Piceatannol-3′-O-β-D-glucopyranoside inhibits neuroexcitotoxicity and ferroptosis through NMDAR/NRF2/BACH1/ACSL4 pathway in acute ischemic stroke

Neuronal protection is a well-established method of acute ischemic stroke (AIS) treatment. The pharmacodynamic effect of Piceatannol-3′-O-β-D-glucopyranoside (Chinese name: Hartigan, QZZG) on AIS has been reported, but the molecular mechanism of this effect remains unknown. The purpose of this study...

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Veröffentlicht in:	Free radical biology & medicine 2025-02, Vol.227, p.667-679
Hauptverfasser:	Fan, Genhao, Liu, Jia, Liu, Menglin, Huang, Yuhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute ischemic stroke Animals Disease Models, Animal Ferroptosis Ferroptosis - drug effects Glucosides - pharmacology Humans Ischemic Stroke - drug therapy Ischemic Stroke - metabolism Ischemic Stroke - pathology Male Metabolomics Mice Network pharmacology Neuroexcitotoxicity Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotective Agents - pharmacology NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Piceatannol-3′-O-β-D-glucopyranoside Rats Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Signal Transduction - drug effects Stilbenes - pharmacology
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