Calaspargase-Pegol-Mknl Combined with BCL-2 and MCL-1 Inhibition for Acute Myeloid Leukemia

Our previous studies have demonstrated that pegcrisantaspase (PegC), a long-acting asparaginase, synergizes with the BCL-2 inhibitor Venetoclax (Ven) in vitro and in vivo; however, the anti-leukemic activity of -derived asparaginases in combination with BCL-2 inhibition, and potential synergy with i...

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Veröffentlicht in:	International journal of molecular sciences 2024-12, Vol.25 (23), p.13091
Hauptverfasser:	Bollino, Dominique, Ma, Xinrong, Tighe, Kayla M, Casildo, Andrea, Richard, Katharina, Passaniti, Antonino, Carter-Cooper, Brandon, Strovel, Erin T, Emadi, Ashkan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Apoptosis Apoptosis - drug effects Asparaginase - pharmacology Asparaginase - therapeutic use Bridged Bicyclo Compounds, Heterocyclic Cell cycle Cell death Cell growth Cell Line, Tumor Drug Synergism E coli Escherichia coli Humans Investigations Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Mice Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors Myeloid Cell Leukemia Sequence 1 Protein - metabolism Protein biosynthesis Proteins Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors Proto-Oncogene Proteins c-bcl-2 - metabolism Pyrimidines Sulfonamides Thiophenes Xenograft Model Antitumor Assays
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