Factors affecting inflammatory changes in congenital lung malformations
Aim of the study Patients with congenital lung malformation (CLM) may present pulmonary inflammatory changes. However, little is known about the factors influencing local inflammation. The aim of this study was to evaluate the factors that may affect inflammatory changes in CLM. Methods Patients wit...
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| Veröffentlicht in: | Pediatric surgery international 2024-12, Vol.41 (1), p.28, Article 28 |
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| creator | Zulli, Andrea Tocchioni, Francesca Oreglio, Chiara Caporalini, Chiara Buccoliero, Anna Maria Morabito, Antonino Morini, Francesco |
| description | Aim of the study
Patients with congenital lung malformation (CLM) may present pulmonary inflammatory changes. However, little is known about the factors influencing local inflammation. The aim of this study was to evaluate the factors that may affect inflammatory changes in CLM.
Methods
Patients with CLM operated upon between 2005 and 2021 were included. The grade of inflammation was defined with a purpose-made inflammatory score (IS) ranging from 0 to 5. The association of type of CLM and age at surgery with IS was analyzed. Results are means (standard deviation).
Main results
Data from 105 patients with CLM were collected, 56 had congenital pulmonary airways malformation (CPAM), 24 bronchopulmonary sequestration (BPS), and 25 congenital lobar emphysema (CLE). 91 patients (87%) had inflammatory changes. IS was 2.1 (1.5), 1.2 (1.0), and 1.3 (1.5) in CPAM, BPS, and CLE respectively (One-way ANOVA
p
= 0.0101). CPAM showed a significantly higher IS as compared with BPS (
p
= 0.0242) and CLE (
p
= 0.0495). Age at operation significantly correlated to IS (
r
2
= 0.14;
p
|
| doi_str_mv | 10.1007/s00383-024-05931-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3146847612</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3146847612</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-75fc1ffa89c18a1146776b5f9d1f9fd0b355398aa74a7717538533caa88126e13</originalsourceid><addsrcrecordid>eNp9kD1PwzAQhi0EoqXwBxhQJBaWgJ1L_DGiihakSiwwW1fXLqnyUexk6L_HJeVDDEw-nZ977_QQcsnoLaNU3AVKQUJKszylhQKW8iMyZjmIVEkGx7_qETkLYUMplcDVKRmB4iJXUozJfIama31I0DlrurJZJ2XjKqxrjO1dYt6wWdsQm4lpY9WUHVZJ1Ueuxsq1PnJl24RzcuKwCvbi8E7I6-zhZfqYLp7nT9P7RWqygnepKJxhzqFUhklkLOdC8GXh1Io55VZ0CUUBSiKKHIVgogBZABhEKVnGLYMJuRlyt759723odF0GY6sKG9v2QUOMlLngLIvo9R900_a-idftqVwA0LhsQrKBMr4NwVunt76s0e80o3qvWQ-addSsPzVrHoeuDtH9srar75EvrxGAAQjxK2rzP7v_if0AIQOHSw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3144733055</pqid></control><display><type>article</type><title>Factors affecting inflammatory changes in congenital lung malformations</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Zulli, Andrea ; Tocchioni, Francesca ; Oreglio, Chiara ; Caporalini, Chiara ; Buccoliero, Anna Maria ; Morabito, Antonino ; Morini, Francesco</creator><creatorcontrib>Zulli, Andrea ; Tocchioni, Francesca ; Oreglio, Chiara ; Caporalini, Chiara ; Buccoliero, Anna Maria ; Morabito, Antonino ; Morini, Francesco</creatorcontrib><description>Aim of the study
Patients with congenital lung malformation (CLM) may present pulmonary inflammatory changes. However, little is known about the factors influencing local inflammation. The aim of this study was to evaluate the factors that may affect inflammatory changes in CLM.
Methods
Patients with CLM operated upon between 2005 and 2021 were included. The grade of inflammation was defined with a purpose-made inflammatory score (IS) ranging from 0 to 5. The association of type of CLM and age at surgery with IS was analyzed. Results are means (standard deviation).
Main results
Data from 105 patients with CLM were collected, 56 had congenital pulmonary airways malformation (CPAM), 24 bronchopulmonary sequestration (BPS), and 25 congenital lobar emphysema (CLE). 91 patients (87%) had inflammatory changes. IS was 2.1 (1.5), 1.2 (1.0), and 1.3 (1.5) in CPAM, BPS, and CLE respectively (One-way ANOVA
p
= 0.0101). CPAM showed a significantly higher IS as compared with BPS (
p
= 0.0242) and CLE (
p
= 0.0495). Age at operation significantly correlated to IS (
r
2
= 0.14;
p
< 0.0001). Patients aged below 6 months at operation had lower IS [1.4 (1.2)] as compared to those over 6 months [2.0 (1.6)] (
p
= 0.018). Age at operation significantly correlated with the IS in CPAM (
r
2
= 0.17;
p
= 0.0016) and CLE (
r
2
= 0.47;
p
< 0.0001) patients.
