Neurotoxicity and Rare Adverse Events in BCMA-Directed CAR T Cell Therapy: A Comprehensive Analysis of Real-World FAERS Data

•Neurotoxic adverse events were observed in both cilta-cel and ide-cel, with distinct manifestations. Cilta-cel neurotoxicity manifested as cranial nerve palsies, parkinsonism, and polyneuropathies, while ide-cel was associated with confusion, disorientation, seizures, and tremors.•Significant safet...

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Veröffentlicht in:	Transplantation and cellular therapy 2024-12
Hauptverfasser:	Ellithi, Moataz, Elsallab, Magdi, Lunning, Matthew A., Holstein, Sarah A., Sharma, Smriti, Trinh, Jonathan Q., Ma, Jihyun, Maus, Marcela V., Frigault, Matthew J., D'Angelo, Christopher R.
Format:	Artikel
Sprache:	eng
Schlagworte:	CAR T FDA Myeloma Neurotoxicity Postmarketing Safety
Online-Zugang:	Volltext
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