The Association of Anti-Sm with Osteopontin Related to Cognitive Impairment in a Pristane-Induced Lupus BALB/c Mice Model
The BALB/c model of pristane-induced lupus (PIL) exhibits cognitive impairment features resembling neuropsychiatric lupus (NPLSE). Osteopontin (OPN) is associated with disease activity in SLE; however, its involvement in NPLSE is not yet entirely determined. Our study aims to elucidate the contribut...
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| Veröffentlicht in: | International journal of molecular sciences 2024-12, Vol.25 (23), p.13080 |
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| creator | González-Inostroz, Daniel Sandoval-García, Flavio Corona-Meraz, Fernanda-Isadora Vázquez Del Mercado, Mónica Guzmán-Muñiz, Jorge Guzmán-Ornelas, Milton Omar Castañeda-Arellano, Rolando Bañuelos-Pineda, Jacinto Peña-Nava, Miguel Martín-Márquez, Beatriz-Teresita |
| description | The BALB/c model of pristane-induced lupus (PIL) exhibits cognitive impairment features resembling neuropsychiatric lupus (NPLSE). Osteopontin (OPN) is associated with disease activity in SLE; however, its involvement in NPLSE is not yet entirely determined. Our study aims to elucidate the contribution of full-length OPN (OPN-FL) plasma expression, OPN N-half, and
to cognitive impairment in the PIL mice model. A total of 76 female BALB/c mice were divided into pristane (P), pristane plus lipopolysaccharide (P plus LPS) and control (C) groups. In behavioral tests, the P group showed cognitive and visuospatial memory impairment. Elevated plasma OPN FL levels were found in P compared to C groups (177.7 ± 90.1 vs. 105.9 ± 56.8 ng/mL,
= 0.009) and OPN N-half was different between P and C groups (673.5 ± 144.6 vs. 624.5 ± 377.7 ng/mL,
= 0.028) and P plus LPS and C groups (624.5 ± 377.7 vs. 381.4 ± 205.0 ng/mL,
= 0.001). Anti-Sm correlated with OPN-FL (r = 0.269,
= 0.0150). The relative expression of
in the brain was 2.5 and 2.7-fold higher in P and P plus LPS groups, respectively. The evidence suggests that OPN is related to cognitive impairment in PIL mice and might play a relevant role in the detrimental neurological conditions of NPSLE. |
| doi_str_mv | 10.3390/ijms252313080 |
| format | Article |
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to cognitive impairment in the PIL mice model. A total of 76 female BALB/c mice were divided into pristane (P), pristane plus lipopolysaccharide (P plus LPS) and control (C) groups. In behavioral tests, the P group showed cognitive and visuospatial memory impairment. Elevated plasma OPN FL levels were found in P compared to C groups (177.7 ± 90.1 vs. 105.9 ± 56.8 ng/mL,
= 0.009) and OPN N-half was different between P and C groups (673.5 ± 144.6 vs. 624.5 ± 377.7 ng/mL,
= 0.028) and P plus LPS and C groups (624.5 ± 377.7 vs. 381.4 ± 205.0 ng/mL,
= 0.001). Anti-Sm correlated with OPN-FL (r = 0.269,
= 0.0150). The relative expression of
in the brain was 2.5 and 2.7-fold higher in P and P plus LPS groups, respectively. The evidence suggests that OPN is related to cognitive impairment in PIL mice and might play a relevant role in the detrimental neurological conditions of NPSLE.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms252313080</identifier><identifier>PMID: 39684790</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alzheimer's disease ; Animals ; Antigens ; Autoantibodies - blood ; Autoantibodies - immunology ; Cognitive ability ; Cognitive Dysfunction - chemically induced ; Cognitive Dysfunction - metabolism ; Disease ; Disease Models, Animal ; Female ; Lipopolysaccharides ; Lupus ; Lupus Erythematosus, Systemic - chemically induced ; Lupus Erythematosus, Systemic - metabolism ; Memory ; Mice ; Mice, Inbred BALB C ; Osteopontin - genetics ; Osteopontin - metabolism ; Terpenes</subject><ispartof>International journal of molecular sciences, 2024-12, Vol.25 (23), p.13080</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-6692-1246 ; 0000-0002-7267-1482 ; 0000-0001-6940-5899 ; 0000-0002-6756-4316 ; 0000-0001-9251-4209 ; 0000-0002-3823-4676 ; 0000-0002-6077-7925 ; 0009-0006-7130-7458</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39684790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González-Inostroz, Daniel</creatorcontrib><creatorcontrib>Sandoval-García, Flavio</creatorcontrib><creatorcontrib>Corona-Meraz, Fernanda-Isadora</creatorcontrib><creatorcontrib>Vázquez Del Mercado, Mónica</creatorcontrib><creatorcontrib>Guzmán-Muñiz, Jorge</creatorcontrib><creatorcontrib>Guzmán-Ornelas, Milton