Safety, tolerability, pharmacokinetics, and neutralisation activities of the anti-HIV-1 monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS in adults without HIV in the USA (HVTN 136/HPTN 092): a first-in-human, open-label, randomised controlled phase 1 trial

Multiple broadly neutralising monoclonal antibodies (mAbs) are in development for HIV-1 prevention. The aim of this trial was to test the PGT121.414.LS and VRC07-523LS mAbs for safety and pharmacokinetics in adults. In this first-in-human phase 1 trial (HVTN 136/HPTN 092), adults without HIV were en...

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Veröffentlicht in:The lancet HIV 2025-01, Vol.12 (1), p.e13-e25
Hauptverfasser: Edupuganti, Srilatha, Hurt, Christopher B, Stephenson, Kathryn E, Huang, Yunda, Paez, Carmen A, Yu, Chenchen, Yen, Catherine, Hanscom, Brett, He, Zonglin, Miner, Maurine D, Gamble, Theresa, Heptinstall, Jack, Seaton, Kelly E, Domin, Elizabeth, Lin, Bob C, McKee, Krisha, Doria-Rose, Nicole, Regenold, Stephanie, Spiegel, Hans, Anderson, Maija, McClosky, Nadia, Zhang, Lily, Piwowar-Manning, Estelle, Ackerman, Margaret E, Pensiero, Michael, Dye, Bonnie J, Landovitz, Raphael J, Mayer, Kenneth, Siegel, Marc, Sobieszczyk, Magdalena, Walsh, Stephen R, Gama, Lucio, Barouch, Dan H, Montefiori, David C, Tomaras, Georgia D, Ackerley, Cassie Grimsley, Graciaa, Daniel, Kelley, Colleen, Rouphael, Nadine, Curate-Ingram, Sharon, Korber, Bette, Wagh, Kshitij, Sane, Nandini, Grossman, Jennifer, Hasan, Sophie, Robinson, Michelle, Lucas, Jonathan, Gildea, Marianne, Babinec, Amber, Coomes, Bethany, Dumond, Julie, Beck, Justine, Chege, Wairimu, Han, Xue, Hanke, Jen, Karg, Carissa, Rinn, Laurie, Chicurel-Bayard, Miriam, Nagar, Shashikala, White, Hakeem, Cooley, W Scott, Broder, Gail, Hunt, Machel, Cummings, Vanessa, Donaty, Kristine, Randhawa, April, Fair, Ramey, Darden-Tabb, Noshima, Chaturvedi, Richa, Baden, Lindsey, Sherman, Amy, Gothing, Jon, Paz, Andres Avila, Klopfer, Julia, Powell, Megan, Piermattei, Anna, Heithoff, August, Weiner, Joshua A., Kovacikova, Gabriela, Axelrod, Katherine S., Zhang, Lu, Baral, Saman, Yates, Nicole, Chiong, Kelvin, Kuo, Irene, Jordan, Jeanne, Lintner, Madison, Langlands, Kayley, Saintilma, Bitana, Yellin, Hannah, Balachandran, Madhu, Magnus, Manya, Baumblatt, Jane, Tindale, India, Fortier, Samantha, Khodabakhshian, Aleen, Pierce, Nick, Gonzalez, Maricela, Mark, Lisa, Afemata, Ste'von
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