Clinical Significance of Incident Osteoporotic Fractures After Kidney Transplantation: A National Korean Cohort Study

Clinical Significance of Incident Osteoporotic Fractures After Kidney Transplantation: A National Korean Cohort Study

Recipients of kidney allografts are at risk for osteoporotic fractures (OF), but their association with patient and allograft outcomes remains uncertain due to common coexisting risks and complex medical conditions. This study sought to assess if overall incidence of OF among recipients of kidney al...

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Veröffentlicht in:American journal of kidney diseases 2024-12
Hauptverfasser: Jang, Yunyoung, Kim, Ji Eun, Park, Jina, Song, Jeongin, Park, Sehoon, Kim, Yong Chul, Kim, Dong Ki, Joo, Kwon Wook, Kim, Yon Su, Park, Minsu, Lee, Hajeong, Kang, Eunjeong
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container_title American journal of kidney diseases
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creator Jang, Yunyoung
Kim, Ji Eun
Park, Jina
Song, Jeongin
Park, Sehoon
Kim, Yong Chul
Kim, Dong Ki
Joo, Kwon Wook
Kim, Yon Su
Park, Minsu
Lee, Hajeong
Kang, Eunjeong
description Recipients of kidney allografts are at risk for osteoporotic fractures (OF), but their association with patient and allograft outcomes remains uncertain due to common coexisting risks and complex medical conditions. This study sought to assess if overall incidence of OF among recipients of kidney allografts compared to patients receiving maintenance dialysis for kidney failure. A national retrospective cohort study. & Participants: 145,090 Korean patients with newly diagnosed kidney failure between 2009 and 2019. Kidney transplantation vs dialysis for the outcome of OF. OF for the outcome of death. Incident osteoporotic fractures, overall and by site (hip, spine, forearm, and humerus); death. Comparison of patients receiving maintenance dialysis to recipients of kidney allografts matched for age, sex, year of new index date, duration of dialysis, and presence of hypertension and diabetes mellitus. Cause-specific Cox proportional hazards regression models estimated the association between modality of kidney replacement therapy and OF. Cox models incorporating OF as a time-updated covariate were used to estimate the association of OF and mortality. A total of 11,413 pairs were matched, and the rates of incident OF in allograft recipients and the matched dialysis comparators were 5.2% and 5.6%, respectively. After 5.5 years of follow-up, the risk of incident OF was lower in KT recipients compared to matched dialysis comparators (adjusted hazard ratio[aHR] 0.73; 95% confidence interval [CI], 0.64–0.84; P
doi_str_mv 10.1053/j.ajkd.2024.09.014
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This study sought to assess if overall incidence of OF among recipients of kidney allografts compared to patients receiving maintenance dialysis for kidney failure. A national retrospective cohort study. &amp; Participants: 145,090 Korean patients with newly diagnosed kidney failure between 2009 and 2019. Kidney transplantation vs dialysis for the outcome of OF. OF for the outcome of death. Incident osteoporotic fractures, overall and by site (hip, spine, forearm, and humerus); death. Comparison of patients receiving maintenance dialysis to recipients of kidney allografts matched for age, sex, year of new index date, duration of dialysis, and presence of hypertension and diabetes mellitus. Cause-specific Cox proportional hazards regression models estimated the association between modality of kidney replacement therapy and OF. Cox models incorporating OF as a time-updated covariate were used to estimate the association of OF and mortality. A total of 11,413 pairs were matched, and the rates of incident OF in allograft recipients and the matched dialysis comparators were 5.2% and 5.6%, respectively. After 5.5 years of follow-up, the risk of incident OF was lower in KT recipients compared to matched dialysis comparators (adjusted hazard ratio[aHR] 0.73; 95% confidence interval [CI], 0.64–0.84; P&lt;0.001). Differences in the rates of fracture were principally due to differences in hip fractures. Incident OF was associated with increased mortality risk (aHR 2.18; 95% CI, 1.57–3.02; P&lt;0.001), and death-censored allograft failure (aHR 1.42; 95% CI 1.02–1.97; P=0.040). No data on bone mineral density or hyperparathyroidism, and the definition of OFs used encompassed traumatic fractures. Use of claims data. 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This study sought to assess if overall incidence of OF among recipients of kidney allografts compared to patients receiving maintenance dialysis for kidney failure. A national retrospective cohort study. &amp; Participants: 145,090 Korean patients with newly diagnosed kidney failure between 2009 and 2019. Kidney transplantation vs dialysis for the outcome of OF. OF for the outcome of death. Incident osteoporotic fractures, overall and by site (hip, spine, forearm, and humerus); death. Comparison of patients receiving maintenance dialysis to recipients of kidney allografts matched for age, sex, year of new index date, duration of dialysis, and presence of hypertension and diabetes mellitus. Cause-specific Cox proportional hazards regression models estimated the association between modality of kidney replacement therapy and OF. Cox models incorporating OF as a time-updated covariate were used to estimate the association of OF and mortality. A total of 11,413 pairs were matched, and the rates of incident OF in allograft recipients and the matched dialysis comparators were 5.2% and 5.6%, respectively. After 5.5 years of follow-up, the risk of incident OF was lower in KT recipients compared to matched dialysis comparators (adjusted hazard ratio[aHR] 0.73; 95% confidence interval [CI], 0.64–0.84; P&lt;0.001). Differences in the rates of fracture were principally due to differences in hip fractures. Incident OF was associated with increased mortality risk (aHR 2.18; 95% CI, 1.57–3.02; P&lt;0.001), and death-censored allograft failure (aHR 1.42; 95% CI 1.02–1.97; P=0.040). No data on bone mineral density or hyperparathyroidism, and the definition of OFs used encompassed traumatic fractures. Use of claims data. 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title Clinical Significance of Incident Osteoporotic Fractures After Kidney Transplantation: A National Korean Cohort Study
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