Conclusions
Patients with CLMs often present inflammatory changes in their lungs. Grade of inflammation significantly correlates with age at surgery and type of anomaly, with CPAMs having the highest grade. These findings support early resection in patients with CLM, especially in case of CPAM.</description><identifier>ISSN: 1437-9813</identifier><identifier>ISSN: 0179-0358</identifier><identifier>EISSN: 1437-9813</identifier><identifier>DOI: 10.1007/s00383-024-05931-6</identifier><identifier>PMID: 39674987</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Bronchopulmonary Sequestration - complications ; Bronchopulmonary Sequestration - surgery ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Inflammation ; Lung - abnormalities ; Lung - surgery ; Male ; Medicine ; Medicine & Public Health ; Original Article ; Pediatric Surgery ; Pediatrics ; Pulmonary Emphysema - congenital ; Pulmonary Emphysema - surgery ; Retrospective Studies ; Surgery</subject><ispartof>Pediatric surgery international, 2024-12, Vol.41 (1), p.28, Article 28</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>Copyright Springer Nature B.V. Dec 2025</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-75fc1ffa89c18a1146776b5f9d1f9fd0b355398aa74a7717538533caa88126e13</cites><orcidid>0000-0001-6420-7025</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00383-024-05931-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00383-024-05931-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39674987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zulli, Andrea</creatorcontrib><creatorcontrib>Tocchioni, Francesca</creatorcontrib><creatorcontrib>Oreglio, Chiara</creatorcontrib><creatorcontrib>Caporalini, Chiara</creatorcontrib><creatorcontrib>Buccoliero, Anna Maria</creatorcontrib><creatorcontrib>Morabito, Antonino</creatorcontrib><creatorcontrib>Morini, Francesco</creatorcontrib><title>Factors affecting inflammatory changes in congenital lung malformations</title><title>Pediatric surgery international</title><addtitle>Pediatr Surg Int</addtitle><addtitle>Pediatr Surg Int</addtitle><description>Aim of the study
Patients with congenital lung malformation (CLM) may present pulmonary inflammatory changes. However, little is known about the factors influencing local inflammation. The aim of this study was to evaluate the factors that may affect inflammatory changes in CLM.
Methods
Patients with CLM operated upon between 2005 and 2021 were included. The grade of inflammation was defined with a purpose-made inflammatory score (IS) ranging from 0 to 5. The association of type of CLM and age at surgery with IS was analyzed. Results are means (standard deviation).
Main results
Data from 105 patients with CLM were collected, 56 had congenital pulmonary airways malformation (CPAM), 24 bronchopulmonary sequestration (BPS), and 25 congenital lobar emphysema (CLE). 91 patients (87%) had inflammatory changes. IS was 2.1 (1.5), 1.2 (1.0), and 1.3 (1.5) in CPAM, BPS, and CLE respectively (One-way ANOVA
p
= 0.0101). CPAM showed a significantly higher IS as compared with BPS (
p
= 0.0242) and CLE (
p
= 0.0495). Age at operation significantly correlated to IS (
r
2
= 0.14;
p
< 0.0001). Patients aged below 6 months at operation had lower IS [1.4 (1.2)] as compared to those over 6 months [2.0 (1.6)] (
p
= 0.018). Age at operation significantly correlated with the IS in CPAM (
r
2
= 0.17;
p
= 0.0016) and CLE (
r
2
= 0.47;
p
< 0.0001) patients.
