Safety and Efficacy Analysis of Targeted and Immune Combination Therapy in Advanced Melanoma-A Systematic Review and Network Meta-Analysis

The combinations of BRAF inhibitor-based targeted therapies with immune checkpoint inhibitors currently represent less common therapeutic approaches in advanced melanoma. The aim of this study was to assess the safety and efficacy of currently available melanoma treatments by conducting a systematic...

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Veröffentlicht in:	International journal of molecular sciences 2024-12, Vol.25 (23), p.12821
Hauptverfasser:	Lengyel, Anna Sára, Meznerics, Fanni Adél, Galajda, Noémi Ágnes, Gede, Noémi, Kói, Tamás, Mohammed, Alzahra Ahmed, Péter, Petra Nikolett, Lakatos, Alexandra It, Krebs, Máté, Csupor, Dezső, Bánvölgyi, András, Hegyi, Péter, Holló, Péter, Kemény, Lajos V
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antimitotic agents Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bias Cancer Chemotherapy Clinical trials Combination therapy Complications and side effects Humans Immune Checkpoint Inhibitors - adverse effects Immune Checkpoint Inhibitors - therapeutic use Immunotherapy Immunotherapy - methods Inflammatory bowel disease Intervention Kinases Libraries Medical research Medicine, Experimental Melanoma Melanoma - drug therapy Melanoma - pathology Meta-analysis Molecular Targeted Therapy - adverse effects Network Meta-Analysis Progression-Free Survival Protein Kinase Inhibitors - adverse effects Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - genetics Signal transduction Software Statistical analysis Systematic review Treatment Outcome
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