Frequencies of an IFNL4 Variant in an Admixed Population from Amazonia and Its Influence on Hepatitis C Infection
The rs12979860 polymorphism, related to the gene, is suggested as a factor that impacts fibrosis progression in hepatitis C virus (HCV) infection and exhibits a wide distribution pattern across global populations. In this retrospective cross-sectional study, we aimed to investigate the frequency of...
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| Veröffentlicht in: | International journal of molecular sciences 2024-12, Vol.25 (23), p.12764 |
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| creator | Angelim, Carolina Cabral Andrade, Álesson Adam Fonseca de Sousa, Renata Santos Correa, Raissa Lima Sacramento, Amanda Roberta Vieira Martins, Letícia Dias Conde, Simone Regina Souza da Silva Vallinoto, Antonio Carlos Rosário Feitosa, Rosimar Neris Martins Costa, Greice de Lemos Cardoso |
| description | The rs12979860 polymorphism, related to the
gene, is suggested as a factor that impacts fibrosis progression in hepatitis C virus (HCV) infection and exhibits a wide distribution pattern across global populations. In this retrospective cross-sectional study, we aimed to investigate the frequency of this variant in an Amazonian population from Brazil, as well as its association with liver fibrosis development and its staging in HCV carriers. Our results show a significant association of the TT genotype in the sample of patients with HCV (OR = 2.291; 95% CI = 1.088-4.826;
= 0.033) and the greater frequency of the T allele (62.1%), which is similar to the those of African populational groups. Populational genetics analysis showed significant differences in allele frequencies on global levels. The frequency of the C allele in the study population (37.8%) was like that of the African population (39.7%), and differed from all other populations, which ranged from 62.5% to 92.9%. These findings suggest that rs12979860 plays a role in susceptibility to hepatitis C. Additionally, they allow us to propose that the response to hepatitis C infection in this group may resemble that of the African population. |
| doi_str_mv | 10.3390/ijms252312764 |
| format | Article |
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gene, is suggested as a factor that impacts fibrosis progression in hepatitis C virus (HCV) infection and exhibits a wide distribution pattern across global populations. In this retrospective cross-sectional study, we aimed to investigate the frequency of this variant in an Amazonian population from Brazil, as well as its association with liver fibrosis development and its staging in HCV carriers. Our results show a significant association of the TT genotype in the sample of patients with HCV (OR = 2.291; 95% CI = 1.088-4.826;
= 0.033) and the greater frequency of the T allele (62.1%), which is similar to the those of African populational groups. Populational genetics analysis showed significant differences in allele frequencies on global levels. The frequency of the C allele in the study population (37.8%) was like that of the African population (39.7%), and differed from all other populations, which ranged from 62.5% to 92.9%. These findings suggest that rs12979860 plays a role in susceptibility to hepatitis C. Additionally, they allow us to propose that the response to hepatitis C infection in this group may resemble that of the African population.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms252312764</identifier><identifier>PMID: 39684474</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Aged ; Alleles ; Brazil - epidemiology ; Cross-Sectional Studies ; Development and progression ; Female ; Gene Frequency ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genotype ; Genotype & phenotype ; Health aspects ; Hepacivirus - genetics ; Hepacivirus - pathogenicity ; Hepatitis C ; Hepatitis C - epidemiology ; Hepatitis C - genetics ; Hepatitis C - virology ; Hepatitis C virus ; Humans ; Infection ; Infections ; Interferon Lambda ; Interleukins - genetics ; Liver ; Liver cancer ; Liver cirrhosis ; Liver Cirrhosis - epidemiology ; Liver Cirrhosis - genetics ; Liver Cirrhosis - virology ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Retrospective Studies ; Sociodemographics ; Viral infections</subject><ispartof>International journal of molecular sciences, 2024-12, Vol.25 (23), p.12764</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-2264-0493 ; 0000-0002-5479-4059 ; 0000-0002-8916-0283 ; 0000-0003-2195-0366 ; 0000-0002-5572-0561 ; 0000-0003-0278-4972 ; 0000-0003-1135-6507 ; 0000-0003-2044-9350</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39684474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Angelim, Carolina Cabral</creatorcontrib><creatorcontrib>Andrade, Álesson Adam Fonseca</creatorcontrib><creatorcontrib>de Sousa, Renata Santos</creatorcontrib><creatorcontrib>Correa, Raissa Lima</creatorcontrib><creatorcontrib>Sacramento, Amanda Roberta Vieira</creatorcontrib><creatorcontrib>Martins, Letícia Dias</creatorcontrib><creatorcontrib>Conde, Simone Regina Souza da Silva</creatorcontrib><creatorcontrib>Vallinoto, Antonio Carlos Rosário</creatorcontrib><creatorcontrib>Feitosa, Rosimar Neris Martins</creatorcontrib><creatorcontrib>Costa, Greice de Lemos Cardoso</creatorcontrib><title>Frequencies of an IFNL4 Variant in an Admixed Population from Amazonia and Its Influence on Hepatitis C Infection</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The rs12979860 polymorphism, related to the
