Functional Characterization of SLC2A3 in Rheumatoid Arthritis: Unraveling Its Role in Ferroptosis and Inflammatory Pathways

ABSTRACT Background Hence, we investigated that the function and effects of SLC2A3 in rheumatoid arthritis (RA) and the underlying mechanism. Methods C57BL/6 mice were immunized with bovine type II collagen to induce mice model of RA. Results The expression of serum SLC2A3 was down‐regulated, and wa...

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Veröffentlicht in:	International journal of rheumatic diseases 2024-12, Vol.27 (12), p.e70009-n/a
Hauptverfasser:	Lin, Zhiping, Li, Peng, Wang, Chaojun, Tan, Hongchang
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Case-Control Studies Cell differentiation Cell Differentiation - drug effects Collagen Type II Female Ferroptosis Ferroptosis - drug effects Gene expression Humans Inflammation Inflammation Mediators - metabolism Male Mice Mice, Inbred C57BL Middle Aged mitochondrial damage mRNA Osteogenesis - drug effects Protein expression Proteins Rheumatoid arthritis Signal Transduction SLC2A3 Tiam1 Tiam1 protein
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