Conclusions
Patients with CLMs often present inflammatory changes in their lungs. Grade of inflammation significantly correlates with age at surgery and type of anomaly, with CPAMs having the highest grade. These findings support early resection in patients with CLM, especially in case of CPAM.</description><subject>Bronchopulmonary Sequestration - complications</subject><subject>Bronchopulmonary Sequestration - surgery</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Inflammation</subject><subject>Lung - abnormalities</subject><subject>Lung - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Pulmonary Emphysema - congenital</subject><subject>Pulmonary Emphysema - surgery</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><issn>1437-9813</issn><issn>0179-0358</issn><issn>1437-9813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwBxhQJBaWgJ1L_DGiihakSiwwW1fXLqnyUexk6L_HJeVDDEw-nZ977_QQcsnoLaNU3AVKQUJKszylhQKW8iMyZjmIVEkGx7_qETkLYUMplcDVKRmB4iJXUozJfIama31I0DlrurJZJ2XjKqxrjO1dYt6wWdsQm4lpY9WUHVZJ1Ueuxsq1PnJl24RzcuKwCvbi8E7I6-zhZfqYLp7nT9P7RWqygnepKJxhzqFUhklkLOdC8GXh1Io55VZ0CUUBSiKKHIVgogBZABhEKVnGLYMJuRlyt759723odF0GY6sKG9v2QUOMlLngLIvo9R900_a-idftqVwA0LhsQrKBMr4NwVunt76s0e80o3qvWQ-addSsPzVrHoeuDtH9srar75EvrxGAAQjxK2rzP7v_if0AIQOHSw</recordid><startdate>20241215</startdate><enddate>20241215</enddate><creator>Zulli, Andrea</creator><creator>Tocchioni, Francesca</creator><creator>Oreglio, Chiara</creator><creator>Caporalini, Chiara</creator><creator>Buccoliero, Anna Maria</creator><creator>Morabito, Antonino</creator><creator>Morini, Francesco</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6420-7025</orcidid></search><sort><creationdate>20241215</creationdate><title>Factors affecting inflammatory changes in congenital lung malformations</title><author>Zulli, Andrea ; Tocchioni, Francesca ; Oreglio, Chiara ; Caporalini, Chiara ; Buccoliero, Anna Maria ; Morabito, Antonino ; Morini, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-75fc1ffa89c18a1146776b5f9d1f9fd0b355398aa74a7717538533caa88126e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Bronchopulmonary Sequestration - complications</topic><topic>Bronchopulmonary Sequestration - surgery</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Inflammation</topic><topic>Lung - abnormalities</topic><topic>Lung - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Pulmonary Emphysema - congenital</topic><topic>Pulmonary Emphysema - surgery</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zulli, Andrea</creatorcontrib><creatorcontrib>Tocchioni, Francesca</creatorcontrib><creatorcontrib>Oreglio, Chiara</creatorcontrib><creatorcontrib>Caporalini, Chiara</creatorcontrib><creatorcontrib>Buccoliero, Anna Maria</creatorcontrib><creatorcontrib>Morabito, Antonino</creatorcontrib><creatorcontrib>Morini, Francesco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric surgery international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zulli, Andrea</au><au>Tocchioni, Francesca</au><au>Oreglio, Chiara</au><au>Caporalini, Chiara</au><au>Buccoliero, Anna Maria</au><au>Morabito, Antonino</au><au>Morini, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors affecting inflammatory changes in congenital lung malformations</atitle><jtitle>Pediatric surgery international</jtitle><stitle>Pediatr Surg Int</stitle><addtitle>Pediatr Surg Int</addtitle><date>2024-12-15</date><risdate>2024</risdate><volume>41</volume><issue>1</issue><spage>28</spage><pages>28-</pages><artnum>28</artnum><issn>1437-9813</issn><issn>0179-0358</issn><eissn>1437-9813</eissn><abstract>Aim of the study
Patients with congenital lung malformation (CLM) may present pulmonary inflammatory changes. However, little is known about the factors influencing local inflammation. The aim of this study was to evaluate the factors that may affect inflammatory changes in CLM.
Methods
Patients with CLM operated upon between 2005 and 2021 were included. The grade of inflammation was defined with a purpose-made inflammatory score (IS) ranging from 0 to 5. The association of type of CLM and age at surgery with IS was analyzed. Results are means (standard deviation).
Main results
Data from 105 patients with CLM were collected, 56 had congenital pulmonary airways malformation (CPAM), 24 bronchopulmonary sequestration (BPS), and 25 congenital lobar emphysema (CLE). 91 patients (87%) had inflammatory changes. IS was 2.1 (1.5), 1.2 (1.0), and 1.3 (1.5) in CPAM, BPS, and CLE respectively (One-way ANOVA
p
= 0.0101). CPAM showed a significantly higher IS as compared with BPS (
p
= 0.0242) and CLE (
p
= 0.0495). Age at operation significantly correlated to IS (
r
2
= 0.14;
p
< 0.0001). Patients aged below 6 months at operation had lower IS [1.4 (1.2)] as compared to those over 6 months [2.0 (1.6)] (
p
= 0.018). Age at operation significantly correlated with the IS in CPAM (
r
2
= 0.17;
p
= 0.0016) and CLE (
r
2
= 0.47;
p
< 0.0001) patients.
Conclusions
Patients with CLMs often present inflammatory changes in their lungs. Grade of inflammation significantly correlates with age at surgery and type of anomaly, with CPAMs having the highest grade. These findings support early resection in patients with CLM, especially in case of CPAM.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39674987</pmid><doi>10.1007/s00383-024-05931-6</doi><orcidid>https://orcid.org/0000-0001-6420-7025</orcidid></addata></record> |
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| subjects | Bronchopulmonary Sequestration - complications Bronchopulmonary Sequestration - surgery Child Child, Preschool Female Humans Infant Infant, Newborn Inflammation Lung - abnormalities Lung - surgery Male Medicine Medicine & Public Health Original Article Pediatric Surgery Pediatrics Pulmonary Emphysema - congenital Pulmonary Emphysema - surgery Retrospective Studies Surgery |
| title | Factors affecting inflammatory changes in congenital lung malformations |
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