Damsin and neoambrosin: Two sesquiterpene lactones with affinity and different activity for PPAR and TRPA1 receptors

[Display omitted] •Ambrosia maritima L. (family Asteraceae) is a widely distributed medicinal herb.•Damsin and neoambrosin, were isolated and confirmed by NMR and HR-ESI-MS/MS.•Neoambrosin showed a selective partial agonist effect on PPARγ receptors and TRPA1 channels.•The binding interactions of ne...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic chemistry 2025-01, Vol.154, p.108032, Article 108032
Hauptverfasser:	Abdel-dayem, Shymaa I.A., Otify, Asmaa M., Iannotti, Fabio Arturo, Saber, Fatema R., Moriello, Aniello Schiano, Giovannuzzi, Simone, Świątek, Łukasz, Bonardi, Alessandro, Gratteri, Paola, Skalicka-Woźniak, Krystyna, Supuran, Claudiu T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ambrosia maritima Carbonic anhydrase Damsin Dose-Response Relationship, Drug HEK293 Cells Humans Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology Molecular docking Molecular Docking Simulation Molecular Structure Neoambrosin Peroxisome Proliferator-Activated Receptors - metabolism PPAR Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Structure-Activity Relationship TRPA1 TRPA1 Cation Channel - antagonists & inhibitors TRPA1 Cation Channel - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!