gene, is suggested as a factor that impacts fibrosis progression in hepatitis C virus (HCV) infection and exhibits a wide distribution pattern across global populations. In this retrospective cross-sectional study, we aimed to investigate the frequency of this variant in an Amazonian population from Brazil, as well as its association with liver fibrosis development and its staging in HCV carriers. Our results show a significant association of the TT genotype in the sample of patients with HCV (OR = 2.291; 95% CI = 1.088-4.826;
= 0.033) and the greater frequency of the T allele (62.1%), which is similar to the those of African populational groups. Populational genetics analysis showed significant differences in allele frequencies on global levels. The frequency of the C allele in the study population (37.8%) was like that of the African population (39.7%), and differed from all other populations, which ranged from 62.5% to 92.9%. These findings suggest that rs12979860 plays a role in susceptibility to hepatitis C. Additionally, they allow us to propose that the response to hepatitis C infection in this group may resemble that of the African population.</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Brazil - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Development and progression</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Health aspects</subject><subject>Hepacivirus - genetics</subject><subject>Hepacivirus - pathogenicity</subject><subject>Hepatitis C</subject><subject>Hepatitis C - epidemiology</subject><subject>Hepatitis C - genetics</subject><subject>Hepatitis C - virology</subject><subject>Hepatitis C virus</subject><subject>Humans</subject><subject>Infection</subject><subject>Infections</subject><subject>Interferon Lambda</subject><subject>Interleukins - 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gene, is suggested as a factor that impacts fibrosis progression in hepatitis C virus (HCV) infection and exhibits a wide distribution pattern across global populations. In this retrospective cross-sectional study, we aimed to investigate the frequency of this variant in an Amazonian population from Brazil, as well as its association with liver fibrosis development and its staging in HCV carriers. Our results show a significant association of the TT genotype in the sample of patients with HCV (OR = 2.291; 95% CI = 1.088-4.826;
= 0.033) and the greater frequency of the T allele (62.1%), which is similar to the those of African populational groups. Populational genetics analysis showed significant differences in allele frequencies on global levels. The frequency of the C allele in the study population (37.8%) was like that of the African population (39.7%), and differed from all other populations, which ranged from 62.5% to 92.9%. These findings suggest that rs12979860 plays a role in susceptibility to hepatitis C. Additionally, they allow us to propose that the response to hepatitis C infection in this group may resemble that of the African population.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39684474</pmid><doi>10.3390/ijms252312764</doi><orcidid>https://orcid.org/0000-0002-2264-0493</orcidid><orcidid>https://orcid.org/0000-0002-5479-4059</orcidid><orcidid>https://orcid.org/0000-0002-8916-0283</orcidid><orcidid>https://orcid.org/0000-0003-2195-0366</orcidid><orcidid>https://orcid.org/0000-0002-5572-0561</orcidid><orcidid>https://orcid.org/0000-0003-0278-4972</orcidid><orcidid>https://orcid.org/0000-0003-1135-6507</orcidid><orcidid>https://orcid.org/0000-0003-2044-9350</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Aged Alleles Brazil - epidemiology Cross-Sectional Studies Development and progression Female Gene Frequency Genes Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Genotype Genotype & phenotype Health aspects Hepacivirus - genetics Hepacivirus - pathogenicity Hepatitis C Hepatitis C - epidemiology Hepatitis C - genetics Hepatitis C - virology Hepatitis C virus Humans Infection Infections Interferon Lambda Interleukins - genetics Liver Liver cancer Liver cirrhosis Liver Cirrhosis - epidemiology Liver Cirrhosis - genetics Liver Cirrhosis - virology Male Middle Aged Polymorphism, Single Nucleotide Retrospective Studies Sociodemographics Viral infections |
| title | Frequencies of an IFNL4 Variant in an Admixed Population from Amazonia and Its Influence on Hepatitis C Infection |
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