontrib><creatorcontrib>Yokota, Takashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cardio-thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abe, Takahiro</au><au>Inao, Tasuku</au><au>Shingu, Yasushige</au><au>Yamada, Akira</au><au>Takada, Shingo</au><au>Fukushima, Arata</au><au>Oyama-Manabe, Noriko</au><au>Yokota, Isao</au><au>Wakasa, Satoru</au><au>Kinugawa, Shintaro</au><au>Yokota, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of sarcopenia and malnutrition with 30-day in-hospital morbidity and mortality after cardiac surgery</atitle><jtitle>European journal of cardio-thoracic surgery</jtitle><addtitle>Eur J Cardiothorac Surg</addtitle><date>2024-12-26</date><risdate>2024</risdate><volume>67</volume><issue>1</issue><issn>1010-7940</issn><issn>1873-734X</issn><eissn>1873-734X</eissn><abstract>Sarcopenia and malnutrition often occur simultaneously in adults with cardiovascular diseases. Our objective was to determine the associations of preoperative sarcopenia and malnutrition with major adverse cardiac and cerebral events (MACCE) after cardiac surgery.
We retrospectively analysed 154 consecutive patients who underwent elective cardiac surgery between January 2015 and June 2018 at two institutions in Japan. Sarcopenia and nutritional status were preoperatively assessed by bilateral psoas muscle volume index (PMVI) using CT scans and the prognostic nutritional index (PNI), respectively.
The median age in the total cohort was 69 years, and 43% were women. Within 30 days after surgery, 20 patients developed in-hospital MACCE and seven patients died of any cause. Low PMVI (<72.25 cm3/m2) and low PNI (<48.15) were each independent predictors of postoperative MACCE occurrence with odds ratios (95% confidence interval) of 3.58 (1.22-10.53) and 3.73 (1.25-11.09) when adjusted for age and sex, and 3.25 (1.07-9.87) and 3.27 (1.08-9.89) when adjusted for preoperative left ventricular ejection fraction, angiotensin-converting enzyme inhibitor or angiotensin-receptor blocker, and anticoagulant. In addition, the combination of low PMVI and low PNI conferred the highest risk of in-hospital MACCE among the four groups (i.e. the low PMVI, low PNI, low PMVI + low PNI and neither low PMVI nor low PNI groups).
Preoperative low PMVI and low PNI were respectively associated with 30-day in-hospital MACCE occurrence after cardiac surgery. Notably, coexistence of these reductions further enhanced the risk of postoperative MACCE.</abstract><cop>Germany</cop><pmid>39689034</pmid><doi>10.1093/ejcts/ezae456</doi><orcidid>https://orcid.org/0000-0001-5470-6648</orcidid><orcidid>https://orcid.org/0000-0002-3587-1629</orcidid><orcidid>https://orcid.org/0000-0003-2559-0054</orcidid><orcidid>https://orcid.org/0000-0002-0394-0095</orcidid><orcidid>https://orcid.org/0000-0002-2141-8145</orcidid><orcidid>https://orcid.org/0000-0001-8471-5166</orcidid><orcidid>https://orcid.org/0000-0002-4149-2799</orcidid><orcidid>https://orcid.org/0000-0001-6254-2225</orcidid><orcidid>https://orcid.org/0000-0002-7781-9482</orcidid></addata></record> |
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| ispartof | European journal of cardio-thoracic surgery, 2024-12, Vol.67 (1) |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Aged Cardiac Surgical Procedures - adverse effects Cardiac Surgical Procedures - mortality Female Hospital Mortality Humans Japan - epidemiology Male Malnutrition - complications Malnutrition - epidemiology Malnutrition - mortality Middle Aged Nutritional Status Postoperative Complications - epidemiology Postoperative Complications - mortality Retrospective Studies Risk Factors Sarcopenia - complications Sarcopenia - epidemiology Sarcopenia - mortality |
| title | Associations of sarcopenia and malnutrition with 30-day in-hospital morbidity and mortality after cardiac surgery |
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