Anti-Inflammatory Effects of Extracellular Vesicles from Ecklonia cava on 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation in Mice
Steroids, which are often used to treat the inflammation associated with various skin diseases, have several negative side effects. As extract has anti-inflammatory effects in various diseases, we evaluated the efficacy of -derived extracellular vesicles (EVEs) in decreasing 12-O-tetradecanoylphorbo...
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| Veröffentlicht in: | International journal of molecular sciences 2024-12, Vol.25 (23), p.12522 |
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| creator | Kim, Geebum Lee, So Young Oh, Seyeon Jang, Jong-Won Lee, Jehyuk Kim, Hyun-Seok Son, Kuk Hui Byun, Kyunghee |
| description | Steroids, which are often used to treat the inflammation associated with various skin diseases, have several negative side effects. As
extract has anti-inflammatory effects in various diseases, we evaluated the efficacy of
-derived extracellular vesicles (EVEs) in decreasing 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. We determined the effect of the EVEs on the TLR4/NF-κB/NLRP3 inflammasome in human keratinocytes and mouse ear skin. TPA-treated human keratinocytes showed an increased expression of TLR4 and its ligands HMGB1 and S100A8. TPA also increased the expression of (1) NF-κB; (2) the NLRP3 inflammasome components NLRP3, ASC, and caspase 1; and (3) the pyroptosis-related factors GSDMD-NT, IL-18, and IL-1β. However, the expression of these molecules decreased in the TPA-treated human keratinocytes after EVE treatment. Similar to the in vitro results, TPA increased the expression of these molecules in mouse ear skin, and EVE treatment decreased their expression. The TPA treatment of skin increased edema, redness, neutrophil infiltration, and epidermal thickness, and EVE reduced these symptoms of inflammation. In conclusion, the EVEs decreased TPA-induced skin inflammation, which was associated with a decrease in the TLR4/NF-κB/NLRP3 inflammasome. |
| doi_str_mv | 10.3390/ijms252312522 |
| format | Article |
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extract has anti-inflammatory effects in various diseases, we evaluated the efficacy of
-derived extracellular vesicles (EVEs) in decreasing 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. We determined the effect of the EVEs on the TLR4/NF-κB/NLRP3 inflammasome in human keratinocytes and mouse ear skin. TPA-treated human keratinocytes showed an increased expression of TLR4 and its ligands HMGB1 and S100A8. TPA also increased the expression of (1) NF-κB; (2) the NLRP3 inflammasome components NLRP3, ASC, and caspase 1; and (3) the pyroptosis-related factors GSDMD-NT, IL-18, and IL-1β. However, the expression of these molecules decreased in the TPA-treated human keratinocytes after EVE treatment. Similar to the in vitro results, TPA increased the expression of these molecules in mouse ear skin, and EVE treatment decreased their expression. The TPA treatment of skin increased edema, redness, neutrophil infiltration, and epidermal thickness, and EVE reduced these symptoms of inflammation. In conclusion, the EVEs decreased TPA-induced skin inflammation, which was associated with a decrease in the TLR4/NF-κB/NLRP3 inflammasome.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms252312522</identifier><identifier>PMID: 39684233</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acetates ; Animal skins ; Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-inflammatory drugs ; Apoptosis ; Cell death ; Chromosomal proteins ; Complications and side effects ; Dermatitis ; Dermatitis - drug therapy ; Dermatitis - etiology ; Dermatitis - metabolism ; Dermatitis - pathology ; Dermatologic agents ; Dermatology ; Extracellular vesicles ; Extracellular Vesicles - drug effects ; Extracellular Vesicles - metabolism ; Formulae, receipts, prescriptions ; Humans ; Inflammasomes - drug effects ; Inflammasomes - metabolism ; Inflammation ; Inflammation - chemically induced ; Inflammation - drug therapy ; Inflammation - metabolism ; Inflammation - pathology ; Inflammatory diseases ; Keratinocytes - drug effects ; Keratinocytes - metabolism ; Kinases ; Mice ; NF-kappa B - metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism ; Oxidative stress ; Pathogens ; Phaeophyceae - chemistry ; Proteins ; Psoriasis ; Skin ; Skin - drug effects ; Skin - metabolism ; Skin - pathology ; Skin diseases ; Tetradecanoylphorbol Acetate - adverse effects ; Tetradecanoylphorbol Acetate - toxicity ; Toll-Like Receptor 4 - metabolism ; Tumor necrosis factor-TNF</subject><ispartof>International journal of molecular sciences, 2024-12, Vol.25 (23), p.12522</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-0595-5645 ; 0000-0003-3036-4617</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39684233$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Geebum</creatorcontrib><creatorcontrib>Lee, So Young</creatorcontrib><creatorcontrib>Oh, Seyeon</creatorcontrib><creatorcontrib>Jang, Jong-Won</creatorcontrib><creatorcontrib>Lee, Jehyuk</creatorcontrib><creatorcontrib>Kim, Hyun-Seok</creatorcontrib><creatorcontrib>Son, Kuk Hui</creatorcontrib><creatorcontrib>Byun, Kyunghee</creatorcontrib><title>Anti-Inflammatory Effects of Extracellular Vesicles from Ecklonia cava on 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation in Mice</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Steroids, which are often used to treat the inflammation associated with various skin diseases, have several negative side effects. As
extract has anti-inflammatory effects in various diseases, we evaluated the efficacy of
-derived extracellular vesicles (EVEs) in decreasing 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. We determined the effect of the EVEs on the TLR4/NF-κB/NLRP3 inflammasome in human keratinocytes and mouse ear skin. TPA-treated human keratinocytes showed an increased expression of TLR4 and its ligands HMGB1 and S100A8. TPA also increased the expression of (1) NF-κB; (2) the NLRP3 inflammasome components NLRP3, ASC, and caspase 1; and (3) the pyroptosis-related factors GSDMD-NT, IL-18, and IL-1β. However, the expression of these molecules decreased in the TPA-treated human keratinocytes after EVE treatment. Similar to the in vitro results, TPA increased the expression of these molecules in mouse ear skin, and EVE treatment decreased their expression. The TPA treatment of skin increased edema, redness, neutrophil infiltration, and epidermal thickness, and EVE reduced these symptoms of inflammation. In conclusion, the EVEs decreased TPA-induced skin inflammation, which was associated with a decrease in the TLR4/NF-κB/NLRP3 inflammasome.</description><subject>Acetates</subject><subject>Animal skins</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-inflammatory drugs</subject><subject>Apoptosis</subject><subject>Cell death</subject><subject>Chromosomal proteins</subject><subject>Complications and side effects</subject><subject>Dermatitis</subject><subject>Dermatitis - drug therapy</subject><subject>Dermatitis - etiology</subject><subject>Dermatitis - metabolism</subject><subject>Dermatitis - pathology</subject><subject>Dermatologic agents</subject><subject>Dermatology</subject><subject>Extracellular vesicles</subject><subject>Extracellular Vesicles - drug effects</subject><subject>Extracellular Vesicles - metabolism</subject><subject>Formulae, receipts, prescriptions</subject><subject>Humans</subject><subject>Inflammasomes - drug effects</subject><subject>Inflammasomes - metabolism</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Inflammatory diseases</subject><subject>Keratinocytes - drug effects</subject><subject>Keratinocytes - metabolism</subject><subject>Kinases</subject><subject>Mice</subject><subject>NF-kappa B - metabolism</subject><subject>NLR Family, Pyrin Domain-Containing 3 Protein - metabolism</subject><subject>Oxidative stress</subject><subject>Pathogens</subject><subject>Phaeophyceae - chemistry</subject><subject>Proteins</subject><subject>Psoriasis</subject><subject>Skin</subject><subject>Skin - drug effects</subject><subject>Skin - metabolism</subject><subject>Skin - pathology</subject><subject>Skin diseases</subject><subject>Tetradecanoylphorbol Acetate - adverse effects</subject><subject>Tetradecanoylphorbol Acetate - toxicity</subject><subject>Toll-Like Receptor 4 - 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pharmacology</topic><topic>Anti-inflammatory