2'-Hydroxycinnamaldehyde, a Natural Product from Cinnamon, Alleviates Ischemia/Reperfusion-Induced Microvascular Dysfunction and Oxidative Damage in Rats by Upregulating Cytosolic BAG3 and Nrf2/HO-1

2'-Hydroxycinnamaldehyde (HCA), a natural product isolated from the bark of , has anti-inflammatory and anti-tumor activities. In this study, we explored whether HCA preconditioning could protect the heart against ischemia/reperfusion (I/R)-induced oxidative injury through cytosolic Bcl-2-assoc...

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Veröffentlicht in:	International journal of molecular sciences 2024-12, Vol.25 (23), p.12962
Hauptverfasser:	Cheng, Yu-Hsuan, Chiang, Chih-Yao, Wu, Chung-Hsin, Chien, Chiang-Ting
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Autophagy Biological Products - chemistry Biological Products - pharmacology Biological Products - therapeutic use Biomarkers Cardiology Cardiomyocytes Cardiovascular disease Cell death Cinnamomum aromaticum - chemistry Cytochrome Cytosol - drug effects Cytosol - metabolism Electrocardiogram Electrocardiography Ferroptosis Heart attacks Heart rate Heme Oxygenase (Decyclizing) - metabolism Immunohistochemistry Ischemia Leukocytes Male Microvessels - drug effects Microvessels - metabolism Microvessels - pathology Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology NF-E2-Related Factor 2 - metabolism Ostomy Oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar Reactive oxygen species Up-Regulation - drug effects Utrophin
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