Molecular Composition and Kinetics of B Cells During Ibrutinib Treatment in Patients with Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of B cells due to constitutive B-cell receptor (BCR) signaling, leading to apoptosis resistance and increased proliferation. This study evaluates the effects of the Bruton Tyrosine Kinase (BTK) inhibitor ibrutinib on the molecul...

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Veröffentlicht in:	International journal of molecular sciences 2024-12, Vol.25 (23), p.12569
Hauptverfasser:	Veyhe, Sólja Remisdóttir, Cédile, Oriane, Dahlmann, Sara Kamuk, Krejcik, Jakub, Abildgaard, Niels, Høyer, Thor, Møller, Michael Boe, Thomassen, Mads, Juul-Jensen, Karen, Frederiksen, Henrik, Dybkær, Karen, Hansen, Marcus Høy, Nyvold, Charlotte Guldborg
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - therapeutic use Agammaglobulinaemia Tyrosine Kinase - antagonists & inhibitors Agammaglobulinaemia Tyrosine Kinase - genetics Agammaglobulinaemia Tyrosine Kinase - metabolism Aged Aged, 80 and over Apoptosis B cells B-Lymphocytes - drug effects B-Lymphocytes - immunology B-Lymphocytes - metabolism Bridged Bicyclo Compounds, Heterocyclic - pharmacology Bridged Bicyclo Compounds, Heterocyclic - therapeutic use Care and treatment Cells Chronic lymphocytic leukemia Cloning Ethylenediaminetetraacetic acid Exome Sequencing Female Humans Inhibitor drugs Kinases Kinetics Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Lymphocytes Male Medical research Medicine, Experimental Middle Aged Patients Piperidines - pharmacology Piperidines - therapeutic use Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Pyrazoles - pharmacology Pyrazoles - therapeutic use Pyrimidines - pharmacology Pyrimidines - therapeutic use Sulfonamides - pharmacology Sulfonamides - therapeutic use Targeted cancer therapy Tyrosine
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