The Complex Connection Between Myocardial Dysfunction and Cancer Beyond Cardiotoxicity: Shared Risk Factors and Common Molecular Pathways
Cardiovascular diseases and cancer represent the largest disease burden worldwide. Previously, these two conditions were considered independent, except in terms of cardiotoxicity, which links cancer treatment to subsequent cardiovascular issues. However, recent studies suggest that there are further...
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| Veröffentlicht in: | International journal of molecular sciences 2024-12, Vol.25 (23), p.13185 |
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| creator | Molnár, Andrea Ágnes Birgés, Kristóf Surman, Adrienn Merkely, Béla |
| description | Cardiovascular diseases and cancer represent the largest disease burden worldwide. Previously, these two conditions were considered independent, except in terms of cardiotoxicity, which links cancer treatment to subsequent cardiovascular issues. However, recent studies suggest that there are further connections between cancer and heart disease beyond cardiotoxicity. It has been revealed that myocardial dysfunction may promote carcinogenesis, indicating that additional common pathophysiological mechanisms might be involved in the relationship between cardiology and oncology, rather than simply a connection through cardiotoxic effects. These mechanisms may include shared risk factors and common molecular pathways, such as persistent inflammation and neurohormonal activation. This review explores the connection between myocardial dysfunction and cancer, emphasizing their shared risk factors, similar biological mechanisms, and causative factors like cardiotoxicity, along with their clinical implications. |
| doi_str_mv | 10.3390/ijms252313185 |
| format | Article |
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| subjects | Animals Antineoplastic Agents - adverse effects B cells Breast cancer Cancer Cardiology Cardiomyopathies - etiology Cardiomyopathies - metabolism Cardiotoxicity - etiology Cardiovascular disease Cardiovascular diseases Care and treatment Cell growth Development and progression Humans Inflammation Kinases Neoplasms - metabolism Oncology, Experimental Risk Factors Signal Transduction |
| title | The Complex Connection Between Myocardial Dysfunction and Cancer Beyond Cardiotoxicity: Shared Risk Factors and Common Molecular Pathways |
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