Safety, tolerability, pharmacokinetics, and neutralisation activities of the anti-HIV-1 monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS in adults without HIV in the USA (HVTN 136/HPTN 092): a first-in-human, open-label, randomised controlled phase 1 trial
Multiple broadly neutralising monoclonal antibodies (mAbs) are in development for HIV-1 prevention. The aim of this trial was to test the PGT121.414.LS and VRC07-523LS mAbs for safety and pharmacokinetics in adults. In this first-in-human phase 1 trial (HVTN 136/HPTN 092), adults without HIV were en...
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Veröffentlicht in: | The lancet HIV 2025-01, Vol.12 (1), p.e13-e25 |
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Sprache: | eng |
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