In Silico Enabled Discovery of KAI-11101, a Preclinical DLK Inhibitor for the Treatment of Neurodegenerative Disease and Neuronal Injury

Dual leucine zipper kinase (DLK), expressed primarily in neuronal cells, is a regulator of neuronal degeneration in response to cellular stress from chronic disease or neuronal injury. This makes it an attractive target for the treatment of neurodegenerative diseases such as Alzheimer's, Parkin...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-12
Hauptverfasser:	Lagiakos, H Rachel, Zou, Yefen, Igawa, Hideyuki, Therrien, Eric, Lawrenz, Morgan, Kato, Mitsunori, Svensson, Mats, Gray, Felicia, Jensen, Kristian, Dahlgren, Markus K, Pelletier, Robert D, Dingley, Karen, Bell, Jeffrey A, Liu, Zhijian, Jiang, Yuansong, Zhou, Hua, Skene, Robert J, Nie, Zhe
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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