Salmonella-based therapeutic strategies: improving tumor microenvironment and bringing new hope for cancer immunotherapy
Immunotherapy has revolutionized cancer treatment, yet its effectiveness is limited by immunosuppressive tumor microenvironment (TME). To overcome this challenge, innovative strategies to effectively modulate the TME are urgently needed. Over the past decades, bacteria-mediated cancer immunotherapy...
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| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2024-12, Vol.42 (1), p.27, Article 27 |
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| creator | He, Xiaoe Guo, Jiayin Bai, Yanrui Sun, Hui Yang, Jing |
| description | Immunotherapy has revolutionized cancer treatment, yet its effectiveness is limited by immunosuppressive tumor microenvironment (TME). To overcome this challenge, innovative strategies to effectively modulate the TME are urgently needed. Over the past decades, bacteria-mediated cancer immunotherapy has recaptured increasing attention, driven by advances in synthetic biology, genetic engineering and our knowledge of host–pathogen interactions. Among various bacterial species,
Salmonella
has emerged as a leading candidate with significant therapeutic potential due to its broad-spectrum anti-tumor activity, tumor-targeting ability, immunomodulatory effects, oncolytic properties, genetic programmability, and engineering flexibility. These characteristics enable
Salmonella
to reshape the immunosuppressive TME, thereby enhancing anti-tumor efficacy. This review elaborates the regulatory effects of
Salmonella
on key components of the TME, the versatile engineering strategies for optimizing
Salmonella
’s ability to modulate the TME, and recent advancements in combination cancer therapies. We also summarize current clinical applications and discuss challenges of developing safer and more effective
Salmonella
-based cancer immunotherapy. |
| doi_str_mv | 10.1007/s12032-024-02578-0 |
| format | Article |
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Salmonella
has emerged as a leading candidate with significant therapeutic potential due to its broad-spectrum anti-tumor activity, tumor-targeting ability, immunomodulatory effects, oncolytic properties, genetic programmability, and engineering flexibility. These characteristics enable
Salmonella
to reshape the immunosuppressive TME, thereby enhancing anti-tumor efficacy. This review elaborates the regulatory effects of
Salmonella
on key components of the TME, the versatile engineering strategies for optimizing
Salmonella
’s ability to modulate the TME, and recent advancements in combination cancer therapies. We also summarize current clinical applications and discuss challenges of developing safer and more effective
Salmonella
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Salmonella
has emerged as a leading candidate with significant therapeutic potential due to its broad-spectrum anti-tumor activity, tumor-targeting ability, immunomodulatory effects, oncolytic properties, genetic programmability, and engineering flexibility. These characteristics enable
Salmonella
to reshape the immunosuppressive TME, thereby enhancing anti-tumor efficacy. This review elaborates the regulatory effects of
Salmonella
on key components of the TME, the versatile engineering strategies for optimizing
Salmonella
’s ability to modulate the TME, and recent advancements in combination cancer therapies. We also summarize current clinical applications and discuss challenges of developing safer and more effective
Salmonella
-based cancer immunotherapy.</description><subject>Animals</subject><subject>Cancer therapies</subject><subject>Genetic engineering</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Immunotherapy - methods</subject><subject>Internal Medicine</subject><subject>Kinases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - therapy</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Review Article</subject><subject>Salmonella - immunology</subject><subject>Tumor Microenvironment - immunology</subject><issn>1559-131X</issn><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1O3DAURi1EBcPAC7CoLHXTTVr_xHaGXYUKVELqokViZznODZNRbKd2Qsvb1yFAURcsLHtxfPxdfwidUvKJEqI-J8oIZwVhZV5CVQXZQysqxKagnN7uvzofoqOUdoQwKtjmAB3yjZSS8WqF_vwwvQse-t4UtUnQ4HEL0QwwjZ3FaYxmhLsO0hnu3BDDfefv8Di5ELHrbAzg77sYvAM_YuMbXMcMzIyH33gbBsBtRq3xFmI2uMmHxf9wjN61pk9w8rSv0c3F15_nV8X198tv51-uC8uEHAtDFSXCMqoEU6UyrSSibCy3sqpU1fCqrSy1RFHbNtaYEmrDLDdMGlpKIQhfo4-LN6f_NUEateuSnef1EKakeeak4IJuMvrhP3QXpuhzupnipVSVkJliC5XHTylCq4fYORMfNCV67kUvvejci37sRc8p3j-pp9pB83LluYgM8AVIw_yFEP-9_Yb2L6_Nmrc</recordid><startdate>20241212</startdate><enddate>20241212</enddate><creator>He, Xiaoe</creator><creator>Guo, Jiayin</creator><creator>Bai, Yanrui</creator><creator>Sun, Hui</creator><creator>Yang, Jing</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1152-5932</orcidid><orcidid>https://orcid.org/0000-0001-5414-2141</orcidid></search><sort><creationdate>20241212</creationdate><title>Salmonella-based therapeutic strategies: improving tumor microenvironment and bringing new hope for cancer immunotherapy</title><author>He, Xiaoe ; Guo, Jiayin ; Bai, Yanrui ; Sun, Hui ; Yang, Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-a17105c21752747af6054dc3c68878d38f8c1c071cfdcaa4eba2c3a26a1465503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Cancer therapies</topic><topic>Genetic engineering</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Immunotherapy - methods</topic><topic>Internal Medicine</topic><topic>Kinases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - therapy</topic><topic>Oncology</topic><topic>Pathology</topic><topic>Review Article</topic><topic>Salmonella - immunology</topic><topic>Tumor Microenvironment - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Xiaoe</creatorcontrib><creatorcontrib>Guo, Jiayin</creatorcontrib><creatorcontrib>Bai, Yanrui</creatorcontrib><creatorcontrib>Sun, Hui</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Xiaoe</au><au>Guo, Jiayin</au><au>Bai, Yanrui</au><au>Sun, Hui</au><au>Yang, Jing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salmonella-based therapeutic strategies: improving tumor microenvironment and bringing new hope for cancer immunotherapy</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2024-12-12</date><risdate>2024</risdate><volume>42</volume><issue>1</issue><spage>27</spage><pages>27-</pages><artnum>27</artnum><issn>1559-131X</issn><issn>1357-0560</issn><eissn>1559-131X</eissn><abstract>Immunotherapy has revolutionized cancer treatment, yet its effectiveness is limited by immunosuppressive tumor microenvironment (TME). To overcome this challenge, innovative strategies to effectively modulate the TME are urgently needed. Over the past decades, bacteria-mediated cancer immunotherapy has recaptured increasing attention, driven by advances in synthetic biology, genetic engineering and our knowledge of host–pathogen interactions. Among various bacterial species,
Salmonella
has emerged as a leading candidate with significant therapeutic potential due to its broad-spectrum anti-tumor activity, tumor-targeting ability, immunomodulatory effects, oncolytic properties, genetic programmability, and engineering flexibility. These characteristics enable
Salmonella
to reshape the immunosuppressive TME, thereby enhancing anti-tumor efficacy. This review elaborates the regulatory effects of
Salmonella
on key components of the TME, the versatile engineering strategies for optimizing
Salmonella
’s ability to modulate the TME, and recent advancements in combination cancer therapies. We also summarize current clinical applications and discuss challenges of developing safer and more effective
Salmonella
-based cancer immunotherapy.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>39666238</pmid><doi>10.1007/s12032-024-02578-0</doi><orcidid>https://orcid.org/0000-0002-1152-5932</orcidid><orcidid>https://orcid.org/0000-0001-5414-2141</orcidid></addata></record> |
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| ispartof | Medical oncology (Northwood, London, England), 2024-12, Vol.42 (1), p.27, Article 27 |
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| subjects | Animals Cancer therapies Genetic engineering Hematology Humans Immunotherapy Immunotherapy - methods Internal Medicine Kinases Medicine Medicine & Public Health Neoplasms - immunology Neoplasms - therapy Oncology Pathology Review Article Salmonella - immunology Tumor Microenvironment - immunology |
| title | Salmonella-based therapeutic strategies: improving tumor microenvironment and bringing new hope for cancer immunotherapy |
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