Omar</creatorcontrib><creatorcontrib>Castañeda-Arellano, Rolando</creatorcontrib><creatorcontrib>Bañuelos-Pineda, Jacinto</creatorcontrib><creatorcontrib>Peña-Nava, Miguel</creatorcontrib><creatorcontrib>Martín-Márquez, Beatriz-Teresita</creatorcontrib><title>The Association of Anti-Sm with Osteopontin Related to Cognitive Impairment in a Pristane-Induced Lupus BALB/c Mice Model</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The BALB/c model of pristane-induced lupus (PIL) exhibits cognitive impairment features resembling neuropsychiatric lupus (NPLSE). Osteopontin (OPN) is associated with disease activity in SLE; however, its involvement in NPLSE is not yet entirely determined. Our study aims to elucidate the contribution of full-length OPN (OPN-FL) plasma expression, OPN N-half, and
to cognitive impairment in the PIL mice model. A total of 76 female BALB/c mice were divided into pristane (P), pristane plus lipopolysaccharide (P plus LPS) and control (C) groups. In behavioral tests, the P group showed cognitive and visuospatial memory impairment. Elevated plasma OPN FL levels were found in P compared to C groups (177.7 ± 90.1 vs. 105.9 ± 56.8 ng/mL,
= 0.009) and OPN N-half was different between P and C groups (673.5 ± 144.6 vs. 624.5 ± 377.7 ng/mL,
= 0.028) and P plus LPS and C groups (624.5 ± 377.7 vs. 381.4 ± 205.0 ng/mL,
= 0.001). Anti-Sm correlated with OPN-FL (r = 0.269,
= 0.0150). The relative expression of
in the brain was 2.5 and 2.7-fold higher in P and P plus LPS groups, respectively. The evidence suggests that OPN is related to cognitive impairment in PIL mice and might play a relevant role in the detrimental neurological conditions of NPSLE.</description><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Antigens</subject><subject>Autoantibodies - blood</subject><subject>Autoantibodies - immunology</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - chemically induced</subject><subject>Cognitive Dysfunction - metabolism</subject><subject>Disease</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Lipopolysaccharides</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - chemically induced</subject><subject>Lupus Erythematosus, Systemic - metabolism</subject><subject>Memory</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Osteopontin - genetics</subject><subject>Osteopontin - metabolism</subject><subject>Terpenes</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkU1PGzEQhq0KRCjl2CuyxIXLBn_FiY9LRNtIQVQtnFdeezZxtGsvay8o_76OSkWLqjnM6NUzM69mEPpMyZRzRa7drotsxjjlZEE-oFMqGCsIkfOjv-oJ-hjjjhDG2UydoAlXciHmipyi_cMWcBljME4nFzwODS59csXPDr-4tMX3MUHoQ5Y8_gGtTmBxCngZNt4l9wx41fXaDR34hDOi8ffBxaQ9FCtvR5Pp9diPEd-U65trg--cAXwXLLSf0HGj2wjnr_kMPX65fVh-K9b3X1fLcl1sqCKkULW1NZNczoQxTBhqFalr1RAqba0Ub4ywkgOXQhAyt0xaRo02c80ENLWi_Axd_Z7bD-FphJiqzkUDbZs9hjFWnAqpqORUZfTyHboL4-CzuwMlqJL5gG_URrdQOd-ENGhzGFqVC6rUjBK5yNT0P1QOC50zwUPjsv5Pw8Xr8rHuwFb94Do97Ks_v-K_ACOpk1E</recordid><startdate>20241201</startdate><enddate>20241201</enddate><creator>González-Inostroz, Daniel</creator><creator>Sandoval-García, Flavio</creator><creator>Corona-Meraz, Fernanda-Isadora</creator><creator>Vázquez Del Mercado, Mónica</creator><creator>Guzmán-Muñiz, Jorge</creator><creator>Guzmán-Ornelas, Milton Omar</creator><creator>Castañeda-Arellano, Rolando</creator><creator>Bañuelos-Pineda, Jacinto</creator><creator>Peña-Nava, Miguel</creator><creator>Martín-Márquez, Beatriz-Teresita</creator><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6692-1246</orcidid><orcidid>https://orcid.org/0000-0002-7267-1482</orcidid><orcidid>https://orcid.org/0000-0001-6940-5899</orcidid><orcidid>https://orcid.org/0000-0002-6756-4316</orcidid><orcidid>https://orcid.org/0000-0001-9251-4209</orcidid><orcidid>https://orcid.org/0000-0002-3823-4676</orcidid><orcidid>https://orcid.org/0000-0002-6077-7925</orcidid><orcidid>https://orcid.org/0009-0006-7130-7458</orcidid></search><sort><creationdate>20241201</creationdate><title>The Association of Anti-Sm with Osteopontin Related to Cognitive Impairment in a Pristane-Induced Lupus BALB/c Mice Model</title><author>González-Inostroz, Daniel ; Sandoval-García, Flavio ; Corona-Meraz, Fernanda-Isadora ; Vázquez Del Mercado, Mónica ; Guzmán-Muñiz, Jorge ; Guzmán-Ornelas, Milton Omar ; Castañeda-Arellano, Rolando ; Bañuelos-Pineda, Jacinto ; Peña-Nava, Miguel ; Martín-Márquez, Beatriz-Teresita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g1900-9bddb263654cc24c1d90bb9f016db993fc4d63e3644007d26d21cac7a24efb913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Antigens</topic><topic>Autoantibodies - blood</topic><topic>Autoantibodies - immunology</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - chemically induced</topic><topic>Cognitive Dysfunction - metabolism</topic><topic>Disease</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Lipopolysaccharides</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - chemically induced</topic><topic>Lupus Erythematosus, Systemic - metabolism</topic><topic>Memory</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Osteopontin - genetics</topic><topic>Osteopontin - metabolism</topic><topic>Terpenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González-Inostroz, Daniel</creatorcontrib><creatorcontrib>Sandoval-García, Flavio</creatorcontrib><creatorcontrib>Corona-Meraz, Fernanda-Isadora</creatorcontrib><creatorcontrib>Vázquez Del Mercado, Mónica</creatorcontrib><creatorcontrib>Guzmán-Muñiz, Jorge</creatorcontrib><creatorcontrib>Guzmán-Ornelas, Milton Omar</creatorcontrib><creatorcontrib>Castañeda-Arellano, Rolando</creatorcontrib><creatorcontrib>Bañuelos-Pineda, Jacinto</creatorcontrib><creatorcontrib>Peña-Nava, Miguel</creatorcontrib><creatorcontrib>Martín-Márquez, Beatriz-Teresita</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González-Inostroz, Daniel</au><au>Sandoval-García, Flavio</au><au>Corona-Meraz, Fernanda-Isadora</au><au>Vázquez Del Mercado, Mónica</au><au>Guzmán-Muñiz, Jorge</au><au>Guzmán-Ornelas, Milton Omar</au><au>Castañeda-Arellano, Rolando</au><au>Bañuelos-Pineda, Jacinto</au><au>Peña-Nava, Miguel</au><au>Martín-Márquez, Beatriz-Teresita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Association of Anti-Sm with Osteopontin Related to Cognitive Impairment in a Pristane-Induced Lupus BALB/c Mice Model</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>25</volume><issue>23</issue><spage>13080</spage><pages>13080-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>The BALB/c model of pristane-induced lupus (PIL) exhibits cognitive impairment features resembling neuropsychiatric lupus (NPLSE). Osteopontin (OPN) is associated with disease activity in SLE; however, its involvement in NPLSE is not yet entirely determined. Our study aims to elucidate the contribution of full-length OPN (OPN-FL) plasma expression, OPN N-half, and
to cognitive impairment in the PIL mice model. A total of 76 female BALB/c mice were divided into pristane (P), pristane plus lipopolysaccharide (P plus LPS) and control (C) groups. In behavioral tests, the P group showed cognitive and visuospatial memory impairment. Elevated plasma OPN FL levels were found in P compared to C groups (177.7 ± 90.1 vs. 105.9 ± 56.8 ng/mL,
= 0.009) and OPN N-half was different between P and C groups (673.5 ± 144.6 vs. 624.5 ± 377.7 ng/mL,
= 0.028) and P plus LPS and C groups (624.5 ± 377.7 vs. 381.4 ± 205.0 ng/mL,
= 0.001). Anti-Sm correlated with OPN-FL (r = 0.269,
= 0.0150). The relative expression of
in the brain was 2.5 and 2.7-fold higher in P and P plus LPS groups, respectively. The evidence suggests that OPN is related to cognitive impairment in PIL mice and might play a relevant role in the detrimental neurological conditions of NPSLE.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39684790</pmid><doi>10.3390/ijms252313080</doi><orcidid>https://orcid.org/0000-0002-6692-1246</orcidid><orcidid>https://orcid.org/0000-0002-7267-1482</orcidid><orcidid>https://orcid.org/0000-0001-6940-5899</orcidid><orcidid>https://orcid.org/0000-0002-6756-4316</orcidid><orcidid>https://orcid.org/0000-0001-9251-4209</orcidid><orcidid>https://orcid.org/0000-0002-3823-4676</orcidid><orcidid>https://orcid.org/0000-0002-6077-7925</orcidid><orcidid>https://orcid.org/0009-0006-7130-7458</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2024-12, Vol.25 (23), p.13080 |
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| source | MEDLINE; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Alzheimer's disease Animals Antigens Autoantibodies - blood Autoantibodies - immunology Cognitive ability Cognitive Dysfunction - chemically induced Cognitive Dysfunction - metabolism Disease Disease Models, Animal Female Lipopolysaccharides Lupus Lupus Erythematosus, Systemic - chemically induced Lupus Erythematosus, Systemic - metabolism Memory Mice Mice, Inbred BALB C Osteopontin - genetics Osteopontin - metabolism Terpenes |
| title | The Association of Anti-Sm with Osteopontin Related to Cognitive Impairment in a Pristane-Induced Lupus BALB/c Mice Model |
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