Programming ADAR-recruiting hairpin RNA sensor to detect endogenous molecules

RNA editing leveraging ADARs (adenosine deaminases acting on RNA) shows promising potential for in vivo biosensing beyond gene therapy. However, current ADAR sensors sense only a single target of RNA transcripts, thus limiting their use in different biosensing scenarios. Here, we report a hairpin RN...

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Veröffentlicht in:	Nucleic acids research 2024-12
Hauptverfasser:	Qin, Pei-Pei, Chen, Pin-Ru, Tan, Liu, Chu, Xiaohe, Ye, Bang-Ce, Yin, Bin-Cheng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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