Peripherally Restricted Activation of Opioid Receptors Influences Anxiety-Related Behaviour and Alters Brain Gene Expression in a Sex-Specific Manner

Although effects of stress-induced anxiety on the gastrointestinal tract and enteric nervous system (ENS) are well studied, how ENS dysfunction impacts behaviour is not well understood. We investigated whether ENS modulation alters anxiety-related behaviour in rats. We used loperamide, a potent μ-op...

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Veröffentlicht in:	International journal of molecular sciences 2024-12, Vol.25 (23), p.13183
Hauptverfasser:	Parkar, Nabil, Young, Wayne, Olson, Trent, Hurst, Charlotte, Janssen, Patrick, Spencer, Nick J, McNabb, Warren C, Dalziel, Julie E
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTH Animals Anxiety Anxiety - metabolism Behavior, Animal - drug effects Brain Brain - drug effects Brain - metabolism Corticotropin releasing hormone Endorphins Enteric Nervous System - metabolism Female Females GABA Gastrointestinal Microbiome - drug effects Gastrointestinal system Gender differences Gene expression Gene Expression Regulation - drug effects Genes Hippocampus - drug effects Hippocampus - metabolism Influence Kinases Loperamide Loperamide - pharmacology Male Microbiota Microbiota (Symbiotic organisms) Motility Narcotics Rats Rats, Sprague-Dawley Receptors, Opioid - genetics Receptors, Opioid - metabolism Sex Characteristics Sex Factors Statistical analysis Stress Stress (Psychology) Velocity
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