Comparisons of the bioavailability of icariin, icariside II, and epimedin C in rats after oral administration of total flavonoids of Epimedium brevicornu Maxim. and its three formulations

The low bioavailability of insoluble flavonoids in the total flavonoids of Epimedium brevicornu Maxim. (TFE) severely hindered its clinical efficacy exertion. This research attempted to evaluate the promoting effects of pharmaceutical strategies, including nanosuspensions (NS), cyclodextrin inclusio...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2025-03, Vol.255, p.116631, Article 116631
Hauptverfasser:	Ding, Zhiyuan, Chen, Xiuping, Tang, Dongyun, Ye, Taiwei, Yang, Juan, Yu, Yilin, Xie, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclodextrin inclusion complexes Nanosuspensions Oral bioavailability Solid dispersions Total flavonoids of Epimedium brevicornu Maxim UPLC-MS/MS
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