drugs</topic><topic>Apoptosis</topic><topic>Cell death</topic><topic>Chromosomal proteins</topic><topic>Complications and side effects</topic><topic>Dermatitis</topic><topic>Dermatitis - drug therapy</topic><topic>Dermatitis - etiology</topic><topic>Dermatitis - metabolism</topic><topic>Dermatitis - pathology</topic><topic>Dermatologic agents</topic><topic>Dermatology</topic><topic>Extracellular vesicles</topic><topic>Extracellular Vesicles - drug effects</topic><topic>Extracellular Vesicles - metabolism</topic><topic>Formulae, receipts, prescriptions</topic><topic>Humans</topic><topic>Inflammasomes - drug effects</topic><topic>Inflammasomes - metabolism</topic><topic>Inflammation</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - pathology</topic><topic>Inflammatory diseases</topic><topic>Keratinocytes - drug effects</topic><topic>Keratinocytes - 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Academic</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Geebum</au><au>Lee, So Young</au><au>Oh, Seyeon</au><au>Jang, Jong-Won</au><au>Lee, Jehyuk</au><au>Kim, Hyun-Seok</au><au>Son, Kuk Hui</au><au>Byun, Kyunghee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Inflammatory Effects of Extracellular Vesicles from Ecklonia cava on 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation in Mice</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2024-12-01</date><risdate>2024</risdate><volume>25</volume><issue>23</issue><spage>12522</spage><pages>12522-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Steroids, which are often used to treat the inflammation associated with various skin diseases, have several negative side effects. As
extract has anti-inflammatory effects in various diseases, we evaluated the efficacy of
-derived extracellular vesicles (EVEs) in decreasing 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. We determined the effect of the EVEs on the TLR4/NF-κB/NLRP3 inflammasome in human keratinocytes and mouse ear skin. TPA-treated human keratinocytes showed an increased expression of TLR4 and its ligands HMGB1 and S100A8. TPA also increased the expression of (1) NF-κB; (2) the NLRP3 inflammasome components NLRP3, ASC, and caspase 1; and (3) the pyroptosis-related factors GSDMD-NT, IL-18, and IL-1β. However, the expression of these molecules decreased in the TPA-treated human keratinocytes after EVE treatment. Similar to the in vitro results, TPA increased the expression of these molecules in mouse ear skin, and EVE treatment decreased their expression. The TPA treatment of skin increased edema, redness, neutrophil infiltration, and epidermal thickness, and EVE reduced these symptoms of inflammation. In conclusion, the EVEs decreased TPA-induced skin inflammation, which was associated with a decrease in the TLR4/NF-κB/NLRP3 inflammasome.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39684233</pmid><doi>10.3390/ijms252312522</doi><orcidid>https://orcid.org/0000-0002-0595-5645</orcidid><orcidid>https://orcid.org/0000-0003-3036-4617</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acetates Animal skins Animals Anti-Inflammatory Agents - pharmacology Anti-inflammatory drugs Apoptosis Cell death Chromosomal proteins Complications and side effects Dermatitis Dermatitis - drug therapy Dermatitis - etiology Dermatitis - metabolism Dermatitis - pathology Dermatologic agents Dermatology Extracellular vesicles Extracellular Vesicles - drug effects Extracellular Vesicles - metabolism Formulae, receipts, prescriptions Humans Inflammasomes - drug effects Inflammasomes - metabolism Inflammation Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Inflammatory diseases Keratinocytes - drug effects Keratinocytes - metabolism Kinases Mice NF-kappa B - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Oxidative stress Pathogens Phaeophyceae - chemistry Proteins Psoriasis Skin Skin - drug effects Skin - metabolism Skin - pathology Skin diseases Tetradecanoylphorbol Acetate - adverse effects Tetradecanoylphorbol Acetate - toxicity Toll-Like Receptor 4 - metabolism Tumor necrosis factor-TNF |
| title | Anti-Inflammatory Effects of Extracellular Vesicles from Ecklonia cava on 12-O-Tetradecanoylphorbol-13-Acetate-Induced Skin Inflammation in Mice |
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