Mitochondrial-targeting strategies with homoharringtonine: A novel approach for chemoresistant rectal cancer

5-Fluorouracil (5-FU) resistance poses a significant challenge in the treatment of rectal cancer, driving the need for novel therapeutic strategies. In this study, we established 5-FU-resistant rectal cancer cell lines (SW837-r, SNU-C1-r) and identified homoharringtonine (HHT) as a potent and select...

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Veröffentlicht in:	Biochemical and biophysical research communications 2025-01, Vol.743, p.151141, Article 151141
Hauptverfasser:	Chenghao, Hu, Xuefeng, Liu, Junli, Pang, Ke, Wang, Haixia, Li, Guangyue, Hu, Qingqin, Luo, Feng, Wu
Format:	Artikel
Sprache:	eng
Schlagworte:	5-FU resistance Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cell Line, Tumor Drug Resistance, Neoplasm - drug effects DSS Fluorouracil - pharmacology Fluorouracil - therapeutic use HHT High-throughput drug screening Homoharringtonine - pharmacology Homoharringtonine - therapeutic use Humans Mice Mice, Inbred BALB C Mice, Nude Mitochondria - drug effects Mitochondria - metabolism Mitochondrial respiration Rectal cancer Rectal Neoplasms - drug therapy Rectal Neoplasms - metabolism Rectal Neoplasms - pathology Xenograft Model Antitumor Assays
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